Unblinding at disease progression in double-blinded randomized controlled cancer drug clinical trials: A controversy requires more attention
Unblinding at disease progression in double-blinded randomized controlled cancer drug clinical trials is ethical to the patient by ensuring optimal subsequent treatment, but the effect of study treatment on overall survival may be confounded. The views of science and ethics in this issue are controv...
Main Authors: | Wu Dawei, Miao Shuangman, Huang Huiyao, Cui Dandan, Tang Yu, Li Ning |
---|---|
Format: | Article |
Language: | English |
Published: |
Frontiers Media S.A.
2022-12-01
|
Series: | Frontiers in Medicine |
Subjects: | |
Online Access: | https://www.frontiersin.org/articles/10.3389/fmed.2022.1082445/full |
Similar Items
-
Efficacy of unblinded and blinded intermittently scanned continuous glucose monitoring for glycemic control in adults with type 1 diabetes
by: Lixin Guo, et al.
Published: (2023-02-01) -
Implications for blinding in clinical trials with THC-containing cannabinoids based on the CANNA-TICS trial
by: Kirsten R. Müller-Vahl, et al.
Published: (2022-09-01) -
Two-stage Bayesian hierarchical modeling for blinded and unblinded safety monitoring in randomized clinical trials
by: Junhao Liu, et al.
Published: (2020-08-01) -
Blinding properties of methods for supplying drug kits to investigational sites
by: Ron Yu, et al.
Published: (2015-10-01) -
The unblinding of statisticians in clinical trials: commentary on Iflaifel et al., Trials 2023
by: Richard A. Parker
Published: (2023-09-01)