Spastin binds to lipid droplets and affects lipid metabolism.

Spastin binds to lipid droplets and affects lipid metabolism.

Mutations in SPAST, encoding spastin, are the most common cause of autosomal dominant hereditary spastic paraplegia (HSP). HSP is characterized by weakness and spasticity of the lower limbs, owing to progressive retrograde degeneration of the long corticospinal axons. Spastin is a conserved microtub...

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Dettagli Bibliografici
Autori principali: Chrisovalantis Papadopoulos, Genny Orso, Giuseppe Mancuso, Marija Herholz, Sentiljana Gumeni, Nimesha Tadepalle, Christian Jüngst, Anne Tzschichholz, Astrid Schauss, Stefan Höning, Aleksandra Trifunovic, Andrea Daga, Elena I Rugarli
Natura: Articolo
Lingua:English
Pubblicazione: Public Library of Science (PLoS) 2015-04-01
Serie:PLoS Genetics
Accesso online:http://europepmc.org/articles/PMC4395272?pdf=render

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http://europepmc.org/articles/PMC4395272?pdf=render

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