Effect of Thymus migricus Extract Supplementation on the Metabolic, Hematologic and Oxidative Indices in Type 2 Diabetic Rats
Background & objectives: Type 2 diabetes mellitus is characterized by metabolic disorders and elevated blood glucose. It is one of the most common diseases in developed countries. Thyme is one of the herbs which have been used in some drug content due to its high antioxidant properties. Thyme ca...
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| Format: | Article |
| Language: | fas |
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Ardabil University of Medical Sciences
2019-09-01
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| Series: | Journal of Ardabil University of Medical Sciences |
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| Online Access: | http://jarums.arums.ac.ir/article-1-1674-en.html |
| _version_ | 1811293163702190080 |
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| author | Mahdi faramoushi Ramin Amirsasan Vahid Sarri Sarraf |
| author_facet | Mahdi faramoushi Ramin Amirsasan Vahid Sarri Sarraf |
| author_sort | Mahdi faramoushi |
| collection | DOAJ |
| description | Background & objectives: Type 2 diabetes mellitus is characterized by metabolic disorders and elevated blood glucose. It is one of the most common diseases in developed countries. Thyme is one of the herbs which have been used in some drug content due to its high antioxidant properties. Thyme can increase the activity of mitochondrial oxidative enzymes and affect metabolic and hematological indices due to its phenolic compounds.
So, the aim of this study was to determine the effect of Thymus migricus extract supplementation on the metabolic, hematological indices and oxidative stress in type 2 diabetic rats.
Methods: For this purpose, 24 Wistar rats (220-240g) were divided randomly into three groups; group1: healthy control group (NC, n=8), group2: diabetic control group (D, n=8) that took fat diet for 2 weeks then were injected with streptozotocin (37 mg/kg), and group3: diabetic+Thyme group (Th+D,n=8). Thyme hydro-alcoholic extract dissolved in distilled water to the desired concentration (400 mg/kg) according to their daily water consumption (30 ml). Then glycemic, blood and lipid indices were measured in the peripheral blood of the rats.
Results: The results revealed that thyme supplementation significantly decreased the fasting blood glucose level (356.35±40 mg/dl to 261.61±35 mg/dl) and HOMA-IR index (3.52±0.30 mg/dl to 2.2±0.33 mg/dl). Also significantly decreased the lipid profile level of the Th+D group compared to those of the D group (p<0.05), but the hematological parameters of the Th+D group compared to those of D group were not significantly changed. FRAP in Th+D group was not significantly different in comparison with the other two groups, but MDA was significantly increased in diabetic groups (p<0.05).
Conclusion: Based on the results, thyme supplementation by decreasing insulin resistance and fasting blood glucose can improve lipid parameters, but does not affect blood parameters and antioxidant indices. |
| first_indexed | 2024-04-13T04:56:58Z |
| format | Article |
| id | doaj.art-3d941c94a24542fe9aec72ab1ebd31ff |
| institution | Directory Open Access Journal |
| issn | 2228-7280 2228-7299 |
| language | fas |
| last_indexed | 2024-04-13T04:56:58Z |
| publishDate | 2019-09-01 |
| publisher | Ardabil University of Medical Sciences |
| record_format | Article |
| series | Journal of Ardabil University of Medical Sciences |
| spelling | doaj.art-3d941c94a24542fe9aec72ab1ebd31ff2022-12-22T03:01:27ZfasArdabil University of Medical SciencesJournal of Ardabil University of Medical Sciences2228-72802228-72992019-09-01192191203Effect of Thymus migricus Extract Supplementation on the Metabolic, Hematologic and Oxidative Indices in Type 2 Diabetic RatsMahdi faramoushi0Ramin Amirsasan1Vahid Sarri Sarraf2 Faculty of Multimedia, Tabriz Islamic Art University, Tabriz, Iran Department of Sport Physiology, Faculty of Physical Education and Sport Sciences, University of Tabriz, Tabriz, Iran Department of Sport Physiology, Faculty of Physical Education and Sport Sciences, University of Tabriz, Tabriz, Iran Background & objectives: Type 2 diabetes mellitus is characterized by metabolic disorders and elevated blood glucose. It is one of the most common diseases in developed countries. Thyme is one of the herbs which have been used in some drug content due to its high antioxidant properties. Thyme can increase the activity of mitochondrial oxidative enzymes and affect metabolic and hematological indices due to its phenolic compounds. So, the aim of this study was to determine the effect of Thymus migricus extract supplementation on the metabolic, hematological indices and oxidative stress in type 2 diabetic rats. Methods: For this purpose, 24 Wistar rats (220-240g) were divided randomly into three groups; group1: healthy control group (NC, n=8), group2: diabetic control group (D, n=8) that took fat diet for 2 weeks then were injected with streptozotocin (37 mg/kg), and group3: diabetic+Thyme group (Th+D,n=8). Thyme hydro-alcoholic extract dissolved in distilled water to the desired concentration (400 mg/kg) according to their daily water consumption (30 ml). Then glycemic, blood and lipid indices were measured in the peripheral blood of the rats. Results: The results revealed that thyme supplementation significantly decreased the fasting blood glucose level (356.35±40 mg/dl to 261.61±35 mg/dl) and HOMA-IR index (3.52±0.30 mg/dl to 2.2±0.33 mg/dl). Also significantly decreased the lipid profile level of the Th+D group compared to those of the D group (p<0.05), but the hematological parameters of the Th+D group compared to those of D group were not significantly changed. FRAP in Th+D group was not significantly different in comparison with the other two groups, but MDA was significantly increased in diabetic groups (p<0.05). Conclusion: Based on the results, thyme supplementation by decreasing insulin resistance and fasting blood glucose can improve lipid parameters, but does not affect blood parameters and antioxidant indices.http://jarums.arums.ac.ir/article-1-1674-en.htmlthymus migricus supplementationmetabolic indexhematologicrattype 2 diabetes |
| spellingShingle | Mahdi faramoushi Ramin Amirsasan Vahid Sarri Sarraf Effect of Thymus migricus Extract Supplementation on the Metabolic, Hematologic and Oxidative Indices in Type 2 Diabetic Rats Journal of Ardabil University of Medical Sciences thymus migricus supplementation metabolic index hematologic rat type 2 diabetes |
| title | Effect of Thymus migricus Extract Supplementation on the Metabolic, Hematologic and Oxidative Indices in Type 2 Diabetic Rats |
| title_full | Effect of Thymus migricus Extract Supplementation on the Metabolic, Hematologic and Oxidative Indices in Type 2 Diabetic Rats |
| title_fullStr | Effect of Thymus migricus Extract Supplementation on the Metabolic, Hematologic and Oxidative Indices in Type 2 Diabetic Rats |
| title_full_unstemmed | Effect of Thymus migricus Extract Supplementation on the Metabolic, Hematologic and Oxidative Indices in Type 2 Diabetic Rats |
| title_short | Effect of Thymus migricus Extract Supplementation on the Metabolic, Hematologic and Oxidative Indices in Type 2 Diabetic Rats |
| title_sort | effect of thymus migricus extract supplementation on the metabolic hematologic and oxidative indices in type 2 diabetic rats |
| topic | thymus migricus supplementation metabolic index hematologic rat type 2 diabetes |
| url | http://jarums.arums.ac.ir/article-1-1674-en.html |
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