Heteroannelation of cyclic ketones: Synthesis, characterization and antitumor evaluation of some condensed azine derivatives
A series of pyrimidine and thiazine derivatives synthesized by one pot reaction of cyclopentanone with a mixture of an aromatic aldehyde namely o-anisaldehyde and different ureas namely urea, guanidine and thiourea, respectively. Furthermore, cycloaddition reaction of active methylene reagents namel...
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| Format: | Article |
| Language: | English |
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Slovenian Chemical Society
2016-07-01
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| Series: | Acta Chimica Slovenica |
| Subjects: | |
| Online Access: | https://journals.matheo.si/index.php/ACSi/article/view/2297 |
| _version_ | 1819315566803943424 |
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| author | Essam A. Soylem Mohammed G. Assy Ghania M Morsi |
| author_facet | Essam A. Soylem Mohammed G. Assy Ghania M Morsi |
| author_sort | Essam A. Soylem |
| collection | DOAJ |
| description | A series of pyrimidine and thiazine derivatives synthesized by one pot reaction of cyclopentanone with a mixture of an aromatic aldehyde namely o-anisaldehyde and different ureas namely urea, guanidine and thiourea, respectively. Furthermore, cycloaddition reaction of active methylene reagents namely acetyl acetone, malononitrile, ethyl cyanoacetate, cyanoacetamide and N-phenyl cyanoacetamide with 2,6-bis(2-methoxybenzylidene)-cyclohexanone afforded chromene and quinoline derivatives in basic medium. The antitumor evaluation of some new compounds against three human cell lines namely MCF-7, NCI-H460 and SF-268 showed significant and moderate activity compared with the positive control doxorubicin. |
| first_indexed | 2024-12-24T10:02:09Z |
| format | Article |
| id | doaj.art-3da3169b45774a3c8e78aedb749026b4 |
| institution | Directory Open Access Journal |
| issn | 1318-0207 1580-3155 |
| language | English |
| last_indexed | 2024-12-24T10:02:09Z |
| publishDate | 2016-07-01 |
| publisher | Slovenian Chemical Society |
| record_format | Article |
| series | Acta Chimica Slovenica |
| spelling | doaj.art-3da3169b45774a3c8e78aedb749026b42022-12-21T17:01:00ZengSlovenian Chemical SocietyActa Chimica Slovenica1318-02071580-31552016-07-0163360961810.17344/acsi.2016.2297377Heteroannelation of cyclic ketones: Synthesis, characterization and antitumor evaluation of some condensed azine derivativesEssam A. Soylem0Mohammed G. Assy1Ghania M Morsi2Department of Chemistry, Faculty of Science, Zagazig University, EgyptDepartment of Chemistry, Faculty of Science, Zagazig University, EgyptDepartment of Chemistry, Faculty of Science, Zagazig University, EgyptA series of pyrimidine and thiazine derivatives synthesized by one pot reaction of cyclopentanone with a mixture of an aromatic aldehyde namely o-anisaldehyde and different ureas namely urea, guanidine and thiourea, respectively. Furthermore, cycloaddition reaction of active methylene reagents namely acetyl acetone, malononitrile, ethyl cyanoacetate, cyanoacetamide and N-phenyl cyanoacetamide with 2,6-bis(2-methoxybenzylidene)-cyclohexanone afforded chromene and quinoline derivatives in basic medium. The antitumor evaluation of some new compounds against three human cell lines namely MCF-7, NCI-H460 and SF-268 showed significant and moderate activity compared with the positive control doxorubicin.https://journals.matheo.si/index.php/ACSi/article/view/2297CyclopentapyrimidineThiazolopyrimidineQuinazolineChromeneAntitumor activity |
| spellingShingle | Essam A. Soylem Mohammed G. Assy Ghania M Morsi Heteroannelation of cyclic ketones: Synthesis, characterization and antitumor evaluation of some condensed azine derivatives Acta Chimica Slovenica Cyclopentapyrimidine Thiazolopyrimidine Quinazoline Chromene Antitumor activity |
| title | Heteroannelation of cyclic ketones: Synthesis, characterization and antitumor evaluation of some condensed azine derivatives |
| title_full | Heteroannelation of cyclic ketones: Synthesis, characterization and antitumor evaluation of some condensed azine derivatives |
| title_fullStr | Heteroannelation of cyclic ketones: Synthesis, characterization and antitumor evaluation of some condensed azine derivatives |
| title_full_unstemmed | Heteroannelation of cyclic ketones: Synthesis, characterization and antitumor evaluation of some condensed azine derivatives |
| title_short | Heteroannelation of cyclic ketones: Synthesis, characterization and antitumor evaluation of some condensed azine derivatives |
| title_sort | heteroannelation of cyclic ketones synthesis characterization and antitumor evaluation of some condensed azine derivatives |
| topic | Cyclopentapyrimidine Thiazolopyrimidine Quinazoline Chromene Antitumor activity |
| url | https://journals.matheo.si/index.php/ACSi/article/view/2297 |
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