Congenital Tufting Enteropathy-Associated Mutant of Epithelial Cell Adhesion Molecule Activates the Unfolded Protein Response in a Murine Model of the Disease

Congenital Tufting Enteropathy-Associated Mutant of Epithelial Cell Adhesion Molecule Activates the Unfolded Protein Response in a Murine Model of the Disease

Congenital tufting enteropathy (CTE) is a rare chronic diarrheal disease of infancy caused by mutations in epithelial cell adhesion molecule (EpCAM). Previously, a murine CTE model showed mis-localization of EpCAM away from the basolateral cell surface in the intestine. Here we demonstrate that muta...

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Bibliographic Details
Main Authors: Barun Das, Kevin Okamoto, John Rabalais, Ronald R. Marchelletta, Kim E. Barrett, Soumita Das, Maho Niwa, Mamata Sivagnanam
Format: Article
Language:English
Published: MDPI AG 2020-04-01
Series:Cells
Subjects:
congenital tufting enteropathy
mutant EpCAM
ER stress
unfolded protein response
Online Access:https://www.mdpi.com/2073-4409/9/4/946

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