Macular Telangiectasia Type 2: A Comprehensive Review
Kiran Chandra Kedarisetti,1 Raja Narayanan,1,2 Michael W Stewart,3 Nikitha Reddy Gurram,1 Arshad M Khanani4,5 1Anant Bajaj Retina Institute, LV Prasad Eye Institute, Hyderabad, Telangana, India; 2Indian Health Outcomes, Public Health and Economics Research Centre (IHOPE), Hyderabad, Telangana, India...
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| Format: | Article |
| Language: | English |
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Dove Medical Press
2022-10-01
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| Series: | Clinical Ophthalmology |
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| Online Access: | https://www.dovepress.com/macular-telangiectasia-type-2-a-comprehensive-review-peer-reviewed-fulltext-article-OPTH |
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| author | Kedarisetti KC Narayanan R Stewart MW Reddy Gurram N Khanani AM |
| author_facet | Kedarisetti KC Narayanan R Stewart MW Reddy Gurram N Khanani AM |
| author_sort | Kedarisetti KC |
| collection | DOAJ |
| description | Kiran Chandra Kedarisetti,1 Raja Narayanan,1,2 Michael W Stewart,3 Nikitha Reddy Gurram,1 Arshad M Khanani4,5 1Anant Bajaj Retina Institute, LV Prasad Eye Institute, Hyderabad, Telangana, India; 2Indian Health Outcomes, Public Health and Economics Research Centre (IHOPE), Hyderabad, Telangana, India; 3Department of Ophthalmology, Mayo Clinic, Jacksonville, FL, USA; 4Department of Clinical research, Sierra Eye Associates, Reno, NV, USA; 5Department of Ophthalmology, The University of Nevada, Reno, NV, USACorrespondence: Raja Narayanan, Anant Bajaj Retina Institute, L V Prasad Eye Institute, Hyderabad, Telangana, India, Tel +91-9177111975, Email narayanan@lvpei.orgAbstract: Macular telangiectasia Type 2 (MacTel) is a gradually progressive disease that affects the quality of life by impairing both distant and near vision. It had previously been considered a vascular condition, but recent evidence suggests a neurodegenerative etiology, with primary involvement of Muller cells. Retinal pigment epithelium (RPE) hyperplasia and subretinal neovascularization (SNV) are responsible for most of the vision loss in advanced cases. Neurotrophic factors in the non-proliferative phase and intravitreal anti-Vascular Endothelial growth factor (VEGF) in the proliferative phase have shown to retard the progression of the disease. This review will discuss the pathophysiology, clinical features, important diagnostic imaging studies and available treatment options for MacTel.Keywords: macular telangiectasia type 2, MacTel, CNTF, ciliary neurotrophic factor |
| first_indexed | 2024-04-14T00:07:33Z |
| format | Article |
| id | doaj.art-3d91fe1c07884ecabc55ebceefcebb94 |
| institution | Directory Open Access Journal |
| issn | 1177-5483 |
| language | English |
| last_indexed | 2024-04-14T00:07:33Z |
| publishDate | 2022-10-01 |
| publisher | Dove Medical Press |
| record_format | Article |
| series | Clinical Ophthalmology |
| spelling | doaj.art-3d91fe1c07884ecabc55ebceefcebb942022-12-22T02:23:28ZengDove Medical PressClinical Ophthalmology1177-54832022-10-01Volume 163297330978809Macular Telangiectasia Type 2: A Comprehensive ReviewKedarisetti KCNarayanan RStewart MWReddy Gurram NKhanani AMKiran Chandra Kedarisetti,1 Raja Narayanan,1,2 Michael W Stewart,3 Nikitha Reddy Gurram,1 Arshad M Khanani4,5 1Anant Bajaj Retina Institute, LV Prasad Eye Institute, Hyderabad, Telangana, India; 2Indian Health Outcomes, Public Health and Economics Research Centre (IHOPE), Hyderabad, Telangana, India; 3Department of Ophthalmology, Mayo Clinic, Jacksonville, FL, USA; 4Department of Clinical research, Sierra Eye Associates, Reno, NV, USA; 5Department of Ophthalmology, The University of Nevada, Reno, NV, USACorrespondence: Raja Narayanan, Anant Bajaj Retina Institute, L V Prasad Eye Institute, Hyderabad, Telangana, India, Tel +91-9177111975, Email narayanan@lvpei.orgAbstract: Macular telangiectasia Type 2 (MacTel) is a gradually progressive disease that affects the quality of life by impairing both distant and near vision. It had previously been considered a vascular condition, but recent evidence suggests a neurodegenerative etiology, with primary involvement of Muller cells. Retinal pigment epithelium (RPE) hyperplasia and subretinal neovascularization (SNV) are responsible for most of the vision loss in advanced cases. Neurotrophic factors in the non-proliferative phase and intravitreal anti-Vascular Endothelial growth factor (VEGF) in the proliferative phase have shown to retard the progression of the disease. This review will discuss the pathophysiology, clinical features, important diagnostic imaging studies and available treatment options for MacTel.Keywords: macular telangiectasia type 2, MacTel, CNTF, ciliary neurotrophic factorhttps://www.dovepress.com/macular-telangiectasia-type-2-a-comprehensive-review-peer-reviewed-fulltext-article-OPTHmacular telangiectasia type 2mactelcntfciliary neurotrophic factorreview article |
| spellingShingle | Kedarisetti KC Narayanan R Stewart MW Reddy Gurram N Khanani AM Macular Telangiectasia Type 2: A Comprehensive Review Clinical Ophthalmology macular telangiectasia type 2 mactel cntf ciliary neurotrophic factor review article |
| title | Macular Telangiectasia Type 2: A Comprehensive Review |
| title_full | Macular Telangiectasia Type 2: A Comprehensive Review |
| title_fullStr | Macular Telangiectasia Type 2: A Comprehensive Review |
| title_full_unstemmed | Macular Telangiectasia Type 2: A Comprehensive Review |
| title_short | Macular Telangiectasia Type 2: A Comprehensive Review |
| title_sort | macular telangiectasia type 2 a comprehensive review |
| topic | macular telangiectasia type 2 mactel cntf ciliary neurotrophic factor review article |
| url | https://www.dovepress.com/macular-telangiectasia-type-2-a-comprehensive-review-peer-reviewed-fulltext-article-OPTH |
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