TMSCl-Catalyzed Tandem Reaction of Dihydroisobenzofuran Acetals with Indoles
A TMSCl-catalyzed tandem reaction of dihydroisobenzofuran acetals with indoles has been developped, which could provide an efficient and straightforward access to various tetrahydroisoquinolones in moderate to excellent yields. This process involved the first addition of the indoles to acetals, foll...
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| Format: | Article |
| Language: | English |
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MDPI AG
2020-04-01
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| Series: | Catalysts |
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| Online Access: | https://www.mdpi.com/2073-4344/10/4/392 |
| _version_ | 1797571582195924992 |
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| author | Ming Zhang Sicong Lu Guofeng Li Liang Hong |
| author_facet | Ming Zhang Sicong Lu Guofeng Li Liang Hong |
| author_sort | Ming Zhang |
| collection | DOAJ |
| description | A TMSCl-catalyzed tandem reaction of dihydroisobenzofuran acetals with indoles has been developped, which could provide an efficient and straightforward access to various tetrahydroisoquinolones in moderate to excellent yields. This process involved the first addition of the indoles to acetals, followed by skeletal rearrangement. |
| first_indexed | 2024-03-10T20:42:45Z |
| format | Article |
| id | doaj.art-3da59481cd4a4cf19863c6bc72c2e438 |
| institution | Directory Open Access Journal |
| issn | 2073-4344 |
| language | English |
| last_indexed | 2024-03-10T20:42:45Z |
| publishDate | 2020-04-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Catalysts |
| spelling | doaj.art-3da59481cd4a4cf19863c6bc72c2e4382023-11-19T20:30:16ZengMDPI AGCatalysts2073-43442020-04-0110439210.3390/catal10040392TMSCl-Catalyzed Tandem Reaction of Dihydroisobenzofuran Acetals with IndolesMing Zhang0Sicong Lu1Guofeng Li2Liang Hong3School of Life Sciences, Lanzhou University, Lanzhou 730000, ChinaSchool of Life Sciences, Lanzhou University, Lanzhou 730000, ChinaGuangdong Key Laboratory of Chiral Molecule and Drug Discovery, School of Pharmaceutical Sciences, Sun Yat-Sen University, Guangzhou 510006, ChinaGuangdong Key Laboratory of Chiral Molecule and Drug Discovery, School of Pharmaceutical Sciences, Sun Yat-Sen University, Guangzhou 510006, ChinaA TMSCl-catalyzed tandem reaction of dihydroisobenzofuran acetals with indoles has been developped, which could provide an efficient and straightforward access to various tetrahydroisoquinolones in moderate to excellent yields. This process involved the first addition of the indoles to acetals, followed by skeletal rearrangement.https://www.mdpi.com/2073-4344/10/4/392organocatalysistandem reactiondihydroisobenzofuran acetalsindolestetrahydroisoquinolones |
| spellingShingle | Ming Zhang Sicong Lu Guofeng Li Liang Hong TMSCl-Catalyzed Tandem Reaction of Dihydroisobenzofuran Acetals with Indoles Catalysts organocatalysis tandem reaction dihydroisobenzofuran acetals indoles tetrahydroisoquinolones |
| title | TMSCl-Catalyzed Tandem Reaction of Dihydroisobenzofuran Acetals with Indoles |
| title_full | TMSCl-Catalyzed Tandem Reaction of Dihydroisobenzofuran Acetals with Indoles |
| title_fullStr | TMSCl-Catalyzed Tandem Reaction of Dihydroisobenzofuran Acetals with Indoles |
| title_full_unstemmed | TMSCl-Catalyzed Tandem Reaction of Dihydroisobenzofuran Acetals with Indoles |
| title_short | TMSCl-Catalyzed Tandem Reaction of Dihydroisobenzofuran Acetals with Indoles |
| title_sort | tmscl catalyzed tandem reaction of dihydroisobenzofuran acetals with indoles |
| topic | organocatalysis tandem reaction dihydroisobenzofuran acetals indoles tetrahydroisoquinolones |
| url | https://www.mdpi.com/2073-4344/10/4/392 |
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