Effect of Feeding <i>Saccharomyces cerevisiae boulardii</i> CNCM I-1079 to Sows and Piglets on Piglets’ Immune Response after Vaccination against <i>Actinobacillus pleuropneumoniae</i>
The aim of this study was to assess the effect that feeding <i>Saccharomyces cerevisiae boulardii</i> CNCM I-1079 (LSB) to lactating sows and their progeny has on inflammatory response and mucosal immunity after vaccination against <i>Actinobacillus pleuropneumoniae.</i> Sixt...
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MDPI AG
2022-09-01
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| Online Access: | https://www.mdpi.com/2076-2615/12/19/2513 |
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| author | Fernando Bravo de Laguna Carolina Cabrera Ana Belén González Clara de Pascual Francisco José Pallarés Eric Chevaux Mathieu Castex David Saornil Pierre Lebreton Guillermo Ramis |
| author_facet | Fernando Bravo de Laguna Carolina Cabrera Ana Belén González Clara de Pascual Francisco José Pallarés Eric Chevaux Mathieu Castex David Saornil Pierre Lebreton Guillermo Ramis |
| author_sort | Fernando Bravo de Laguna |
| collection | DOAJ |
| description | The aim of this study was to assess the effect that feeding <i>Saccharomyces cerevisiae boulardii</i> CNCM I-1079 (LSB) to lactating sows and their progeny has on inflammatory response and mucosal immunity after vaccination against <i>Actinobacillus pleuropneumoniae.</i> Sixty-seven Danbred sows were allotted into two treatments when they entered the farrowing room seven days before the expected farrowing date: control (CON: lactation diet) and LSB (CON + 12 × 10<sup>9</sup> colony forming units (CFU)/d until weaning). At weaning, piglets were equally allotted into two experimental diets according to sow diet: control (CON: 2-phase post-weaning diets) and LSB (CON + 2 × 10<sup>9</sup> CFU/kg and 1 × 10<sup>9</sup> CFU/kg in phases 1 and 2, respectively). The piglets were vaccinated at days 26 and 49 post-weaning. Growth performance and number of IgA producing cells and cytokine’s gene expression in lung, lymph node, and intestine samples at day 70 post-weaning were assessed and analyzed in SPSS Statistics 26: performance with a general linear model with sex, room, sow diet, piglet diet, and their interactions as main effects, and immunity with a Kruskal–Wallis test for k unrelated samples. Piglets from LSB-fed sows displayed a higher average daily gain (ADG; <i>p</i> < 0.01) and a heavier body weight (BW; <i>p</i> < 0.05) during lactation, tended (<i>p</i> < 0.1) to be heavier at day 49, and to have a higher ADG between days 26 and 49; had fewer number of IgA producing cells in the lymph node (<i>p</i> < 0.05); and all the cytokines studied were significantly under-regulated (<i>p</i> < 0.05) in the lung. It is concluded that feeding <i>Saccharomyces cerevisiae boulardii</i> CNCM I-1079 to sows improved piglet performance during lactation and showed a clear reduction in the inflammatory status of the lungs after vaccination against <i>A. pleuropneumoniae</i>, suggesting that there was a maternal imprinting effect on mucosal protection and a cross-talk between the gut microbiota and the lung. |
| first_indexed | 2024-03-09T22:09:14Z |
| format | Article |
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| institution | Directory Open Access Journal |
| issn | 2076-2615 |
| language | English |
| last_indexed | 2024-03-09T22:09:14Z |
| publishDate | 2022-09-01 |
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| spelling | doaj.art-3db0f63f685d4c7eb1dc22b7de67c2522023-11-23T19:34:55ZengMDPI AGAnimals2076-26152022-09-011219251310.3390/ani12192513Effect of Feeding <i>Saccharomyces cerevisiae boulardii</i> CNCM I-1079 to Sows and Piglets on Piglets’ Immune Response after Vaccination against <i>Actinobacillus pleuropneumoniae</i>Fernando Bravo de Laguna0Carolina Cabrera1Ana Belén González2Clara de Pascual3Francisco José Pallarés4Eric Chevaux5Mathieu Castex6David Saornil7Pierre Lebreton8Guillermo Ramis9Lallemand SAS, 31702 Blagnac, FranceDepartment of Animal Production, Faculty of Veterinary Medicine, University of Murcia, 30100 Murcia, SpainDepartment of Animal Production, Faculty of Veterinary Medicine, University of Murcia, 30100 Murcia, SpainDepartment of Animal Production, Faculty of Veterinary Medicine, University of Murcia, 30100 Murcia, SpainDepartment of Anatomy and Comparative Pathology, Faculty of Veterinary Medicine, University of Córdoba, 14071 Córdoba, SpainLallemand SAS, 31702 Blagnac, FranceLallemand SAS, 31702 Blagnac, FranceLallemand SAS, 31702 Blagnac, FranceLallemand SAS, 31702 Blagnac, FranceDepartment of Animal Production, Faculty of Veterinary Medicine, University of Murcia, 30100 Murcia, SpainThe aim of this study was to assess the effect that feeding <i>Saccharomyces cerevisiae boulardii</i> CNCM I-1079 (LSB) to lactating sows and their progeny has on inflammatory response and mucosal immunity after vaccination against <i>Actinobacillus pleuropneumoniae.