Selective Packaging in Murine Coronavirus Promotes Virulence by Limiting Type I Interferon Responses

Selective Packaging in Murine Coronavirus Promotes Virulence by Limiting Type I Interferon Responses

ABSTRACT Selective packaging is a mechanism used by multiple virus families to specifically incorporate genomic RNA (gRNA) into virions and exclude other types of RNA. Lineage A betacoronaviruses incorporate a 95-bp stem-loop structure, the packaging signal (PS), into the nsp15 locus of ORF1b that i...

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Bibliographic Details
Main Authors: Jeremiah Athmer, Anthony R. Fehr, Matthew E. Grunewald, Wen Qu, D. Lori Wheeler, Kevin W. Graepel, Rudragouda Channappanavar, Aimee Sekine, Dana Saud Aldabeeb, Michael Gale, Mark R. Denison, Stanley Perlman
Format: Article
Language:English
Published: American Society for Microbiology 2018-07-01
Series:mBio
Subjects:
coronavirus
interferon response
murine hepatitis virus
RNA packaging
packaging signal
selective packaging
Online Access:https://journals.asm.org/doi/10.1128/mBio.00272-18

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