11β-HSD1 inhibition does not affect murine tumour angiogenesis but may exert a selective effect on tumour growth by modulating inflammation and fibrosis

11β-HSD1 inhibition does not affect murine tumour angiogenesis but may exert a selective effect on tumour growth by modulating inflammation and fibrosis

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Glucocorticoids inhibit angiogenesis by activating the glucocorticoid receptor. Inhibition of the glucocorticoid-activating enzyme 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1) reduces tissue-specific glucocorticoid action and promotes angiogenesis in murine models of myocardial infarction. Ang...

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Bibliographic Details
Main Authors: Callam T. Davidson, Eileen Miller, Morwenna Muir, John C. Dawson, Martin Lee, Stuart Aitken, Alan Serrels, Scott P. Webster, Natalie Z. M. Homer, Ruth Andrew, Valerie G. Brunton, Patrick W. F. Hadoke, Brian R. Walker
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2023-01-01
Series:PLoS ONE
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10027213/?tool=EBI

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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10027213/?tool=EBI

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