Myeloid-Derived Suppressor Cells in Solid Tumors
Myeloid-derived suppressor cells (MDSCs) are one of the main suppressive cell population of the immune system. They play a pivotal role in the establishment of the tumor microenvironment (TME). In the context of cancers or other pathological conditions, MDSCs can differentiate, expand, and migrate i...
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MDPI AG
2022-01-01
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| Series: | Cells |
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| Online Access: | https://www.mdpi.com/2073-4409/11/2/310 |
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| author | Tianmiao Ma Bernhard W. Renz Matthias Ilmer Dominik Koch Yuhui Yang Jens Werner Alexandr V. Bazhin |
| author_facet | Tianmiao Ma Bernhard W. Renz Matthias Ilmer Dominik Koch Yuhui Yang Jens Werner Alexandr V. Bazhin |
| author_sort | Tianmiao Ma |
| collection | DOAJ |
| description | Myeloid-derived suppressor cells (MDSCs) are one of the main suppressive cell population of the immune system. They play a pivotal role in the establishment of the tumor microenvironment (TME). In the context of cancers or other pathological conditions, MDSCs can differentiate, expand, and migrate in large quantities during circulation, inhibiting the cytotoxic functions of T cells and NK cells. This process is regulated by ROS, iNOS/NO, arginase-1, and multiple soluble cytokines. The definition of MDSCs and their phenotypes in humans are not as well represented as in other organisms such as mice, owing to the absence of the cognate molecule. However, a comprehensive understanding of the differences between different species and subsets will be beneficial for clarifying the immunosuppressive properties and potential clinical values of these cells during tumor progression. Recently, experimental evidence and clinical investigations have demonstrated that MDSCs have a close relationship with poor prognosis and drug resistance, which is considered to be a leading marker for practical applications and therapeutic methods. In this review, we summarize the remarkable position of MDSCs in solid tumors, explain their classifications in different models, and introduce new treatment approaches to target MDSCs to better understand the advancement of new approaches to cancer treatment. |
| first_indexed | 2024-03-10T01:43:08Z |
| format | Article |
| id | doaj.art-3d90cd97d3c84a80abdd1dc9fbfe3a52 |
| institution | Directory Open Access Journal |
| issn | 2073-4409 |
| language | English |
| last_indexed | 2024-03-10T01:43:08Z |
| publishDate | 2022-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cells |
| spelling | doaj.art-3d90cd97d3c84a80abdd1dc9fbfe3a522023-11-23T13:19:35ZengMDPI AGCells2073-44092022-01-0111231010.3390/cells11020310Myeloid-Derived Suppressor Cells in Solid TumorsTianmiao Ma0Bernhard W. Renz1Matthias Ilmer2Dominik Koch3Yuhui Yang4Jens Werner5Alexandr V. Bazhin6Department of General, Visceral and Transplant Surgery, Ludwig-Maximilians-University Munich, 81377 Munich, GermanyDepartment of General, Visceral and Transplant Surgery, Ludwig-Maximilians-University Munich, 81377 Munich, GermanyDepartment of General, Visceral and Transplant Surgery, Ludwig-Maximilians-University Munich, 81377 Munich, GermanyDepartment of General, Visceral and Transplant Surgery, Ludwig-Maximilians-University Munich, 81377 Munich, GermanyCancer Center, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, 1277 Jiefang Avenue, Wuhan 430022, ChinaDepartment of General, Visceral and Transplant Surgery, Ludwig-Maximilians-University Munich, 81377 Munich, GermanyDepartment of General, Visceral and Transplant Surgery, Ludwig-Maximilians-University Munich, 81377 Munich, GermanyMyeloid-derived suppressor cells (MDSCs) are one of the main suppressive cell population of the immune system. They play a pivotal role in the establishment of the tumor microenvironment (TME). In the context of cancers or other pathological conditions, MDSCs can differentiate, expand, and migrate in large quantities during circulation, inhibiting the cytotoxic functions of T cells and NK cells. This process is regulated by ROS, iNOS/NO, arginase-1, and multiple soluble cytokines. The definition of MDSCs and their phenotypes in humans are not as well represented as in other organisms such as mice, owing to the absence of the cognate molecule. However, a comprehensive understanding of the differences between different species and subsets will be beneficial for clarifying the immunosuppressive properties and potential clinical values of these cells during tumor progression. Recently, experimental evidence and clinical investigations have demonstrated that MDSCs have a close relationship with poor prognosis and drug resistance, which is considered to be a leading marker for practical applications and therapeutic methods. In this review, we summarize the remarkable position of MDSCs in solid tumors, explain their classifications in different models, and introduce new treatment approaches to target MDSCs to better understand the advancement of new approaches to cancer treatment.https://www.mdpi.com/2073-4409/11/2/310myeloid-derived suppressor cells (MDSCs)solid tumorimmunotherapytumor microenvironment (TME) |
| spellingShingle | Tianmiao Ma Bernhard W. Renz Matthias Ilmer Dominik Koch Yuhui Yang Jens Werner Alexandr V. Bazhin Myeloid-Derived Suppressor Cells in Solid Tumors Cells myeloid-derived suppressor cells (MDSCs) solid tumor immunotherapy tumor microenvironment (TME) |
| title | Myeloid-Derived Suppressor Cells in Solid Tumors |
| title_full | Myeloid-Derived Suppressor Cells in Solid Tumors |
| title_fullStr | Myeloid-Derived Suppressor Cells in Solid Tumors |
| title_full_unstemmed | Myeloid-Derived Suppressor Cells in Solid Tumors |
| title_short | Myeloid-Derived Suppressor Cells in Solid Tumors |
| title_sort | myeloid derived suppressor cells in solid tumors |
| topic | myeloid-derived suppressor cells (MDSCs) solid tumor immunotherapy tumor microenvironment (TME) |
| url | https://www.mdpi.com/2073-4409/11/2/310 |
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