Ebola virus sequesters IRF3 in viral inclusion bodies to evade host antiviral immunity

Ebola virus sequesters IRF3 in viral inclusion bodies to evade host antiviral immunity

Viral inclusion bodies (IBs) commonly form during the replication of Ebola virus (EBOV) in infected cells, but their role in viral immune evasion has rarely been explored. Here, we found that interferon regulatory factor 3 (IRF3), but not TANK-binding kinase 1 (TBK1) or IκB kinase epsilon (IKKε), wa...

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Bibliographic Details
Main Authors: Lin Zhu, Jing Jin, Tingting Wang, Yong Hu, Hainan Liu, Ting Gao, Qincai Dong, Yanwen Jin, Ping Li, Zijing Liu, Yi Huang, Xuan Liu, Cheng Cao
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2024-01-01
Series:eLife
Subjects:
Ebola virus
VP35
VP24
virus infection
virus inclusion bodies
Online Access:https://elifesciences.org/articles/88122

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