IAP antagonist GDC-0917 is more potent than Debio1143 in promoting cell death, c-IAP1 degradation and tumor growth inhibition
| Main Authors: | , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Publishing Group
2022-09-01
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| Series: | Cell Death and Disease |
| Online Access: | https://doi.org/10.1038/s41419-022-05283-w |
| _version_ | 1811201118802280448 |
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| author | Bruno Alicke Eugene Varfolomeev Shi Hui Kaylee Lee Alexandra Frommlet Savita Ubhayakar John G. Quinn Wayne J. Fairbrother Robert Jones Stephen E. Gould Domagoj Vucic |
| author_facet | Bruno Alicke Eugene Varfolomeev Shi Hui Kaylee Lee Alexandra Frommlet Savita Ubhayakar John G. Quinn Wayne J. Fairbrother Robert Jones Stephen E. Gould Domagoj Vucic |
| author_sort | Bruno Alicke |
| collection | DOAJ |
| first_indexed | 2024-04-12T02:15:31Z |
| format | Article |
| id | doaj.art-3db51e3eb06e462e8120746067b1af78 |
| institution | Directory Open Access Journal |
| issn | 2041-4889 |
| language | English |
| last_indexed | 2024-04-12T02:15:31Z |
| publishDate | 2022-09-01 |
| publisher | Nature Publishing Group |
| record_format | Article |
| series | Cell Death and Disease |
| spelling | doaj.art-3db51e3eb06e462e8120746067b1af782022-12-22T03:52:15ZengNature Publishing GroupCell Death and Disease2041-48892022-09-011391310.1038/s41419-022-05283-wIAP antagonist GDC-0917 is more potent than Debio1143 in promoting cell death, c-IAP1 degradation and tumor growth inhibitionBruno Alicke0Eugene Varfolomeev1Shi Hui Kaylee Lee2Alexandra Frommlet3Savita Ubhayakar4John G. Quinn5Wayne J. Fairbrother6Robert Jones7Stephen E. Gould8Domagoj Vucic9Departments of In Vivo Pharmacology, GenentechImmunology Discovery, GenentechDrug Metabolism and Pharmacokinetics, GenentechBiochemical and Cellular Pharmacology, GenentechDrug Metabolism and Pharmacokinetics, GenentechBiochemical and Cellular Pharmacology, GenentechEarly Discovery Biochemistry, GenentechDrug Metabolism and Pharmacokinetics, GenentechDepartments of In Vivo Pharmacology, GenentechImmunology Discovery, Genentechhttps://doi.org/10.1038/s41419-022-05283-w |
| spellingShingle | Bruno Alicke Eugene Varfolomeev Shi Hui Kaylee Lee Alexandra Frommlet Savita Ubhayakar John G. Quinn Wayne J. Fairbrother Robert Jones Stephen E. Gould Domagoj Vucic IAP antagonist GDC-0917 is more potent than Debio1143 in promoting cell death, c-IAP1 degradation and tumor growth inhibition Cell Death and Disease |
| title | IAP antagonist GDC-0917 is more potent than Debio1143 in promoting cell death, c-IAP1 degradation and tumor growth inhibition |
| title_full | IAP antagonist GDC-0917 is more potent than Debio1143 in promoting cell death, c-IAP1 degradation and tumor growth inhibition |
| title_fullStr | IAP antagonist GDC-0917 is more potent than Debio1143 in promoting cell death, c-IAP1 degradation and tumor growth inhibition |
| title_full_unstemmed | IAP antagonist GDC-0917 is more potent than Debio1143 in promoting cell death, c-IAP1 degradation and tumor growth inhibition |
| title_short | IAP antagonist GDC-0917 is more potent than Debio1143 in promoting cell death, c-IAP1 degradation and tumor growth inhibition |
| title_sort | iap antagonist gdc 0917 is more potent than debio1143 in promoting cell death c iap1 degradation and tumor growth inhibition |
| url | https://doi.org/10.1038/s41419-022-05283-w |
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