Causal associations between circulating inflammatory cytokines and blinding eye diseases: a bidirectional Mendelian randomization analysis
BackgroundPrevious studies have explored the associations between circulating inflammatory cytokines and blinding eye diseases, including glaucoma, cataract and macular degeneration. However, the causality of these associations remains controversial. This study employs a bidirectional Mendelian rand...
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| Format: | Article |
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Frontiers Media S.A.
2024-01-01
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| Series: | Frontiers in Aging Neuroscience |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fnagi.2024.1324651/full |
| _version_ | 1797348604079243264 |
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| author | Menghao Teng Jiachen Wang Xiaochen Su Ye Tian Xiaomin Ye Yingang Zhang |
| author_facet | Menghao Teng Jiachen Wang Xiaochen Su Ye Tian Xiaomin Ye Yingang Zhang |
| author_sort | Menghao Teng |
| collection | DOAJ |
| description | BackgroundPrevious studies have explored the associations between circulating inflammatory cytokines and blinding eye diseases, including glaucoma, cataract and macular degeneration. However, the causality of these associations remains controversial. This study employs a bidirectional Mendelian randomization (MR) study to investigate the causal relationships between 41 circulating inflammatory cytokines and these blinding eye diseases.MethodsSummary data for glaucoma, cataract, macular degeneration and 41 circulating inflammatory cytokines were publicly available. The inverse variance weighted (IVW) method was employed as the main analysis method. Additionally, various sensitivity tests, including MR–Egger regression, weighted median, weight mode, Cochran’s Q test, MR pleiotropy Residual Sum and Outlier test, and leave-one-out test, were conducted to evaluate sensitivity and stability of results.ResultsThe IVW analysis identified six circulating inflammatory cytokines causally associated with the risk of blinding eye diseases: Monokine induced by interferon-gamma (MIG) for glaucoma, interleukin-1 receptor antagonist (IL-1ra), IL-6, IL-10, and platelet derived growth factor BB (PDGFbb) for cataract, and MIG and hepatocyte growth factor (HGF) for macular degeneration. However, it is noteworthy that none of these associations remained significant after Bonferroni correction (p < 0.0004). Reverse MR analyses indicated that cataract may lead to a decrease in vascular endothelial growth factor (VEGF) levels (OR: 3.326 × 10−04, 95% CI: 5.198 × 10−07 − 2.129 × 10−01, p = 0.0151).ConclusionThis study highlights the potential roles of specific inflammatory cytokines in the development of glaucoma, cataract and macular degeneration. Moreover, it suggests that VEGF is likely to be involved in cataract development downstream. These findings offer insights for early prevention and novel therapeutic strategies for these blinding eye diseases. |
| first_indexed | 2024-03-08T12:08:30Z |
| format | Article |
| id | doaj.art-3daeee289302474eb2be29c752311f79 |
| institution | Directory Open Access Journal |
| issn | 1663-4365 |
| language | English |
| last_indexed | 2024-03-08T12:08:30Z |
| publishDate | 2024-01-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Aging Neuroscience |
| spelling | doaj.art-3daeee289302474eb2be29c752311f792024-01-23T04:16:49ZengFrontiers Media S.A.Frontiers in Aging Neuroscience1663-43652024-01-011610.3389/fnagi.2024.13246511324651Causal associations between circulating inflammatory cytokines and blinding eye diseases: a bidirectional Mendelian randomization analysisMenghao Teng0Jiachen Wang1Xiaochen Su2Ye Tian3Xiaomin Ye4Yingang Zhang5Department of Orthopedics, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, ChinaDepartment of Joint Surgery, HongHui Hospital, Xi'an Jiaotong University, Xi'an, ChinaDepartment of Orthopedics, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, ChinaHealthy Food Evaluation Research Center, West China School of Public Health and West China Fourth Hospital, Sichuan University, Chengdu, ChinaSchool of Electronic Information and Artiffcial Intelligence, Shaanxi University of Science and Technology, Xi'an, ChinaDepartment of Orthopedics, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, ChinaBackgroundPrevious studies have explored the associations between circulating inflammatory cytokines and blinding eye diseases, including glaucoma, cataract and macular degeneration. However, the causality of these associations remains controversial. This study employs a bidirectional Mendelian randomization (MR) study to investigate the causal relationships between 41 circulating inflammatory cytokines and these blinding eye diseases.MethodsSummary data for glaucoma, cataract, macular degeneration and 41 circulating inflammatory cytokines were publicly available. The inverse variance weighted (IVW) method was employed as the main analysis method. Additionally, various sensitivity tests, including MR–Egger regression, weighted median, weight mode, Cochran’s Q test, MR pleiotropy Residual Sum and Outlier test, and leave-one-out test, were conducted to evaluate sensitivity and stability of results.ResultsThe IVW analysis identified six circulating inflammatory cytokines causally associated with the risk of blinding eye diseases: Monokine induced by interferon-gamma (MIG) for glaucoma, interleukin-1 receptor antagonist (IL-1ra), IL-6, IL-10, and platelet derived growth factor BB (PDGFbb) for cataract, and MIG and hepatocyte growth factor (HGF) for macular degeneration. However, it is noteworthy that none of these associations remained significant after Bonferroni correction (p < 0.0004). Reverse MR analyses indicated that cataract may lead to a decrease in vascular endothelial growth factor (VEGF) levels (OR: 3.326 × 10−04, 95% CI: 5.198 × 10−07 − 2.129 × 10−01, p = 0.0151).ConclusionThis study highlights the potential roles of specific inflammatory cytokines in the development of glaucoma, cataract and macular degeneration. Moreover, it suggests that VEGF is likely to be involved in cataract development downstream. These findings offer insights for early prevention and novel therapeutic strategies for these blinding eye diseases.https://www.frontiersin.org/articles/10.3389/fnagi.2024.1324651/fullcirculating inflammatory cytokinesglaucomacataractmacular degenerationmendelian randomizationgenome-wide association study |
| spellingShingle | Menghao Teng Jiachen Wang Xiaochen Su Ye Tian Xiaomin Ye Yingang Zhang Causal associations between circulating inflammatory cytokines and blinding eye diseases: a bidirectional Mendelian randomization analysis Frontiers in Aging Neuroscience circulating inflammatory cytokines glaucoma cataract macular degeneration mendelian randomization genome-wide association study |
| title | Causal associations between circulating inflammatory cytokines and blinding eye diseases: a bidirectional Mendelian randomization analysis |
| title_full | Causal associations between circulating inflammatory cytokines and blinding eye diseases: a bidirectional Mendelian randomization analysis |
| title_fullStr | Causal associations between circulating inflammatory cytokines and blinding eye diseases: a bidirectional Mendelian randomization analysis |
| title_full_unstemmed | Causal associations between circulating inflammatory cytokines and blinding eye diseases: a bidirectional Mendelian randomization analysis |
| title_short | Causal associations between circulating inflammatory cytokines and blinding eye diseases: a bidirectional Mendelian randomization analysis |
| title_sort | causal associations between circulating inflammatory cytokines and blinding eye diseases a bidirectional mendelian randomization analysis |
| topic | circulating inflammatory cytokines glaucoma cataract macular degeneration mendelian randomization genome-wide association study |
| url | https://www.frontiersin.org/articles/10.3389/fnagi.2024.1324651/full |
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