The deubiquitinating enzyme complex BRISC regulates Aurora B activation via lysine-63-linked ubiquitination in mitosis
The BRCC36 isopeptidase complex (BRISC) is identified as the deubiquitinating enzyme for Lys63-linked ubiquitination of Aurora B, and hyperactivated Aurora B in the absence of BRISC leads to erroneous chromosome–microtubule attachment during mitosis.
| Main Authors: | , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2022-12-01
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| Series: | Communications Biology |
| Online Access: | https://doi.org/10.1038/s42003-022-04299-4 |
| _version_ | 1811302175785091072 |
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| author | Qin Li Yanfang Ma Fen Chang Yongjie Xu Jingcheng Deng Junyi Duan Wei Jiang Qihua He Luzheng Xu Lijun Zhong Genze Shao Li Li |
| author_facet | Qin Li Yanfang Ma Fen Chang Yongjie Xu Jingcheng Deng Junyi Duan Wei Jiang Qihua He Luzheng Xu Lijun Zhong Genze Shao Li Li |
| author_sort | Qin Li |
| collection | DOAJ |
| description | The BRCC36 isopeptidase complex (BRISC) is identified as the deubiquitinating enzyme for Lys63-linked ubiquitination of Aurora B, and hyperactivated Aurora B in the absence of BRISC leads to erroneous chromosome–microtubule attachment during mitosis. |
| first_indexed | 2024-04-13T07:23:19Z |
| format | Article |
| id | doaj.art-3dab4287fcfb4bd187bd12194cafb1d0 |
| institution | Directory Open Access Journal |
| issn | 2399-3642 |
| language | English |
| last_indexed | 2024-04-13T07:23:19Z |
| publishDate | 2022-12-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Communications Biology |
| spelling | doaj.art-3dab4287fcfb4bd187bd12194cafb1d02022-12-22T02:56:33ZengNature PortfolioCommunications Biology2399-36422022-12-015111610.1038/s42003-022-04299-4The deubiquitinating enzyme complex BRISC regulates Aurora B activation via lysine-63-linked ubiquitination in mitosisQin Li0Yanfang Ma1Fen Chang2Yongjie Xu3Jingcheng Deng4Junyi Duan5Wei Jiang6Qihua He7Luzheng Xu8Lijun Zhong9Genze Shao10Li Li11Department of Cell Biology, School of Basic Medical Sciences, Peking University Health Science CenterDepartment of Cell Biology, School of Basic Medical Sciences, Peking University Health Science CenterDepartment of Cell Biology, School of Basic Medical Sciences, Peking University Health Science CenterDepartment of Cell Biology, School of Basic Medical Sciences, Peking University Health Science CenterDepartment of Cell Biology, School of Basic Medical Sciences, Peking University Health Science CenterDepartment of Cell Biology, School of Basic Medical Sciences, Peking University Health Science CenterDepartment of Biochemistry and Biophysics, School of Basic Medical Sciences, Peking University Health Science CenterCenter of Medical and Health Analysis, Peking University Health Science CenterCenter of Medical and Health Analysis, Peking University Health Science CenterCenter of Medical and Health Analysis, Peking University Health Science CenterDepartment of Cell Biology, School of Basic Medical Sciences, Peking University Health Science CenterDepartment of Cell Biology, School of Basic Medical Sciences, Peking University Health Science CenterThe BRCC36 isopeptidase complex (BRISC) is identified as the deubiquitinating enzyme for Lys63-linked ubiquitination of Aurora B, and hyperactivated Aurora B in the absence of BRISC leads to erroneous chromosome–microtubule attachment during mitosis.https://doi.org/10.1038/s42003-022-04299-4 |
| spellingShingle | Qin Li Yanfang Ma Fen Chang Yongjie Xu Jingcheng Deng Junyi Duan Wei Jiang Qihua He Luzheng Xu Lijun Zhong Genze Shao Li Li The deubiquitinating enzyme complex BRISC regulates Aurora B activation via lysine-63-linked ubiquitination in mitosis Communications Biology |
| title | The deubiquitinating enzyme complex BRISC regulates Aurora B activation via lysine-63-linked ubiquitination in mitosis |
| title_full | The deubiquitinating enzyme complex BRISC regulates Aurora B activation via lysine-63-linked ubiquitination in mitosis |
| title_fullStr | The deubiquitinating enzyme complex BRISC regulates Aurora B activation via lysine-63-linked ubiquitination in mitosis |
| title_full_unstemmed | The deubiquitinating enzyme complex BRISC regulates Aurora B activation via lysine-63-linked ubiquitination in mitosis |
| title_short | The deubiquitinating enzyme complex BRISC regulates Aurora B activation via lysine-63-linked ubiquitination in mitosis |
| title_sort | deubiquitinating enzyme complex brisc regulates aurora b activation via lysine 63 linked ubiquitination in mitosis |
| url | https://doi.org/10.1038/s42003-022-04299-4 |
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