The Effects of WW2/WW3 Domains of Smurf2 Molecule on CD4+CD25+/CD4+ Proportion in Spleen of 4T1 Tumor Bearing BALB/c Mice

The Effects of WW2/WW3 Domains of Smurf2 Molecule on CD4+CD25+/CD4+ Proportion in Spleen of 4T1 Tumor Bearing BALB/c Mice

Background: TGF-β has long been considered as the main inducer of Tregs in tumor microenvironment and is the reason for the aberrant number of Tregs in tumor-bearing individuals. Recently, it has been suggested that the enzyme arginase I is able to mediate the induction of Tregs in a TGF-β-independe...

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Bibliographic Details
Main Authors: Hani Mosayebzadeh Roshan, Seyed-Hosein Abtahi-Eivary, Hassan Shojaee-Mend, Alireza Mohammadzadeh, Zahra Bahari Sani
Format: Article
Language:English
Published: Pasteur Institute of Iran 2020-07-01
Series:Iranian Biomedical Journal
Subjects:
arginase
transforming growth factor-ꞵ
ww domains
Online Access:http://ibj.pasteur.ac.ir/article-1-3041-en.html

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