An emerging natural antioxidant therapy for COVID‐19 infection patients: Current and future directions
Abstract Severe acute respiratory syndrome coronavirus‐2 (SARS‐CoV‐2) affects millions of people worldwide. The article aims to review the therapeutic perspective on natural antioxidants, their mechanism of action, pharmacokinetics in management and cure of COVID‐19/ SARS‐CoV‐2 infection. We conduct...
| Main Authors: | , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Wiley
2023-09-01
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| Series: | Food Frontiers |
| Subjects: | |
| Online Access: | https://doi.org/10.1002/fft2.207 |
| _version_ | 1797671322276331520 |
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| author | Amit Kumar Shrivastava Prafulla Kumar Sahu Teresa Cecchi Laxmi Shrestha Sanjay Kumar Shah Anamika Gupta Anjan Palikhey Bishal Joshi Pramodkumar P. Gupta Jitendra Upadhyaya Mahendra Paudel Dr Niranjan Koirala |
| author_facet | Amit Kumar Shrivastava Prafulla Kumar Sahu Teresa Cecchi Laxmi Shrestha Sanjay Kumar Shah Anamika Gupta Anjan Palikhey Bishal Joshi Pramodkumar P. Gupta Jitendra Upadhyaya Mahendra Paudel Dr Niranjan Koirala |
| author_sort | Amit Kumar Shrivastava |
| collection | DOAJ |
| description | Abstract Severe acute respiratory syndrome coronavirus‐2 (SARS‐CoV‐2) affects millions of people worldwide. The article aims to review the therapeutic perspective on natural antioxidants, their mechanism of action, pharmacokinetics in management and cure of COVID‐19/ SARS‐CoV‐2 infection. We conducted a literature search including World Health Organization and National Institute of Health guidelines and clinical trials registered with ClinicalTrials.gov limited to antioxidants in COVID‐19 management. Elderly, immunocompromised patients, and others with underlying health conditions or multiple comorbidities have a high mortality rate. Disrupted redox homeostasis and oxidative stress seem to be biological pathways that may increase personal vulnerability to infection. Antioxidants like vitamins C, D, E, epigallocatechin‐3 gallate, and morin have been reported to protect against COVID‐19 disease. Reactive oxygen species are immunological regulatory elements of viral replication. Natural antioxidants exhibit potential action in preventing inflammation and organ dysfunction during viral infection. They also increase glutathione level, oxygenation rate, and immunological responses in the treatment of sepsis and acute respiratory distress syndrome. No wonder the selection of prevention, treatment, and cure of COVID‐19 and SARS‐CoV‐2 mainly depends upon the antiviral and immunoregulatory activity which they possess. Yet, their efficacy against COVID‐19 is of great concern and demands extensive study. |
| first_indexed | 2024-03-11T21:13:39Z |
| format | Article |
| id | doaj.art-3d9bc230b2d2443c86550d0897b87666 |
| institution | Directory Open Access Journal |
| issn | 2643-8429 |
| language | English |
| last_indexed | 2024-03-11T21:13:39Z |
| publishDate | 2023-09-01 |
| publisher | Wiley |
| record_format | Article |
| series | Food Frontiers |
| spelling | doaj.art-3d9bc230b2d2443c86550d0897b876662023-09-29T05:33:43ZengWileyFood Frontiers2643-84292023-09-01431179120510.1002/fft2.207An emerging natural antioxidant therapy for COVID‐19 infection patients: Current and future directionsAmit Kumar Shrivastava0Prafulla Kumar Sahu1Teresa Cecchi2Laxmi Shrestha3Sanjay Kumar Shah4Anamika Gupta5Anjan Palikhey6Bishal Joshi7Pramodkumar P. Gupta8Jitendra Upadhyaya9Mahendra Paudel10Dr Niranjan Koirala11Department of Pharmacology Universal College of Medical Sciences Bhairahawa Rupandehi NepalSchool of Pharmacy Centurion University of Technology and Management Bhubaneswar Odisha IndiaChemistry Department ITT MONTANI Fermo ItalyDepartment of Pharmacology Universal College of Medical