Primary membranous nephropathy in two siblings with one combined with anti-glomerular basement membrane disease: a case report
Abstract Background The phospholipase A2 receptor (PLA2R) associated with membranous nephropathy (MN) is an organ-specific autoimmune disease associated with PLA2R and human leukocyte antigen (HLA) genes. Familial PLA2R-related MN is rarely reported. The combination of anti-GBM disease and MN has be...
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| Format: | Article |
| Language: | English |
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BMC
2023-06-01
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| Series: | BMC Nephrology |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s12882-023-03132-2 |
| _version_ | 1797795769633210368 |
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| author | Yan-jiao Cheng Xiao-yu Jia Hong-ru Cao Xiao-yi Zhao Xu-jie Zhou Xiao-juan Yu Rong Xu Fu-de Zhou Su-xia Wang Zhao Cui Ming-hui Zhao |
| author_facet | Yan-jiao Cheng Xiao-yu Jia Hong-ru Cao Xiao-yi Zhao Xu-jie Zhou Xiao-juan Yu Rong Xu Fu-de Zhou Su-xia Wang Zhao Cui Ming-hui Zhao |
| author_sort | Yan-jiao Cheng |
| collection | DOAJ |
| description | Abstract Background The phospholipase A2 receptor (PLA2R) associated with membranous nephropathy (MN) is an organ-specific autoimmune disease associated with PLA2R and human leukocyte antigen (HLA) genes. Familial PLA2R-related MN is rarely reported. The combination of anti-GBM disease and MN has been well documented, though the mechanism behind it remains unclear. Case presentation We describe two siblings diagnosed with pathology-confirmed PLA2R-related MN 1 year apart. And one of the two siblings developed an anti-GBM disease. The high-resolution HLA typing showed identical alleles in both siblings, specifically heterozygotes of DRB1*15:01/*03:01. Conclusion We describe a familial case of PLA2R-related MN supporting the role of genetic factors that HLA-DRB1*15:01 and DRB1*03:01 predispose patients in the development of PLA2R-related MN in the Han Chinese population. The combination of MN and anti-GBM disease may also partially be associated with the same susceptible HLA allele DRB1*15:01. |
| first_indexed | 2024-03-13T03:23:01Z |
| format | Article |
| id | doaj.art-3d9324bf78c9475988e8509ca9f1b9de |
| institution | Directory Open Access Journal |
| issn | 1471-2369 |
| language | English |
| last_indexed | 2024-03-13T03:23:01Z |
| publishDate | 2023-06-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Nephrology |
| spelling | doaj.art-3d9324bf78c9475988e8509ca9f1b9de2023-06-25T11:11:22ZengBMCBMC Nephrology1471-23692023-06-012411510.1186/s12882-023-03132-2Primary membranous nephropathy in two siblings with one combined with anti-glomerular basement membrane disease: a case reportYan-jiao Cheng0Xiao-yu Jia1Hong-ru Cao2Xiao-yi Zhao3Xu-jie Zhou4Xiao-juan Yu5Rong Xu6Fu-de Zhou7Su-xia Wang8Zhao Cui9Ming-hui Zhao10Renal Division, Peking University First HospitalRenal Division, Peking University First HospitalRenal Division, Affiliated Hospital of Chifeng UniversityRenal Division, Affiliated Hospital of Chifeng UniversityRenal Division, Peking University First HospitalRenal Division, Peking University First HospitalRenal Division, Peking University First HospitalRenal Division, Peking University First HospitalRenal Division, Peking University First HospitalRenal Division, Peking University First HospitalRenal Division, Peking University First HospitalAbstract Background The phospholipase A2 receptor (PLA2R) associated with membranous nephropathy (MN) is an organ-specific autoimmune disease associated with PLA2R and human leukocyte antigen (HLA) genes. Familial PLA2R-related MN is rarely reported. The combination of anti-GBM disease and MN has been well documented, though the mechanism behind it remains unclear. Case presentation We describe two siblings diagnosed with pathology-confirmed PLA2R-related MN 1 year apart. And one of the two siblings developed an anti-GBM disease. The high-resolution HLA typing showed identical alleles in both siblings, specifically heterozygotes of DRB1*15:01/*03:01. Conclusion We describe a familial case of PLA2R-related MN supporting the role of genetic factors that HLA-DRB1*15:01 and DRB1*03:01 predispose patients in the development of PLA2R-related MN in the Han Chinese population. The combination of MN and anti-GBM disease may also partially be associated with the same susceptible HLA allele DRB1*15:01.https://doi.org/10.1186/s12882-023-03132-2Primary membranous nephropathyAnti-PLA2R antibodyHLAAnti-glomerular basement membrane diseaseCase report |
| spellingShingle | Yan-jiao Cheng Xiao-yu Jia Hong-ru Cao Xiao-yi Zhao Xu-jie Zhou Xiao-juan Yu Rong Xu Fu-de Zhou Su-xia Wang Zhao Cui Ming-hui Zhao Primary membranous nephropathy in two siblings with one combined with anti-glomerular basement membrane disease: a case report BMC Nephrology Primary membranous nephropathy Anti-PLA2R antibody HLA Anti-glomerular basement membrane disease Case report |
| title | Primary membranous nephropathy in two siblings with one combined with anti-glomerular basement membrane disease: a case report |
| title_full | Primary membranous nephropathy in two siblings with one combined with anti-glomerular basement membrane disease: a case report |
| title_fullStr | Primary membranous nephropathy in two siblings with one combined with anti-glomerular basement membrane disease: a case report |
| title_full_unstemmed | Primary membranous nephropathy in two siblings with one combined with anti-glomerular basement membrane disease: a case report |
| title_short | Primary membranous nephropathy in two siblings with one combined with anti-glomerular basement membrane disease: a case report |
| title_sort | primary membranous nephropathy in two siblings with one combined with anti glomerular basement membrane disease a case report |
| topic | Primary membranous nephropathy Anti-PLA2R antibody HLA Anti-glomerular basement membrane disease Case report |
| url | https://doi.org/10.1186/s12882-023-03132-2 |
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