Sustained release from a metal - Analgesics entrapped within biocidal silver
Abstract Matrices for sustained release of drugs have been based on polymers, biomaterials and oxides. The use of the major family of metals as matrices for sustained release is, to the best of our knowledge, unknown. In this context we describe a new family of bio-composites for sustained release o...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2017-06-01
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| Series: | Scientific Reports |
| Online Access: | https://doi.org/10.1038/s41598-017-03195-w |
| _version_ | 1818681247669420032 |
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| author | Barak Menagen Rami Pedahzur David Avnir |
| author_facet | Barak Menagen Rami Pedahzur David Avnir |
| author_sort | Barak Menagen |
| collection | DOAJ |
| description | Abstract Matrices for sustained release of drugs have been based on polymers, biomaterials and oxides. The use of the major family of metals as matrices for sustained release is, to the best of our knowledge, unknown. In this context we describe a new family of bio-composites for sustained release of drugs, namely analgesic drugs entrapped within metallic silver. Synthetic methodologies were developed for the preparation of ibuprofen@Ag, naproxen@Ag, tramadol@Ag and bupivacaine@Ag composites. Detailed kinetic analysis of the release of the drugs from within the metal, is provided, demonstrating that metals can indeed serve as reservoirs for drug release. The metal in our case acts not only as a drug releasing source, but also as an antibacterial agent and this property of the composites was studied. Unexpectedly, it was found that the entrapment of the analgesics within silver, dramatically enhances the growth inhibition activity of wild type Pseudomonas aeruginosa, exceeding by far the inhibition activity of the separate components. A mechanism for this interesting observation is provided. The strong antimicrobial activity combined with the analgesic activity open the road for future applications of these materials as dual-purpose components in wound treatment. |
| first_indexed | 2024-12-17T09:59:55Z |
| format | Article |
| id | doaj.art-3db453190e7b4901b6cbdff003104939 |
| institution | Directory Open Access Journal |
| issn | 2045-2322 |
| language | English |
| last_indexed | 2024-12-17T09:59:55Z |
| publishDate | 2017-06-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Scientific Reports |
| spelling | doaj.art-3db453190e7b4901b6cbdff0031049392022-12-21T21:53:19ZengNature PortfolioScientific Reports2045-23222017-06-017111110.1038/s41598-017-03195-wSustained release from a metal - Analgesics entrapped within biocidal silverBarak Menagen0Rami Pedahzur1David Avnir2Institute of Chemistry and the Center for Nanoscience and Nanotechnology, the Hebrew University of JerusalemDepartment of Environmental Health, Hadassah Academic CollegeInstitute of Chemistry and the Center for Nanoscience and Nanotechnology, the Hebrew University of JerusalemAbstract Matrices for sustained release of drugs have been based on polymers, biomaterials and oxides. The use of the major family of metals as matrices for sustained release is, to the best of our knowledge, unknown. In this context we describe a new family of bio-composites for sustained release of drugs, namely analgesic drugs entrapped within metallic silver. Synthetic methodologies were developed for the preparation of ibuprofen@Ag, naproxen@Ag, tramadol@Ag and bupivacaine@Ag composites. Detailed kinetic analysis of the release of the drugs from within the metal, is provided, demonstrating that metals can indeed serve as reservoirs for drug release. The metal in our case acts not only as a drug releasing source, but also as an antibacterial agent and this property of the composites was studied. Unexpectedly, it was found that the entrapment of the analgesics within silver, dramatically enhances the growth inhibition activity of wild type Pseudomonas aeruginosa, exceeding by far the inhibition activity of the separate components. A mechanism for this interesting observation is provided. The strong antimicrobial activity combined with the analgesic activity open the road for future applications of these materials as dual-purpose components in wound treatment.https://doi.org/10.1038/s41598-017-03195-w |
| spellingShingle | Barak Menagen Rami Pedahzur David Avnir Sustained release from a metal - Analgesics entrapped within biocidal silver Scientific Reports |
| title | Sustained release from a metal - Analgesics entrapped within biocidal silver |
| title_full | Sustained release from a metal - Analgesics entrapped within biocidal silver |
| title_fullStr | Sustained release from a metal - Analgesics entrapped within biocidal silver |
| title_full_unstemmed | Sustained release from a metal - Analgesics entrapped within biocidal silver |
| title_short | Sustained release from a metal - Analgesics entrapped within biocidal silver |
| title_sort | sustained release from a metal analgesics entrapped within biocidal silver |
| url | https://doi.org/10.1038/s41598-017-03195-w |
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