The future of cell-instructive biomaterials for tissue regeneration–a perspective from early career clinician-scientists
Cell-instructive biomaterials are an essential component in tissue engineering and regenerative medicine. In the past three decades since the term “Tissue Engineering” was coined, researchers have made significant progress towards regenerating disease or damage tissues and organs by combining innova...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2024-01-01
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| Series: | Frontiers in Materials |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fmats.2023.1328904/full |
| _version_ | 1827381153764474880 |
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| author | Rodrigo Rangel W. Benton Swanson David T. Wu David T. Wu David T. Wu |
| author_facet | Rodrigo Rangel W. Benton Swanson David T. Wu David T. Wu David T. Wu |
| author_sort | Rodrigo Rangel |
| collection | DOAJ |
| description | Cell-instructive biomaterials are an essential component in tissue engineering and regenerative medicine. In the past three decades since the term “Tissue Engineering” was coined, researchers have made significant progress towards regenerating disease or damage tissues and organs by combining innovations in biomaterials, signaling molecules and cell therapies. However, challenges persist including limitations in properties of cell-instructive biomaterials, lack of advanced manufacturing technologies for precise spatiotemporal control of key players in tissue engineering, and hurdles in clinical translation and regulatory process. In this perspective article, we briefly review the current state of the field including the evolution in our understanding of the role biomaterial mechanics and scaffolding architecture, development of self-healing and modular biomaterials, and progress in advanced manufacturing technologies such as 3D bioprinting. In addition, we discuss about how innovation in research technologies including multi-omics and spatial biology, and advanced imaging modalities may pave the way for enhancing our understanding about cell-biomaterial interactions. Finally, we present our perspective as early career clinicians and researchers on the key role and potential impact that clinician-scientists can generate in the development, validation, clinical translation and adoption of the next-generation of cell-instructive biomaterials for application in engineering tissues and organs to impact human health. |
| first_indexed | 2024-03-08T13:50:07Z |
| format | Article |
| id | doaj.art-3dbb2a7e1a574abb9949454f03530def |
| institution | Directory Open Access Journal |
| issn | 2296-8016 |
| language | English |
| last_indexed | 2024-03-08T13:50:07Z |
| publishDate | 2024-01-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Materials |
| spelling | doaj.art-3dbb2a7e1a574abb9949454f03530def2024-01-16T04:11:47ZengFrontiers Media S.A.Frontiers in Materials2296-80162024-01-011010.3389/fmats.2023.13289041328904The future of cell-instructive biomaterials for tissue regeneration–a perspective from early career clinician-scientistsRodrigo Rangel0W. Benton Swanson1David T. Wu2David T. Wu3David T. Wu4Department of Oral Medicine, Infection, and Immunity, Harvard School of Dental Medicine, Boston, MA, United StatesDepartment of Biologic and Materials Science, University of Michigan School of Dentistry, Ann Arbor, MI, United StatesDepartment of Oral Medicine, Infection, and Immunity, Harvard School of Dental Medicine, Boston, MA, United StatesDepartment of Biologic and Materials Science, University of Michigan School of Dentistry, Ann Arbor, MI, United StatesJohn A. Paulson School of Engineering and Applied Sciences, Harvard University, Cambridge, MA, United StatesCell-instructive biomaterials are an essential component in tissue engineering and regenerative medicine. In the past three decades since the term “Tissue Engineering” was coined, researchers have made significant progress towards regenerating disease or damage tissues and organs by combining innovations in biomaterials, signaling molecules and cell therapies. However, challenges persist including limitations in properties of cell-instructive biomaterials, lack of advanced manufacturing technologies for precise spatiotemporal control of key players in tissue engineering, and hurdles in clinical translation and regulatory process. In this perspective article, we briefly review the current state of the field including the evolution in our understanding of the role biomaterial mechanics and scaffolding architecture, development of self-healing and modular biomaterials, and progress in advanced manufacturing technologies such as 3D bioprinting. In addition, we discuss about how innovation in research technologies including multi-omics and spatial biology, and advanced imaging modalities may pave the way for enhancing our understanding about cell-biomaterial interactions. Finally, we present our perspective as early career clinicians and researchers on the key role and potential impact that clinician-scientists can generate in the development, validation, clinical translation and adoption of the next-generation of cell-instructive biomaterials for application in engineering tissues and organs to impact human health.https://www.frontiersin.org/articles/10.3389/fmats.2023.1328904/fullbiomaterialstissue engineeringmechanobiologymechanoregenerationscaffold architecture3D bioprinting |
| spellingShingle | Rodrigo Rangel W. Benton Swanson David T. Wu David T. Wu David T. Wu The future of cell-instructive biomaterials for tissue regeneration–a perspective from early career clinician-scientists Frontiers in Materials biomaterials tissue engineering mechanobiology mechanoregeneration scaffold architecture 3D bioprinting |
| title | The future of cell-instructive biomaterials for tissue regeneration–a perspective from early career clinician-scientists |
| title_full | The future of cell-instructive biomaterials for tissue regeneration–a perspective from early career clinician-scientists |
| title_fullStr | The future of cell-instructive biomaterials for tissue regeneration–a perspective from early career clinician-scientists |
| title_full_unstemmed | The future of cell-instructive biomaterials for tissue regeneration–a perspective from early career clinician-scientists |
| title_short | The future of cell-instructive biomaterials for tissue regeneration–a perspective from early career clinician-scientists |
| title_sort | future of cell instructive biomaterials for tissue regeneration a perspective from early career clinician scientists |
| topic | biomaterials tissue engineering mechanobiology mechanoregeneration scaffold architecture 3D bioprinting |
| url | https://www.frontiersin.org/articles/10.3389/fmats.2023.1328904/full |
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