Nanotechnological approaches to enhance the bioavailability and therapeutic efficacy of green tea polyphenols
Green tea contains numerous bioactive compounds that may provide multiple health benefits, including antioxidative, anti-inflammatory, anti-carcinogenic, anti-proliferative, anti-hypertensive, antithrombogenic and lipid-lowering effects. Most of the chemopreventive and therapeutic effects of green t...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2017-07-01
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| Series: | Journal of Functional Foods |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S1756464617302086 |
| _version_ | 1818406617795788800 |
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| author | Pradeep Puligundla Chulkyoon Mok Sanghoon Ko Jin Liang Neeraja Recharla |
| author_facet | Pradeep Puligundla Chulkyoon Mok Sanghoon Ko Jin Liang Neeraja Recharla |
| author_sort | Pradeep Puligundla |
| collection | DOAJ |
| description | Green tea contains numerous bioactive compounds that may provide multiple health benefits, including antioxidative, anti-inflammatory, anti-carcinogenic, anti-proliferative, anti-hypertensive, antithrombogenic and lipid-lowering effects. Most of the chemopreventive and therapeutic effects of green tea extracts have been attributed to the presence of different polyphenolic bioactives, especially catechins, in their composition. Although these polyphenolic compounds have been shown promising therapeutic effects under in vitro conditions, they met with limited efficacy in clinical settings due to various reasons such as poor oral absorption and bioavailability. Different techniques have been proposed to improve the bioavailability of green tea polyphenols. Among such strategies, nanoparticle-based delivery systems are novel and promising tools. This review is intended to discuss the advances related to improvement of in vitro and in vivo bioavailability of green tea polyphenols using nanotechnological approaches, which in turn would aid in enhancing their therapeutic efficacy. |
| first_indexed | 2024-12-14T09:14:48Z |
| format | Article |
| id | doaj.art-3d8d36dc44bf478a8e0cb3e174cff487 |
| institution | Directory Open Access Journal |
| issn | 1756-4646 |
| language | English |
| last_indexed | 2024-12-14T09:14:48Z |
| publishDate | 2017-07-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Journal of Functional Foods |
| spelling | doaj.art-3d8d36dc44bf478a8e0cb3e174cff4872022-12-21T23:08:28ZengElsevierJournal of Functional Foods1756-46462017-07-0134139151Nanotechnological approaches to enhance the bioavailability and therapeutic efficacy of green tea polyphenolsPradeep Puligundla0Chulkyoon Mok1Sanghoon Ko2Jin Liang3Neeraja Recharla4Department of Food Science & Biotechnology, Gachon University, Seongnam-si, Gyeonggi-do 13120, Republic of Korea; Corresponding author.Department of Food Science & Biotechnology, Gachon University, Seongnam-si, Gyeonggi-do 13120, Republic of KoreaDepartment of Food Science and Technology, Sejong University, 209 Neungdong-ro, Gwangjin-gu, Seoul 05006, Republic of KoreaState Key Laboratory of Tea Plant Biology and Utilization, Anhui Agricultural University, Hefei 230036, PR ChinaDepartment of Food Science and Technology, Sejong University, 209 Neungdong-ro, Gwangjin-gu, Seoul 05006, Republic of KoreaGreen tea contains numerous bioactive compounds that may provide multiple health benefits, including antioxidative, anti-inflammatory, anti-carcinogenic, anti-proliferative, anti-hypertensive, antithrombogenic and lipid-lowering effects. Most of the chemopreventive and therapeutic effects of green tea extracts have been attributed to the presence of different polyphenolic bioactives, especially catechins, in their composition. Although these polyphenolic compounds have been shown promising therapeutic effects under in vitro conditions, they met with limited efficacy in clinical settings due to various reasons such as poor oral absorption and bioavailability. Different techniques have been proposed to improve the bioavailability of green tea polyphenols. Among such strategies, nanoparticle-based delivery systems are novel and promising tools. This review is intended to discuss the advances related to improvement of in vitro and in vivo bioavailability of green tea polyphenols using nanotechnological approaches, which in turn would aid in enhancing their therapeutic efficacy.http://www.sciencedirect.com/science/article/pii/S1756464617302086Green teaPolyphenolsBioavailabilityNanoencapsulationSolid lipid nanoparticleTherapeutic efficacy |
| spellingShingle | Pradeep Puligundla Chulkyoon Mok Sanghoon Ko Jin Liang Neeraja Recharla Nanotechnological approaches to enhance the bioavailability and therapeutic efficacy of green tea polyphenols Journal of Functional Foods Green tea Polyphenols Bioavailability Nanoencapsulation Solid lipid nanoparticle Therapeutic efficacy |
| title | Nanotechnological approaches to enhance the bioavailability and therapeutic efficacy of green tea polyphenols |
| title_full | Nanotechnological approaches to enhance the bioavailability and therapeutic efficacy of green tea polyphenols |
| title_fullStr | Nanotechnological approaches to enhance the bioavailability and therapeutic efficacy of green tea polyphenols |
| title_full_unstemmed | Nanotechnological approaches to enhance the bioavailability and therapeutic efficacy of green tea polyphenols |
| title_short | Nanotechnological approaches to enhance the bioavailability and therapeutic efficacy of green tea polyphenols |
| title_sort | nanotechnological approaches to enhance the bioavailability and therapeutic efficacy of green tea polyphenols |
| topic | Green tea Polyphenols Bioavailability Nanoencapsulation Solid lipid nanoparticle Therapeutic efficacy |
| url | http://www.sciencedirect.com/science/article/pii/S1756464617302086 |
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