Calcium Signaling Is Required for Erythroid Enucleation.
Although erythroid enucleation, the property of erythroblasts to expel their nucleus, has been known for 7ore than a century, surprisingly little is known regarding the molecular mechanisms governing this unique developmental process. Here we show that similar to cytokinesis, nuclear extrusion requi...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Public Library of Science (PLoS)
2016-01-01
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| Series: | PLoS ONE |
| Online Access: | http://europepmc.org/articles/PMC4701494?pdf=render |
| _version_ | 1819021291197300736 |
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| author | Christina B Wölwer Luke B Pase Sarah M Russell Patrick O Humbert |
| author_facet | Christina B Wölwer Luke B Pase Sarah M Russell Patrick O Humbert |
| author_sort | Christina B Wölwer |
| collection | DOAJ |
| description | Although erythroid enucleation, the property of erythroblasts to expel their nucleus, has been known for 7ore than a century, surprisingly little is known regarding the molecular mechanisms governing this unique developmental process. Here we show that similar to cytokinesis, nuclear extrusion requires intracellular calcium signaling and signal transduction through the calmodulin (CaM) pathway. However, in contrast to cytokinesis we found that orthochromatic erythroblasts require uptake of extracellular calcium to enucleate. Together these functional studies highlight a critical role for calcium signaling in the regulation of erythroid enucleation. |
| first_indexed | 2024-12-21T04:04:46Z |
| format | Article |
| id | doaj.art-3d9578e7d6d54703a1bf6917ce307509 |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-12-21T04:04:46Z |
| publishDate | 2016-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj.art-3d9578e7d6d54703a1bf6917ce3075092022-12-21T19:16:37ZengPublic Library of Science (PLoS)PLoS ONE1932-62032016-01-01111e014620110.1371/journal.pone.0146201Calcium Signaling Is Required for Erythroid Enucleation.Christina B WölwerLuke B PaseSarah M RussellPatrick O HumbertAlthough erythroid enucleation, the property of erythroblasts to expel their nucleus, has been known for 7ore than a century, surprisingly little is known regarding the molecular mechanisms governing this unique developmental process. Here we show that similar to cytokinesis, nuclear extrusion requires intracellular calcium signaling and signal transduction through the calmodulin (CaM) pathway. However, in contrast to cytokinesis we found that orthochromatic erythroblasts require uptake of extracellular calcium to enucleate. Together these functional studies highlight a critical role for calcium signaling in the regulation of erythroid enucleation.http://europepmc.org/articles/PMC4701494?pdf=render |
| spellingShingle | Christina B Wölwer Luke B Pase Sarah M Russell Patrick O Humbert Calcium Signaling Is Required for Erythroid Enucleation. PLoS ONE |
| title | Calcium Signaling Is Required for Erythroid Enucleation. |
| title_full | Calcium Signaling Is Required for Erythroid Enucleation. |
| title_fullStr | Calcium Signaling Is Required for Erythroid Enucleation. |
| title_full_unstemmed | Calcium Signaling Is Required for Erythroid Enucleation. |
| title_short | Calcium Signaling Is Required for Erythroid Enucleation. |
| title_sort | calcium signaling is required for erythroid enucleation |
| url | http://europepmc.org/articles/PMC4701494?pdf=render |
| work_keys_str_mv | AT christinabwolwer calciumsignalingisrequiredforerythroidenucleation AT lukebpase calciumsignalingisrequiredforerythroidenucleation AT sarahmrussell calciumsignalingisrequiredforerythroidenucleation AT patrickohumbert calciumsignalingisrequiredforerythroidenucleation |