Mechanisms of Membrane Curvature Generation in Membrane Traffic
During the vesicular trafficking process, cellular membranes undergo dynamic morphological changes, in particular at the vesicle generation and fusion steps. Changes in membrane shape are regulated by small GTPases, coat proteins and other accessory proteins, such as BAR domain-containing proteins....
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2012-02-01
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| Series: | Membranes |
| Subjects: | |
| Online Access: | http://www.mdpi.com/2077-0375/2/1/118/ |
| _version_ | 1827843348051787776 |
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| author | Hye-Won Shin Kazuhisa Nakayama Hiroyuki Takatsu |
| author_facet | Hye-Won Shin Kazuhisa Nakayama Hiroyuki Takatsu |
| author_sort | Hye-Won Shin |
| collection | DOAJ |
| description | During the vesicular trafficking process, cellular membranes undergo dynamic morphological changes, in particular at the vesicle generation and fusion steps. Changes in membrane shape are regulated by small GTPases, coat proteins and other accessory proteins, such as BAR domain-containing proteins. In addition, membrane deformation entails changes in the lipid composition as well as asymmetric distribution of lipids over the two leaflets of the membrane bilayer. Given that P4-ATPases, which catalyze unidirectional flipping of lipid molecules from the exoplasmic to the cytoplasmic leaflets of the bilayer, are crucial for the trafficking of proteins in the secretory and endocytic pathways, changes in the lipid composition are involved in the vesicular trafficking process. Membrane remodeling is under complex regulation that involves the composition and distribution of lipids as well as assembly of proteins. |
| first_indexed | 2024-03-12T08:23:32Z |
| format | Article |
| id | doaj.art-3d95cb22939748889fb6c8eecae7e7d9 |
| institution | Directory Open Access Journal |
| issn | 2077-0375 |
| language | English |
| last_indexed | 2024-03-12T08:23:32Z |
| publishDate | 2012-02-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Membranes |
| spelling | doaj.art-3d95cb22939748889fb6c8eecae7e7d92023-09-02T18:14:36ZengMDPI AGMembranes2077-03752012-02-012111813310.3390/membranes2010118Mechanisms of Membrane Curvature Generation in Membrane TrafficHye-Won ShinKazuhisa NakayamaHiroyuki TakatsuDuring the vesicular trafficking process, cellular membranes undergo dynamic morphological changes, in particular at the vesicle generation and fusion steps. Changes in membrane shape are regulated by small GTPases, coat proteins and other accessory proteins, such as BAR domain-containing proteins. In addition, membrane deformation entails changes in the lipid composition as well as asymmetric distribution of lipids over the two leaflets of the membrane bilayer. Given that P4-ATPases, which catalyze unidirectional flipping of lipid molecules from the exoplasmic to the cytoplasmic leaflets of the bilayer, are crucial for the trafficking of proteins in the secretory and endocytic pathways, changes in the lipid composition are involved in the vesicular trafficking process. Membrane remodeling is under complex regulation that involves the composition and distribution of lipids as well as assembly of proteins.http://www.mdpi.com/2077-0375/2/1/118/membrane traffickingsmall GTPaseBAR domainP4-ATPasemembrane curvature |
| spellingShingle | Hye-Won Shin Kazuhisa Nakayama Hiroyuki Takatsu Mechanisms of Membrane Curvature Generation in Membrane Traffic Membranes membrane trafficking small GTPase BAR domain P4-ATPase membrane curvature |
| title | Mechanisms of Membrane Curvature Generation in Membrane Traffic |
| title_full | Mechanisms of Membrane Curvature Generation in Membrane Traffic |
| title_fullStr | Mechanisms of Membrane Curvature Generation in Membrane Traffic |
| title_full_unstemmed | Mechanisms of Membrane Curvature Generation in Membrane Traffic |
| title_short | Mechanisms of Membrane Curvature Generation in Membrane Traffic |
| title_sort | mechanisms of membrane curvature generation in membrane traffic |
| topic | membrane trafficking small GTPase BAR domain P4-ATPase membrane curvature |
| url | http://www.mdpi.com/2077-0375/2/1/118/ |
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