Biophysical properties of presynaptic short-term plasticity inhippocampal neurons: insights from electrophysiology, imagingand mechanistic models
Hippocampal neurons show different types of short-term plasticity (STP). Some exhibit facilitation of their synaptic responses and others depression. In this review we discuss presynaptic biophysical properties behind heterogeneity in STP in hippocampal neurons such as alterations in vesicle priming...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2014-05-01
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| Series: | Frontiers in Cellular Neuroscience |
| Subjects: | |
| Online Access: | http://journal.frontiersin.org/Journal/10.3389/fncel.2014.00141/full |
| _version_ | 1811240698122338304 |
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| author | Ranjita eDutta Roy Ranjita eDutta Roy Melanie I Stefan Christian eRosenmund |
| author_facet | Ranjita eDutta Roy Ranjita eDutta Roy Melanie I Stefan Christian eRosenmund |
| author_sort | Ranjita eDutta Roy |
| collection | DOAJ |
| description | Hippocampal neurons show different types of short-term plasticity (STP). Some exhibit facilitation of their synaptic responses and others depression. In this review we discuss presynaptic biophysical properties behind heterogeneity in STP in hippocampal neurons such as alterations in vesicle priming and docking, fusion, neurotransmitter filling and vesicle replenishment. We look into what types of information electrophysiology, imaging and mechanistic models have given about the time scales and relative impact of the different properties on STP with an emphasis on the use of mechanistic models as complementary tools to experimental procedures. Taken together this tells us that it is possible for a multitude of different mechanisms to underlie the same STP pattern, even though some are more important in specific cases, and that mechanistic models can be used to integrate the biophysical properties to see which mechanisms are more important in specific cases of STP. |
| first_indexed | 2024-04-12T13:24:53Z |
| format | Article |
| id | doaj.art-3db063bab20d44fca4adb9c1c56ed32f |
| institution | Directory Open Access Journal |
| issn | 1662-5102 |
| language | English |
| last_indexed | 2024-04-12T13:24:53Z |
| publishDate | 2014-05-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Cellular Neuroscience |
| spelling | doaj.art-3db063bab20d44fca4adb9c1c56ed32f2022-12-22T03:31:21ZengFrontiers Media S.A.Frontiers in Cellular Neuroscience1662-51022014-05-01810.3389/fncel.2014.0014191359Biophysical properties of presynaptic short-term plasticity inhippocampal neurons: insights from electrophysiology, imagingand mechanistic modelsRanjita eDutta Roy0Ranjita eDutta Roy1Melanie I Stefan2Christian eRosenmund3Karolinska InstitutetCharite UniversitatsmedizinHarvard Medical SchoolCharite UniversitatsmedizinHippocampal neurons show different types of short-term plasticity (STP). Some exhibit facilitation of their synaptic responses and others depression. In this review we discuss presynaptic biophysical properties behind heterogeneity in STP in hippocampal neurons such as alterations in vesicle priming and docking, fusion, neurotransmitter filling and vesicle replenishment. We look into what types of information electrophysiology, imaging and mechanistic models have given about the time scales and relative impact of the different properties on STP with an emphasis on the use of mechanistic models as complementary tools to experimental procedures. Taken together this tells us that it is possible for a multitude of different mechanisms to underlie the same STP pattern, even though some are more important in specific cases, and that mechanistic models can be used to integrate the biophysical properties to see which mechanisms are more important in specific cases of STP.http://journal.frontiersin.org/Journal/10.3389/fncel.2014.00141/fullElectrophysiologyimagingshort-term plasticitybiophysical modelshippocampal neuronsvesicle dynamics |
| spellingShingle | Ranjita eDutta Roy Ranjita eDutta Roy Melanie I Stefan Christian eRosenmund Biophysical properties of presynaptic short-term plasticity inhippocampal neurons: insights from electrophysiology, imagingand mechanistic models Frontiers in Cellular Neuroscience Electrophysiology imaging short-term plasticity biophysical models hippocampal neurons vesicle dynamics |
| title | Biophysical properties of presynaptic short-term plasticity inhippocampal neurons: insights from electrophysiology, imagingand mechanistic models |
| title_full | Biophysical properties of presynaptic short-term plasticity inhippocampal neurons: insights from electrophysiology, imagingand mechanistic models |
| title_fullStr | Biophysical properties of presynaptic short-term plasticity inhippocampal neurons: insights from electrophysiology, imagingand mechanistic models |
| title_full_unstemmed | Biophysical properties of presynaptic short-term plasticity inhippocampal neurons: insights from electrophysiology, imagingand mechanistic models |
| title_short | Biophysical properties of presynaptic short-term plasticity inhippocampal neurons: insights from electrophysiology, imagingand mechanistic models |
| title_sort | biophysical properties of presynaptic short term plasticity inhippocampal neurons insights from electrophysiology imagingand mechanistic models |
| topic | Electrophysiology imaging short-term plasticity biophysical models hippocampal neurons vesicle dynamics |
| url | http://journal.frontiersin.org/Journal/10.3389/fncel.2014.00141/full |
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