The deubiquitinating enzyme complex BRISC regulates Aurora B activation via lysine-63-linked ubiquitination in mitosis

The deubiquitinating enzyme complex BRISC regulates Aurora B activation via lysine-63-linked ubiquitination in mitosis

The BRCC36 isopeptidase complex (BRISC) is identified as the deubiquitinating enzyme for Lys63-linked ubiquitination of Aurora B, and hyperactivated Aurora B in the absence of BRISC leads to erroneous chromosome–microtubule attachment during mitosis.

Bibliographic Details
Main Authors: Qin Li, Yanfang Ma, Fen Chang, Yongjie Xu, Jingcheng Deng, Junyi Duan, Wei Jiang, Qihua He, Luzheng Xu, Lijun Zhong, Genze Shao, Li Li
Format: Article
Language:English
Published: Nature Portfolio 2022-12-01
Series:Communications Biology
Online Access:https://doi.org/10.1038/s42003-022-04299-4

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