Herpes Zoster Ophthalmicus Clinical Presentation and Risk Factors for Lesion Recovery
Zupeng Xiao, Hanyi Wu, Xin Chen, Xiaoli Chen, Rentao Yu, Aijun Chen Department of Dermatology, The First Affiliated Hospital of Chongqing Medical University, Chongqing, People’s Republic of ChinaCorrespondence: Aijun Chen; Rentao Yu, Department of Dermatology, The First Affiliated Hospital of Chongq...
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| Format: | Article |
| Language: | English |
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Dove Medical Press
2023-12-01
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| Series: | Clinical, Cosmetic and Investigational Dermatology |
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| Online Access: | https://www.dovepress.com/herpes-zoster-ophthalmicus-clinical-presentation-and-risk-factors-for--peer-reviewed-fulltext-article-CCID |
| _version_ | 1797368017389092864 |
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| author | Xiao Z Wu H Chen X Chen X Yu R Chen A |
| author_facet | Xiao Z Wu H Chen X Chen X Yu R Chen A |
| author_sort | Xiao Z |
| collection | DOAJ |
| description | Zupeng Xiao, Hanyi Wu, Xin Chen, Xiaoli Chen, Rentao Yu, Aijun Chen Department of Dermatology, The First Affiliated Hospital of Chongqing Medical University, Chongqing, People’s Republic of ChinaCorrespondence: Aijun Chen; Rentao Yu, Department of Dermatology, The First Affiliated Hospital of Chongqing Medical University, 1 Youyi Road, Yuzhong District, Chongqing, 400016, People’s Republic of China, Tel +86 13062377863; +86-18123303562, Email chenaijun@hospital.cqmu.edu.cn; rentaoyu@hotmail.comPurpose: Herpes zoster ophthalmicus (HZO) causes trouble in patients’ daily life and work. In severe cases, it may even lead to a decrease or loss of vision. To understand the demographic information and ocular symptoms of hospitalized patients with HZO, and to find potential factors related to improvement time of skin rash and duration of ocular symptoms at discharge, we design this study.Patients and Methods: This is a retrospective study. All patients diagnosed with HZO who were hospitalized in the Department of Dermatology of a hospital in Chongqing, China from January 1, 2015 to December 30, 2021 were included in this study. A total of 189 patients were included in this study. Clinical manifestations of the disease during hospitalization, improvement time of ocular skin lesions, and whether ocular skin lesions disappeared completely at discharge were recorded.Results: The most common ocular symptom was eyelid swelling (92.6%), followed by eye pain (48.7%). The most common ocular sign was conjunctivitis (78.3%), followed by keratitis (15.9%). There were 149 cases without residual ocular symptoms and 40 cases with residual ocular symptoms. There was no statistically significant difference in demographic characteristics between the two groups (P> 0.05). Age ≥ 70 years (B=0.381, − 0.061~0.022, P=0.005), use of glucocorticoids (B=0.260, 0.024~0.496, P=0.031), and use of topical antiviral drugs (B=0.380, 0.054~0.705, P=0.023) were factors affecting the time interval from admission to improvement of skin rash. Tearing (HR, OR=4.827, 1.956~11.909, P< 0.001) and blood urea nitrogen (OR=0.787, 0.620– 1.000, P=0.050) were factors influencing residual ocular symptoms.Conclusion: This study could help clinicians gain a deeper understanding of the clinical manifestations and partial influencing factors of HZO patients, which may contribute to future clinical work.Keywords: herpes zoster ophthalmicus, clinical manifestations, disease outcome, risk factors |
| first_indexed | 2024-03-08T17:26:28Z |
| format | Article |
| id | doaj.art-3d9eb97e4cfc454485d7c5f114b0df74 |
| institution | Directory Open Access Journal |
| issn | 1178-7015 |
| language | English |
| last_indexed | 2024-03-08T17:26:28Z |
| publishDate | 2023-12-01 |
| publisher | Dove Medical Press |
| record_format | Article |
| series | Clinical, Cosmetic and Investigational Dermatology |