Sciences Bhairahawa Rupandehi NepalDepartment of Reproductive MedicineJoint Inter‐national Research Laboratory of Reproduction and DevelopmentChongquing Medical University ChongqingPeople's Republic of ChinaSharjah Institute for Medical Sciences University of Sharjah Sharjah United Arab EmiratesDepartment of Pharmacology Universal College of Medical Sciences Bhairahawa Rupandehi NepalDepartment of Physiology, Universal College of Medical Sciences Bhairahawa Rupandehi NepalSchool of Biotechnology and Bioinformatics D. Y. Patil Deemed to be University, CBD Belapur Navi Mumbai IndiaInstitute of Agriculture and Animal Science Tribhuvan University Chitwan NepalDepartment of Agri‐Botany and Ecology Institute of Agriculture and Animal Science Tribhuvan University Mahendranagar NepalNatural Products Research FacilityGandaki Province Academy of Science and Technology Pokhara, Gandaki Province NepalAbstract Severe acute respiratory syndrome coronavirus‐2 (SARS‐CoV‐2) affects millions of people worldwide. The article aims to review the therapeutic perspective on natural antioxidants, their mechanism of action, pharmacokinetics in management and cure of COVID‐19/ SARS‐CoV‐2 infection. We conducted a literature search including World Health Organization and National Institute of Health guidelines and clinical trials registered with ClinicalTrials.gov limited to antioxidants in COVID‐19 management. Elderly, immunocompromised patients, and others with underlying health conditions or multiple comorbidities have a high mortality rate. Disrupted redox homeostasis and oxidative stress seem to be biological pathways that may increase personal vulnerability to infection. Antioxidants like vitamins C, D, E, epigallocatechin‐3 gallate, and morin have been reported to protect against COVID‐19 disease. Reactive oxygen species are immunological regulatory elements of viral replication. Natural antioxidants exhibit potential action in preventing inflammation and organ dysfunction during viral infection. They also increase glutathione level, oxygenation rate, and immunological responses in the treatment of sepsis and acute respiratory distress syndrome. No wonder the selection of prevention, treatment, and cure of COVID‐19 and SARS‐CoV‐2 mainly depends upon the antiviral and immunoregulatory activity which they possess. Yet, their efficacy against COVID‐19 is of great concern and demands extensive study.https://doi.org/10.1002/fft2.207antioxidantclinical trialsepigallocatechin‐3 gallatemorinquercetinSARS CoV‐2 |
| spellingShingle | Amit Kumar Shrivastava Prafulla Kumar Sahu Teresa Cecchi Laxmi Shrestha Sanjay Kumar Shah Anamika Gupta Anjan Palikhey Bishal Joshi Pramodkumar P. Gupta Jitendra Upadhyaya Mahendra Paudel Dr Niranjan Koirala An emerging natural antioxidant therapy for COVID‐19 infection patients: Current and future directions Food Frontiers antioxidant clinical trials epigallocatechin‐3 gallate morin quercetin SARS CoV‐2 |
| title | An emerging natural antioxidant therapy for COVID‐19 infection patients: Current and future directions |
| title_full | An emerging natural antioxidant therapy for COVID‐19 infection patients: Current and future directions |
| title_fullStr | An emerging natural antioxidant therapy for COVID‐19 infection patients: Current and future directions |
| title_full_unstemmed | An emerging natural antioxidant therapy for COVID‐19 infection patients: Current and future directions |
| title_short | An emerging natural antioxidant therapy for COVID‐19 infection patients: Current and future directions |
| title_sort | emerging natural antioxidant therapy for covid 19 infection patients current and future directions |
| topic | antioxidant clinical trials epigallocatechin‐3 gallate morin quercetin SARS CoV‐2 |
| url | https://doi.org/10.1002/fft2.207 |
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