Risk predictors of early recurrence in women with epithelial ovarian cancer in Lagos, Nigeria
INTRODUCTION: Epithelial ovarian cancer (EOC) is the most lethal gynaecological cancer with a recurrence rate as high as 85% after an initial treatment. However, there are currently no reliable means of predicting the risk of recurrence after first-line treatment. This study investigated the risk fa...
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| Format: | Article |
| Language: | English |
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The Pan African Medical Journal
2020-08-01
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| Series: | The Pan African Medical Journal |
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https://www.panafrican-med-journal.com/content/article/36/272/pdf/272.pdf
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| _version_ | 1818916816250994688 |
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| author | Kehinde Sharafadeen Okunade Imoleayo Elijah Adetuyi Muisi Adenekan Ephraim Ohazurike Rose Ihuoma Anorlu |
| author_facet | Kehinde Sharafadeen Okunade Imoleayo Elijah Adetuyi Muisi Adenekan Ephraim Ohazurike Rose Ihuoma Anorlu |
| author_sort | Kehinde Sharafadeen Okunade |
| collection | DOAJ |
| description | INTRODUCTION: Epithelial ovarian cancer (EOC) is the most lethal gynaecological cancer with a recurrence rate as high as 85% after an initial treatment. However, there are currently no reliable means of predicting the risk of recurrence after first-line treatment. This study investigated the risk factors that predict early recurrence of EOC after primary treatment among women in Lagos, Nigeria. METHODS: this was a retrospective cohort study involving the review of all histologically confirmed EOC patients managed at the Lagos University Teaching Hospital, Lagos, Nigeria over a 7-year period from January 2010 to December 2016. A study proforma was used to retrieve relevant information and descriptive statistics were computed for all data. The associations between variables were tested and multivariate analysis was done to adjust for all the possible characteristics that predict early EOC recurrence. RESULTS: the rate of recurrence of EOC was 76.4%. Suboptimal debulking surgery is the only independent predictor of early tumour recurrence. CONCLUSION: women should be adequately counselled and encouraged to report their symptoms early to ensure optimal primary treatment. Strategic efforts should also be made to further improve subspecialty training programs and skills development in gynaecological oncology in Nigeria and sub-Saharan Africa. |
| first_indexed | 2024-12-20T00:24:11Z |
| format | Article |
| id | doaj.art-3db4e90c766940ca8b4298cfaab703c6 |
| institution | Directory Open Access Journal |
| issn | 1937-8688 1937-8688 |
| language | English |
| last_indexed | 2024-12-20T00:24:11Z |
| publishDate | 2020-08-01 |
| publisher | The Pan African Medical Journal |
| record_format | Article |
| series | The Pan African Medical Journal |
| spelling | doaj.art-3db4e90c766940ca8b4298cfaab703c62022-12-21T20:00:07ZengThe Pan African Medical JournalThe Pan African Medical Journal1937-86881937-86882020-08-013627210.11604/pamj.2020.36.272.1782717827Risk predictors of early recurrence in women with epithelial ovarian cancer in Lagos, NigeriaKehinde Sharafadeen Okunade0Imoleayo Elijah Adetuyi1Muisi Adenekan2Ephraim Ohazurike3Rose Ihuoma Anorlu4 Department of Obstetrics and Gynaecology, College of Medicine, University of Lagos, Lagos, Nigeria Department of Obstetrics and Gynaecology, Lagos University Teaching Hospital, Lagos, Nigeria Department of Obstetrics and Gynaecology, Lagos University Teaching Hospital, Lagos, Nigeria Department of Obstetrics and Gynaecology, Lagos University Teaching Hospital, Lagos, Nigeria Department of Obstetrics and Gynaecology, College of Medicine, University of Lagos, Lagos, Nigeria INTRODUCTION: Epithelial ovarian cancer (EOC) is the most lethal gynaecological cancer with a recurrence rate as high as 85% after an initial treatment. However, there are currently no reliable means of predicting the risk of recurrence after first-line treatment. This study investigated the risk factors that predict early recurrence of EOC after primary treatment among women in Lagos, Nigeria. METHODS: this was a retrospective cohort study involving the review of all histologically confirmed EOC patients managed at the Lagos University Teaching Hospital, Lagos, Nigeria over a 7-year period from January 2010 to December 2016. A study proforma was used to retrieve relevant information and descriptive statistics were computed for all data. The associations between variables were tested and multivariate analysis was done to adjust for all the possible characteristics that predict early EOC recurrence. RESULTS: the rate of recurrence of EOC was 76.4%. Suboptimal debulking surgery is the only independent predictor of early tumour recurrence. CONCLUSION: women should be adequately counselled and encouraged to report their symptoms early to ensure optimal primary treatment. Strategic efforts should also be made to further improve subspecialty training programs and skills development in gynaecological oncology in Nigeria and sub-Saharan Africa. https://www.panafrican-med-journal.com/content/article/36/272/pdf/272.pdf cytoreductionepithelial ovarian cancerfigo stagerecurrencelagos |
| spellingShingle | Kehinde Sharafadeen Okunade Imoleayo Elijah Adetuyi Muisi Adenekan Ephraim Ohazurike Rose Ihuoma Anorlu Risk predictors of early recurrence in women with epithelial ovarian cancer in Lagos, Nigeria The Pan African Medical Journal cytoreduction epithelial ovarian cancer figo stage recurrence lagos |
| title | Risk predictors of early recurrence in women with epithelial ovarian cancer in Lagos, Nigeria |
| title_full | Risk predictors of early recurrence in women with epithelial ovarian cancer in Lagos, Nigeria |
| title_fullStr | Risk predictors of early recurrence in women with epithelial ovarian cancer in Lagos, Nigeria |
| title_full_unstemmed | Risk predictors of early recurrence in women with epithelial ovarian cancer in Lagos, Nigeria |
| title_short | Risk predictors of early recurrence in women with epithelial ovarian cancer in Lagos, Nigeria |
| title_sort | risk predictors of early recurrence in women with epithelial ovarian cancer in lagos nigeria |
| topic | cytoreduction epithelial ovarian cancer figo stage recurrence lagos |
| url |
https://www.panafrican-med-journal.com/content/article/36/272/pdf/272.pdf
|
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