Plasma Omega-3 Fatty Acids and Risk for Incident Dementia in the UK Biobank Study: A Closer Look
Dietary omega-3 fatty acids are promising nutrients in dementia. Several prospective cohort studies have examined the relationships between circulating omega-3 (an objective biomarker of dietary intake) and incident dementia, the largest to date being a report from the UK Biobank (n = 102,722). Give...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-11-01
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| Series: | Nutrients |
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| Online Access: | https://www.mdpi.com/2072-6643/15/23/4896 |
| _version_ | 1797399764676902912 |
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| author | Aleix Sala-Vila Nathan Tintle Jason Westra William S. Harris |
| author_facet | Aleix Sala-Vila Nathan Tintle Jason Westra William S. Harris |
| author_sort | Aleix Sala-Vila |
| collection | DOAJ |
| description | Dietary omega-3 fatty acids are promising nutrients in dementia. Several prospective cohort studies have examined the relationships between circulating omega-3 (an objective biomarker of dietary intake) and incident dementia, the largest to date being a report from the UK Biobank (n = 102,722). Given the recent release of new metabolomics data from baseline samples from the UK Biobank, we re-examined the association in a much larger sample (n = 267,312) and also focused on associations with total omega-3, docosahexaenoic acid (DHA), and non-DHA omega-3. Using Cox regression models, we observed that the total omega-3 status was inversely related to the risk of Alzheimer’s (Q5 vs. Q1, hazard ratio [95% confidence interval] = 0.87 [0.76; 1.00]) and all-cause dementia (Q5 vs. Q1, 0.79 [0.72; 0.87]). The strongest associations were observed for total omega-3 (and non-DHA omega-3) and all-cause dementia. In prespecified strata, we found stronger associations in men, and in those aged ≥60 years at baseline (vs. those aged 50–59). Thus, in the largest study to date on this topic, we confirmed the favorable relationships between DHA and risk for dementia, and we also found evidence that non-DHA omega-3 may be beneficial. Finally, we have better defined the populations most likely to benefit from omega-3-based interventions. |
| first_indexed | 2024-03-09T01:44:48Z |
| format | Article |
| id | doaj.art-3d9ba7d2de984e07bef89f3960e401e4 |
| institution | Directory Open Access Journal |
| issn | 2072-6643 |
| language | English |
| last_indexed | 2024-03-09T01:44:48Z |
| publishDate | 2023-11-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Nutrients |
| spelling | doaj.art-3d9ba7d2de984e07bef89f3960e401e42023-12-08T15:23:16ZengMDPI AGNutrients2072-66432023-11-011523489610.3390/nu15234896Plasma Omega-3 Fatty Acids and Risk for Incident Dementia in the UK Biobank Study: A Closer LookAleix Sala-Vila0Nathan Tintle1Jason Westra2William S. Harris3The Fatty Acid Research Institute, Sioux Falls, SD 57106, USAThe Fatty Acid Research Institute, Sioux Falls, SD 57106, USAThe Fatty Acid Research Institute, Sioux Falls, SD 57106, USAThe Fatty Acid Research Institute, Sioux Falls, SD 57106, USADietary omega-3 fatty acids are promising nutrients in dementia. Several prospective cohort studies have examined the relationships between circulating omega-3 (an objective biomarker of dietary intake) and incident dementia, the largest to date being a report from the UK Biobank (n = 102,722). Given the recent release of new metabolomics data from baseline samples from the UK Biobank, we re-examined the association in a much larger sample (n = 267,312) and also focused on associations with total omega-3, docosahexaenoic acid (DHA), and non-DHA omega-3. Using Cox regression models, we observed that the total omega-3 status was inversely related to the risk of Alzheimer’s (Q5 vs. Q1, hazard ratio [95% confidence interval] = 0.87 [0.76; 1.00]) and all-cause dementia (Q5 vs. Q1, 0.79 [0.72; 0.87]). The strongest associations were observed for total omega-3 (and non-DHA omega-3) and all-cause dementia. In prespecified strata, we found stronger associations in men, and in those aged ≥60 years at baseline (vs. those aged 50–59). Thus, in the largest study to date on this topic, we confirmed the favorable relationships between DHA and risk for dementia, and we also found evidence that non-DHA omega-3 may be beneficial. Finally, we have better defined the populations most likely to benefit from omega-3-based interventions.https://www.mdpi.com/2072-6643/15/23/4896Alzheimer’s diseasedementiadietfatty acidsdocosahexaenoic acidDHA |
| spellingShingle | Aleix Sala-Vila Nathan Tintle Jason Westra William S. Harris Plasma Omega-3 Fatty Acids and Risk for Incident Dementia in the UK Biobank Study: A Closer Look Nutrients Alzheimer’s disease dementia diet fatty acids docosahexaenoic acid DHA |
| title | Plasma Omega-3 Fatty Acids and Risk for Incident Dementia in the UK Biobank Study: A Closer Look |
| title_full | Plasma Omega-3 Fatty Acids and Risk for Incident Dementia in the UK Biobank Study: A Closer Look |
| title_fullStr | Plasma Omega-3 Fatty Acids and Risk for Incident Dementia in the UK Biobank Study: A Closer Look |
| title_full_unstemmed | Plasma Omega-3 Fatty Acids and Risk for Incident Dementia in the UK Biobank Study: A Closer Look |
| title_short | Plasma Omega-3 Fatty Acids and Risk for Incident Dementia in the UK Biobank Study: A Closer Look |
| title_sort | plasma omega 3 fatty acids and risk for incident dementia in the uk biobank study a closer look |
| topic | Alzheimer’s disease dementia diet fatty acids docosahexaenoic acid DHA |
| url | https://www.mdpi.com/2072-6643/15/23/4896 |
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