Magnitude and time course of insulin resistance accumulation with the risk of cardiovascular disease: an 11-years cohort study
Abstract Background The risk of cardiovascular disease (CVD) depended on the magnitude and exposure duration of insulin resistance (IR). This study aimed to investigate the associations of cumulative metabolic score for IR (cumMETS-IR) with incident CVD, and to further explore the modulated effects...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2023-12-01
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| Series: | Cardiovascular Diabetology |
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| Online Access: | https://doi.org/10.1186/s12933-023-02073-2 |
| _version_ | 1827581845199388672 |
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| author | Xue Tian Shuohua Chen Qin Xu Xue Xia Yijun Zhang Penglian Wang Shouling Wu Anxin Wang |
| author_facet | Xue Tian Shuohua Chen Qin Xu Xue Xia Yijun Zhang Penglian Wang Shouling Wu Anxin Wang |
| author_sort | Xue Tian |
| collection | DOAJ |
| description | Abstract Background The risk of cardiovascular disease (CVD) depended on the magnitude and exposure duration of insulin resistance (IR). This study aimed to investigate the associations of cumulative metabolic score for IR (cumMETS-IR) with incident CVD, and to further explore the modulated effects of time course of METS-IR accumulation. Methods We enrolled 47,270 participants without CVD and underwent three examinations during 2006–2010 from the Kailuan study. CumMETS-IR from 2006 to 2010 were calculated as the mean values of METS-IR between consecutive examinations multiplying by time intervals between visits. Time course of METS-IR accumulation was calculated as the slope of METS-IR versus time. Hazard ratios (HRs) and 95% confidence intervals (CIs) for CVD risk were calculated with multivariable-adjusted Cox regressions. Results During a median follow-up of 10.99 years, we identified 3184 cases of incident CVD. The risk of incident CVD increased with increasing cumMETS-IR (HR, 1.77; 95% CI 1.58–1.98 for the Q4 versus Q1 group), exposure duration (HR, 1.60; 95% CI 1.45–1.77 for 6 years versus 0 years), and cumulative burden (HR, 1.49; 95% CI 1.37–1.61 for burden ≥ 0 versus < 0). A positive slope was associated with 14% higher risk of CVD (HR, 1.14; 95% CI 1.07–1.22). When combining cumMETS-IR and slope, those with cumMETS-IR ≥ median (142.78) and slope ≥ 0 had the highest risk of CVD (HR,1.38; 95% CI 1.25–1.53). Conclusions The risk of CVD increased with elevated cumMETS-IR and an increasing trend over time, emphasizing the importance of maintaining optimal METS-IR levels across life span. |
| first_indexed | 2024-03-08T22:42:10Z |
| format | Article |
| id | doaj.art-3daa55940e2d434795bb8c7e72625988 |
| institution | Directory Open Access Journal |
| issn | 1475-2840 |
| language | English |
| last_indexed | 2024-03-08T22:42:10Z |
| publishDate | 2023-12-01 |
| publisher | BMC |
| record_format | Article |
| series | Cardiovascular Diabetology |
| spelling | doaj.art-3daa55940e2d434795bb8c7e726259882023-12-17T12:05:54ZengBMCCardiovascular Diabetology1475-28402023-12-0122111110.1186/s12933-023-02073-2Magnitude and time course of insulin resistance accumulation with the risk of cardiovascular disease: an 11-years cohort studyXue Tian0Shuohua Chen1Qin Xu2Xue Xia3Yijun Zhang4Penglian Wang5Shouling Wu6Anxin Wang7Department of Neurology, Beijing Tiantan Hospital, Capital Medical UniversityDepartment of Cardiology, Kailuan Hospital, North China University of Science and TechnologyDepartment of Neurology, Beijing Tiantan Hospital, Capital Medical UniversityDepartment of Neurology, Beijing Tiantan Hospital, Capital Medical UniversityDepartment of Neurology, Beijing Tiantan Hospital, Capital Medical UniversityDepartment of Neurology, Beijing Tiantan Hospital, Capital Medical UniversityDepartment of Cardiology, Kailuan Hospital, North China University of Science and TechnologyDepartment of Neurology, Beijing Tiantan Hospital, Capital Medical UniversityAbstract Background The risk of cardiovascular disease (CVD) depended on the magnitude and exposure duration of insulin resistance (IR). This study aimed to investigate the associations of cumulative metabolic score for IR (cumMETS-IR) with incident CVD, and to further explore the modulated effects of time course of METS-IR accumulation. Methods We enrolled 47,270 participants without CVD and underwent three examinations during 2006–2010 from the Kailuan study. CumMETS-IR from 2006 to 2010 were calculated as the mean values of METS-IR between consecutive examinations multiplying by time intervals between visits. Time course of METS-IR accumulation was calculated as the slope of METS-IR versus time. Hazard ratios (HRs) and 95% confidence intervals (CIs) for CVD risk were calculated with multivariable-adjusted Cox regressions. Results During a median follow-up of 10.99 years, we identified 3184 cases of incident CVD. The risk of incident CVD increased with increasing cumMETS-IR (HR, 1.77; 95% CI 1.58–1.98 for the Q4 versus Q1 group), exposure duration (HR, 1.60; 95% CI 1.45–1.77 for 6 years versus 0 years), and cumulative burden (HR, 1.49; 95% CI 1.37–1.61 for burden ≥ 0 versus < 0). A positive slope was associated with 14% higher risk of CVD (HR, 1.14; 95% CI 1.07–1.22). When combining cumMETS-IR and slope, those with cumMETS-IR ≥ median (142.78) and slope ≥ 0 had the highest risk of CVD (HR,1.38; 95% CI 1.25–1.53). Conclusions The risk of CVD increased with elevated cumMETS-IR and an increasing trend over time, emphasizing the importance of maintaining optimal METS-IR levels across life span.https://doi.org/10.1186/s12933-023-02073-2Cardiovascular diseaseMetabolic score for insulin resistanceTime course analysisProspective cohort study |
| spellingShingle | Xue Tian Shuohua Chen Qin Xu Xue Xia Yijun Zhang Penglian Wang Shouling Wu Anxin Wang Magnitude and time course of insulin resistance accumulation with the risk of cardiovascular disease: an 11-years cohort study Cardiovascular Diabetology Cardiovascular disease Metabolic score for insulin resistance Time course analysis Prospective cohort study |
| title | Magnitude and time course of insulin resistance accumulation with the risk of cardiovascular disease: an 11-years cohort study |
| title_full | Magnitude and time course of insulin resistance accumulation with the risk of cardiovascular disease: an 11-years cohort study |
| title_fullStr | Magnitude and time course of insulin resistance accumulation with the risk of cardiovascular disease: an 11-years cohort study |
| title_full_unstemmed | Magnitude and time course of insulin resistance accumulation with the risk of cardiovascular disease: an 11-years cohort study |
| title_short | Magnitude and time course of insulin resistance accumulation with the risk of cardiovascular disease: an 11-years cohort study |
| title_sort | magnitude and time course of insulin resistance accumulation with the risk of cardiovascular disease an 11 years cohort study |
| topic | Cardiovascular disease Metabolic score for insulin resistance Time course analysis Prospective cohort study |
| url | https://doi.org/10.1186/s12933-023-02073-2 |
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