| spelling | doaj.art-3d9eb97e4cfc454485d7c5f114b0df742024-01-02T19:17:46ZengDove Medical PressClinical, Cosmetic and Investigational Dermatology1178-70152023-12-01Volume 163767377389386Herpes Zoster Ophthalmicus Clinical Presentation and Risk Factors for Lesion RecoveryXiao ZWu HChen XChen XYu RChen AZupeng Xiao, Hanyi Wu, Xin Chen, Xiaoli Chen, Rentao Yu, Aijun Chen Department of Dermatology, The First Affiliated Hospital of Chongqing Medical University, Chongqing, People’s Republic of ChinaCorrespondence: Aijun Chen; Rentao Yu, Department of Dermatology, The First Affiliated Hospital of Chongqing Medical University, 1 Youyi Road, Yuzhong District, Chongqing, 400016, People’s Republic of China, Tel +86 13062377863; +86-18123303562, Email chenaijun@hospital.cqmu.edu.cn; rentaoyu@hotmail.comPurpose: Herpes zoster ophthalmicus (HZO) causes trouble in patients’ daily life and work. In severe cases, it may even lead to a decrease or loss of vision. To understand the demographic information and ocular symptoms of hospitalized patients with HZO, and to find potential factors related to improvement time of skin rash and duration of ocular symptoms at discharge, we design this study.Patients and Methods: This is a retrospective study. All patients diagnosed with HZO who were hospitalized in the Department of Dermatology of a hospital in Chongqing, China from January 1, 2015 to December 30, 2021 were included in this study. A total of 189 patients were included in this study. Clinical manifestations of the disease during hospitalization, improvement time of ocular skin lesions, and whether ocular skin lesions disappeared completely at discharge were recorded.Results: The most common ocular symptom was eyelid swelling (92.6%), followed by eye pain (48.7%). The most common ocular sign was conjunctivitis (78.3%), followed by keratitis (15.9%). There were 149 cases without residual ocular symptoms and 40 cases with residual ocular symptoms. There was no statistically significant difference in demographic characteristics between the two groups (P> 0.05). Age ≥ 70 years (B=0.381, − 0.061~0.022, P=0.005), use of glucocorticoids (B=0.260, 0.024~0.496, P=0.031), and use of topical antiviral drugs (B=0.380, 0.054~0.705, P=0.023) were factors affecting the time interval from admission to improvement of skin rash. Tearing (HR, OR=4.827, 1.956~11.909, P< 0.001) and blood urea nitrogen (OR=0.787, 0.620– 1.000, P=0.050) were factors influencing residual ocular symptoms.Conclusion: This study could help clinicians gain a deeper understanding of the clinical manifestations and partial influencing factors of HZO patients, which may contribute to future clinical work.Keywords: herpes zoster ophthalmicus, clinical manifestations, disease outcome, risk factorshttps://www.dovepress.com/herpes-zoster-ophthalmicus-clinical-presentation-and-risk-factors-for--peer-reviewed-fulltext-article-CCIDherpes zoster ophthalmicusclinical manifestationsdisease outcomerisk factors. |
| spellingShingle | Xiao Z Wu H Chen X Chen X Yu R Chen A Herpes Zoster Ophthalmicus Clinical Presentation and Risk Factors for Lesion Recovery Clinical, Cosmetic and Investigational Dermatology herpes zoster ophthalmicus clinical manifestations disease outcome risk factors. |
| title | Herpes Zoster Ophthalmicus Clinical Presentation and Risk Factors for Lesion Recovery |
| title_full | Herpes Zoster Ophthalmicus Clinical Presentation and Risk Factors for Lesion Recovery |
| title_fullStr | Herpes Zoster Ophthalmicus Clinical Presentation and Risk Factors for Lesion Recovery |
| title_full_unstemmed | Herpes Zoster Ophthalmicus Clinical Presentation and Risk Factors for Lesion Recovery |
| title_short | Herpes Zoster Ophthalmicus Clinical Presentation and Risk Factors for Lesion Recovery |
| title_sort | herpes zoster ophthalmicus clinical presentation and risk factors for lesion recovery |
| topic | herpes zoster ophthalmicus clinical manifestations disease outcome risk factors. |
| url | https://www.dovepress.com/herpes-zoster-ophthalmicus-clinical-presentation-and-risk-factors-for--peer-reviewed-fulltext-article-CCID |
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