MTHFR gene variants and non-MALT lymphoma development in primary Sjogren’s syndrome

MTHFR gene variants and non-MALT lymphoma development in primary Sjogren’s syndrome

Abstract Primary Sjogren’s syndrome (pSS) confers increased risk for non-Hodgkin lymphoma (NHL) development. Two common polymorphisms, the c. 677C > T and c. 1298A > C, of the methylene-tetrahydrofolate reductase (MTHFR) gene, an enzyme essential in DNA synthesis and methylation, have been ass...

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Main Authors: Sofia Fragkioudaki, Adrianos Nezos, Vassilis L. Souliotis, Ilenia Chatziandreou, Angelica A. Saetta, Nikolaos Drakoulis, Athanasios G. Tzioufas, Michael Voulgarelis, Petros P. Sfikakis, Michael Koutsilieris, Mary K. Crow, Haralampos M. Moutsopoulos, Clio P. Mavragani
Format: Article
Language:English
Published: Nature Portfolio 2017-08-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-017-07347-w

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