A Novel Class of Small Molecule Compounds that Inhibit Hepatitis C Virus Infection by Targeting the Prohibitin-CRaf Pathway

A Novel Class of Small Molecule Compounds that Inhibit Hepatitis C Virus Infection by Targeting the Prohibitin-CRaf Pathway

Identification of novel drug targets and affordable therapeutic agents remains a high priority in the fight against chronic hepatitis C virus (HCV) infection. Here, we report that the cellular proteins prohibitin 1 (PHB1) and 2 (PHB2) are pan-genotypic HCV entry factors functioning at a post-binding...

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Bibliographic Details
Main Authors: Shufeng Liu, Wenyu Wang, Lauren E. Brown, Chao Qiu, Neil Lajkiewicz, Ting Zhao, Jianhua Zhou, John A. Porco Jr, Tony T. Wang
Format: Article
Language:English
Published: Elsevier 2015-11-01
Series:EBioMedicine
Subjects:
HCV
Entry factors
Entry inhibitors
Rocaglates
Online Access:http://www.sciencedirect.com/science/article/pii/S2352396415301377

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