Prognostic value of hyperuricemia for patients with sepsis in the intensive care unit
Abstract This study evaluated the relationship between hyperuricemia at admission and the clinical prognosis of patients with sepsis. The data were obtained from the Intensive Care Medical Information Database III. The patients were divided into a normal serum uric acid group and a hyperuricemia gro...
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2022-01-01
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| Series: | Scientific Reports |
| Online Access: | https://doi.org/10.1038/s41598-022-04862-3 |
| _version_ | 1819260970052091904 |
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| author | Shizhen Liu Zhihua Zhong Fanna Liu |
| author_facet | Shizhen Liu Zhihua Zhong Fanna Liu |
| author_sort | Shizhen Liu |
| collection | DOAJ |
| description | Abstract This study evaluated the relationship between hyperuricemia at admission and the clinical prognosis of patients with sepsis. The data were obtained from the Intensive Care Medical Information Database III. The patients were divided into a normal serum uric acid group and a hyperuricemia group. The main outcome was 90-day mortality, and the secondary outcomes were hospital mortality, 30-day mortality, and acute kidney injury. Propensity score matching was used to balance the baseline characteristics of the groups. Our study retrospectively included 954 patients. Before and after propensity score matching, the incidence of AKI, the 30-day and 90-day mortality rates were significantly higher in the hyperuricemia group. Cox regression analysis showed that hyperuricemia was significantly associated with 90-day mortality (HR 1.648, 95% CI 1.215–2.234, p = 0.006), and hyperuricemia was significantly associated with the incidence of AKI (HR 1.773, 95% CI 1.107–2.841, p = 0.017). The Kaplan–Meier survival curve showed that the 90-day survival rate was significantly lower in the hyperuricemia group. In patients with sepsis in the intensive care unit, hyperuricemia was significantly associated with increased risk 90-day all-cause mortality and the incidence of AKI. |
| first_indexed | 2024-12-23T19:34:21Z |
| format | Article |
| id | doaj.art-3db624ad73704589b032fe0903f918d0 |
| institution | Directory Open Access Journal |
| issn | 2045-2322 |
| language | English |
| last_indexed | 2024-12-23T19:34:21Z |
| publishDate | 2022-01-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Scientific Reports |
| spelling | doaj.art-3db624ad73704589b032fe0903f918d02022-12-21T17:33:50ZengNature PortfolioScientific Reports2045-23222022-01-0112111010.1038/s41598-022-04862-3Prognostic value of hyperuricemia for patients with sepsis in the intensive care unitShizhen Liu0Zhihua Zhong1Fanna Liu2Department of Nephrology, The First Affiliated Hospital of Jinan UniversityCollege of Information Science and Technology, Jinan UniversityDepartment of Nephrology, The First Affiliated Hospital of Jinan UniversityAbstract This study evaluated the relationship between hyperuricemia at admission and the clinical prognosis of patients with sepsis. The data were obtained from the Intensive Care Medical Information Database III. The patients were divided into a normal serum uric acid group and a hyperuricemia group. The main outcome was 90-day mortality, and the secondary outcomes were hospital mortality, 30-day mortality, and acute kidney injury. Propensity score matching was used to balance the baseline characteristics of the groups. Our study retrospectively included 954 patients. Before and after propensity score matching, the incidence of AKI, the 30-day and 90-day mortality rates were significantly higher in the hyperuricemia group. Cox regression analysis showed that hyperuricemia was significantly associated with 90-day mortality (HR 1.648, 95% CI 1.215–2.234, p = 0.006), and hyperuricemia was significantly associated with the incidence of AKI (HR 1.773, 95% CI 1.107–2.841, p = 0.017). The Kaplan–Meier survival curve showed that the 90-day survival rate was significantly lower in the hyperuricemia group. In patients with sepsis in the intensive care unit, hyperuricemia was significantly associated with increased risk 90-day all-cause mortality and the incidence of AKI.https://doi.org/10.1038/s41598-022-04862-3 |
| spellingShingle | Shizhen Liu Zhihua Zhong Fanna Liu Prognostic value of hyperuricemia for patients with sepsis in the intensive care unit Scientific Reports |
| title | Prognostic value of hyperuricemia for patients with sepsis in the intensive care unit |
| title_full | Prognostic value of hyperuricemia for patients with sepsis in the intensive care unit |
| title_fullStr | Prognostic value of hyperuricemia for patients with sepsis in the intensive care unit |
| title_full_unstemmed | Prognostic value of hyperuricemia for patients with sepsis in the intensive care unit |
| title_short | Prognostic value of hyperuricemia for patients with sepsis in the intensive care unit |
| title_sort | prognostic value of hyperuricemia for patients with sepsis in the intensive care unit |
| url | https://doi.org/10.1038/s41598-022-04862-3 |
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