Toll-like receptor 5 and Toll-like receptor 9 single nucleotide polymorphisms and risk of systemic lupus erythematosus and nephritis in Egyptian patients
Abstract Background Toll-like (TLRs) play a crucial role in both adaptive and innate immunity. The aim of the present study was to assess the association of TLR5-rs5744168, TLR9-rs187084, and TLR9-rs352140 single nucleotide polymorphisms (SNPs) with susceptibility to systemic lupus erythematosus (SL...
| Main Authors: | , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
SpringerOpen
2021-12-01
|
| Series: | Egyptian Rheumatology and Rehabilitation |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s43166-021-00093-y |
| _version_ | 1818701404420702208 |
|---|---|
| author | Ola Mohammad Gharbia Sherine Abdel Rahman Bassiouni Maysaa El Sayed Zaki Shimaa Mohsen El-Beah Manal Mohamed El-Desoky Eman Adel Elmansoury Mostafa Abdelsalam |
| author_facet | Ola Mohammad Gharbia Sherine Abdel Rahman Bassiouni Maysaa El Sayed Zaki Shimaa Mohsen El-Beah Manal Mohamed El-Desoky Eman Adel Elmansoury Mostafa Abdelsalam |
| author_sort | Ola Mohammad Gharbia |
| collection | DOAJ |
| description | Abstract Background Toll-like (TLRs) play a crucial role in both adaptive and innate immunity. The aim of the present study was to assess the association of TLR5-rs5744168, TLR9-rs187084, and TLR9-rs352140 single nucleotide polymorphisms (SNPs) with susceptibility to systemic lupus erythematosus (SLE) and lupus nephritis (LN) in Egyptian patients. Results The C allele and homozygous CC genotype of the TLR9-rs352140 in co-dominant and recessive models were more prevalent in SLE patients than controls (P = 0.047, P = 0.017, and P = 0.005 respectively). In contrast, allelic and genotyping distribution of TLR5-rs5744168 and TLR9-rs187084 SNPs showed no association with the risk of SLE. The T allele of the TLR5-rs5744168 was more prevalent in LN patients than controls (P = 0.021). The homozygous TT genotype of TLR5-rs5744168 SNP was more prevalent in LN patients in the co-dominant and the recessive models than controls (P = 0.036 and P = 0.011 respectively). The C allele of the TLR9-rs352140 was more prevalent in LN patients than controls (P = 0.015). The homozygous CC genotype of the TLR9-rs352140 SNP was more prevalent in LN than controls in co-dominant and recessive models (P = 0.002 and P < 0.001). In the recessive model of the TLR5-rs5744168 SNP, the TT genotype was found in 3.2% of the SLE patients while none of the SLE patients without LN or controls had TT genotype (P = 0.036). Also, in the recessive model of the TLR9-rs352140 SNP, the CC genotype was significantly more frequent in SLE patients with LN than without LN (44.4% vs 29.9%, P = 0.045). Conclusion Our results support the potential role of TLR5-rs5744168 SNP and TLR9-rs3532140 SNP not only in increasing the risk for development of SLE, but also in increasing the risk of LN in SLE patients among the Egyptian population. |
| first_indexed | 2024-12-17T15:20:18Z |
| format | Article |
| id | doaj.art-3d9114f05c3d4209a4fab8df09a87347 |
| institution | Directory Open Access Journal |
| issn | 1110-161X 2090-3235 |
| language | English |
| last_indexed | 2024-12-17T15:20:18Z |
| publishDate | 2021-12-01 |
| publisher | SpringerOpen |
| record_format | Article |
| series | Egyptian Rheumatology and Rehabilitation |
| spelling | doaj.art-3d9114f05c3d4209a4fab8df09a873472022-12-21T21:43:24ZengSpringerOpenEgyptian Rheumatology and Rehabilitation1110-161X2090-32352021-12-0148111010.1186/s43166-021-00093-yToll-like receptor 5 and Toll-like receptor 9 single nucleotide polymorphisms and risk of systemic lupus erythematosus and nephritis in Egyptian patientsOla Mohammad Gharbia0Sherine Abdel Rahman Bassiouni1Maysaa El Sayed Zaki2Shimaa Mohsen El-Beah3Manal Mohamed El-Desoky4Eman Adel Elmansoury5Mostafa Abdelsalam6Physical Medicine, Rheumatology and Rehabilitation Department, Faculty of Medicine, Mansoura UniversityPhysical Medicine, Rheumatology and Rehabilitation Department, Faculty of Medicine, Mansoura UniversityClinical Pathology Department, Faculty of Medicine, Mansoura UniversityMedical Biochemistry and Molecular Biology Department, Faculty of Medicine, Mansoura UniversityMedical Biochemistry and Molecular Biology Department, Faculty of Medicine, Mansoura UniversityMedical Microbiology and Immunology Department, Faculty of Medicine, Mansoura UniversityMansoura Nephrology and Dialysis Unit, Internal Medicine Department, Faculty of Medicine, Mansoura UniversityAbstract Background Toll-like (TLRs) play a crucial role in both adaptive and innate immunity. The