</i> Sixty-seven Danbred sows were allotted into two treatments when they entered the farrowing room seven days before the expected farrowing date: control (CON: lactation diet) and LSB (CON + 12 × 10<sup>9</sup> colony forming units (CFU)/d until weaning). At weaning, piglets were equally allotted into two experimental diets according to sow diet: control (CON: 2-phase post-weaning diets) and LSB (CON + 2 × 10<sup>9</sup> CFU/kg and 1 × 10<sup>9</sup> CFU/kg in phases 1 and 2, respectively). The piglets were vaccinated at days 26 and 49 post-weaning. Growth performance and number of IgA producing cells and cytokine’s gene expression in lung, lymph node, and intestine samples at day 70 post-weaning were assessed and analyzed in SPSS Statistics 26: performance with a general linear model with sex, room, sow diet, piglet diet, and their interactions as main effects, and immunity with a Kruskal–Wallis test for k unrelated samples. Piglets from LSB-fed sows displayed a higher average daily gain (ADG; <i>p</i> < 0.01) and a heavier body weight (BW; <i>p</i> < 0.05) during lactation, tended (<i>p</i> < 0.1) to be heavier at day 49, and to have a higher ADG between days 26 and 49; had fewer number of IgA producing cells in the lymph node (<i>p</i> < 0.05); and all the cytokines studied were significantly under-regulated (<i>p</i> < 0.05) in the lung. It is concluded that feeding <i>Saccharomyces cerevisiae boulardii</i> CNCM I-1079 to sows improved piglet performance during lactation and showed a clear reduction in the inflammatory status of the lungs after vaccination against <i>A. pleuropneumoniae</i>, suggesting that there was a maternal imprinting effect on mucosal protection and a cross-talk between the gut microbiota and the lung.https://www.mdpi.com/2076-2615/12/19/2513<i>Saccharomyces cerevisiae boulardii</i>gut-lung axismaternal imprintingcytokinesweanling piglets |
| spellingShingle | Fernando Bravo de Laguna Carolina Cabrera Ana Belén González Clara de Pascual Francisco José Pallarés Eric Chevaux Mathieu Castex David Saornil Pierre Lebreton Guillermo Ramis Effect of Feeding <i>Saccharomyces cerevisiae boulardii</i> CNCM I-1079 to Sows and Piglets on Piglets’ Immune Response after Vaccination against <i>Actinobacillus pleuropneumoniae</i> Animals <i>Saccharomyces cerevisiae boulardii</i> gut-lung axis maternal imprinting cytokines weanling piglets |
| title | Effect of Feeding <i>Saccharomyces cerevisiae boulardii</i> CNCM I-1079 to Sows and Piglets on Piglets’ Immune Response after Vaccination against <i>Actinobacillus pleuropneumoniae</i> |
| title_full | Effect of Feeding <i>Saccharomyces cerevisiae boulardii</i> CNCM I-1079 to Sows and Piglets on Piglets’ Immune Response after Vaccination against <i>Actinobacillus pleuropneumoniae</i> |
| title_fullStr | Effect of Feeding <i>Saccharomyces cerevisiae boulardii</i> CNCM I-1079 to Sows and Piglets on Piglets’ Immune Response after Vaccination against <i>Actinobacillus pleuropneumoniae</i> |
| title_full_unstemmed | Effect of Feeding <i>Saccharomyces cerevisiae boulardii</i> CNCM I-1079 to Sows and Piglets on Piglets’ Immune Response after Vaccination against <i>Actinobacillus pleuropneumoniae</i> |
| title_short | Effect of Feeding <i>Saccharomyces cerevisiae boulardii</i> CNCM I-1079 to Sows and Piglets on Piglets’ Immune Response after Vaccination against <i>Actinobacillus pleuropneumoniae</i> |
| title_sort | effect of feeding i saccharomyces cerevisiae boulardii i cncm i 1079 to sows and piglets on piglets immune response after vaccination against i actinobacillus pleuropneumoniae i |
| topic | <i>Saccharomyces cerevisiae boulardii</i> gut-lung axis maternal imprinting cytokines weanling piglets |
| url | https://www.mdpi.com/2076-2615/12/19/2513 |
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