Understanding the role of the Josephin domain in the PolyUb binding and cleavage properties of ataxin-3.

Understanding the role of the Josephin domain in the PolyUb binding and cleavage properties of ataxin-3.

Ataxin-3, the disease protein in the neurodegenerative disorder Spinocerebellar Ataxia Type 3 or Machado Joseph disease, is a cysteine protease implicated in the ubiquitin proteasome pathway. It contains multiple ubiquitin binding sites through which it anchors polyubiquitin chains of different link...

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Bibliographic Details
Main Authors: Giuseppe Nicastro, Sokol V Todi, Ezgi Karaca, Alexandre M J J Bonvin, Henry L Paulson, Annalisa Pastore
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2010-08-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC2928749?pdf=render

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