aim of the present study was to assess the association of TLR5-rs5744168, TLR9-rs187084, and TLR9-rs352140 single nucleotide polymorphisms (SNPs) with susceptibility to systemic lupus erythematosus (SLE) and lupus nephritis (LN) in Egyptian patients. Results The C allele and homozygous CC genotype of the TLR9-rs352140 in co-dominant and recessive models were more prevalent in SLE patients than controls (P = 0.047, P = 0.017, and P = 0.005 respectively). In contrast, allelic and genotyping distribution of TLR5-rs5744168 and TLR9-rs187084 SNPs showed no association with the risk of SLE. The T allele of the TLR5-rs5744168 was more prevalent in LN patients than controls (P = 0.021). The homozygous TT genotype of TLR5-rs5744168 SNP was more prevalent in LN patients in the co-dominant and the recessive models than controls (P = 0.036 and P = 0.011 respectively). The C allele of the TLR9-rs352140 was more prevalent in LN patients than controls (P = 0.015). The homozygous CC genotype of the TLR9-rs352140 SNP was more prevalent in LN than controls in co-dominant and recessive models (P = 0.002 and P < 0.001). In the recessive model of the TLR5-rs5744168 SNP, the TT genotype was found in 3.2% of the SLE patients while none of the SLE patients without LN or controls had TT genotype (P = 0.036). Also, in the recessive model of the TLR9-rs352140 SNP, the CC genotype was significantly more frequent in SLE patients with LN than without LN (44.4% vs 29.9%, P = 0.045). Conclusion Our results support the potential role of TLR5-rs5744168 SNP and TLR9-rs3532140 SNP not only in increasing the risk for development of SLE, but also in increasing the risk of LN in SLE patients among the Egyptian population.https://doi.org/10.1186/s43166-021-00093-yToll-like receptorSystemic lupus erythematosusLupus nephritisSingle nucleotide polymorphisms |
| spellingShingle | Ola Mohammad Gharbia Sherine Abdel Rahman Bassiouni Maysaa El Sayed Zaki Shimaa Mohsen El-Beah Manal Mohamed El-Desoky Eman Adel Elmansoury Mostafa Abdelsalam Toll-like receptor 5 and Toll-like receptor 9 single nucleotide polymorphisms and risk of systemic lupus erythematosus and nephritis in Egyptian patients Egyptian Rheumatology and Rehabilitation Toll-like receptor Systemic lupus erythematosus Lupus nephritis Single nucleotide polymorphisms |
| title | Toll-like receptor 5 and Toll-like receptor 9 single nucleotide polymorphisms and risk of systemic lupus erythematosus and nephritis in Egyptian patients |
| title_full | Toll-like receptor 5 and Toll-like receptor 9 single nucleotide polymorphisms and risk of systemic lupus erythematosus and nephritis in Egyptian patients |
| title_fullStr | Toll-like receptor 5 and Toll-like receptor 9 single nucleotide polymorphisms and risk of systemic lupus erythematosus and nephritis in Egyptian patients |
| title_full_unstemmed | Toll-like receptor 5 and Toll-like receptor 9 single nucleotide polymorphisms and risk of systemic lupus erythematosus and nephritis in Egyptian patients |
| title_short | Toll-like receptor 5 and Toll-like receptor 9 single nucleotide polymorphisms and risk of systemic lupus erythematosus and nephritis in Egyptian patients |
| title_sort | toll like receptor 5 and toll like receptor 9 single nucleotide polymorphisms and risk of systemic lupus erythematosus and nephritis in egyptian patients |
| topic | Toll-like receptor Systemic lupus erythematosus Lupus nephritis Single nucleotide polymorphisms |
| url | https://doi.org/10.1186/s43166-021-00093-y |
| work_keys_str_mv | AT olamohammadgharbia tolllikereceptor5andtolllikereceptor9singlenucleotidepolymorphismsandriskofsystemiclupuserythematosusandnephritisinegyptianpatients AT sherineabdelrahmanbassiouni tolllikereceptor5andtolllikereceptor9singlenucleotidepolymorphismsandriskofsystemiclupuserythematosusandnephritisinegyptianpatients AT maysaaelsayedzaki tolllikereceptor5andtolllikereceptor9singlenucleotidepolymorphismsandriskofsystemiclupuserythematosusandnephritisinegyptianpatients AT shimaamohsenelbeah tolllikereceptor5andtolllikereceptor9singlenucleotidepolymorphismsandriskofsystemiclupuserythematosusandnephritisinegyptianpatients AT manalmohamedeldesoky tolllikereceptor5andtolllikereceptor9singlenucleotidepolymorphismsandriskofsystemiclupuserythematosusandnephritisinegyptianpatients AT emanadelelmansoury tolllikereceptor5andtolllikereceptor9singlenucleotidepolymorphismsandriskofsystemiclupuserythematosusandnephritisinegyptianpatients AT mostafaabdelsalam tolllikereceptor5andtolllikereceptor9singlenucleotidepolymorphismsandriskofsystemiclupuserythematosusandnephritisinegyptianpatients |