Microbiome Shapes the T Cell Receptor Repertoire among CD4+CD8+ Thymocytes

Microbiome Shapes the T Cell Receptor Repertoire among CD4+CD8+ Thymocytes

The microbiome shapes the mature T cell receptor (TCR) repertoire and thereby influences pathogen control. To investigate microbiome influences on T cells at an earlier, immature stage, we compared single-cell TCR transcript sequences between CD4+CD8+ (double-positive) thymocytes from gnotobiotic [&...

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Bibliographic Details
Main Authors: Sherri L. Surman, Jeremy Crawford, Pradyot Dash, Susan L. Tonkonogy, Paul G. Thomas, Julia L. Hurwitz
Format: Article
Language:English
Published: MDPI AG 2022-11-01
Series:Biomedicines
Subjects:
<i>E. coli</i>
germ-free
gnotobiotic
T cell receptor repertoire
thymus
CD4+CD8+ T cell
Online Access:https://www.mdpi.com/2227-9059/10/12/3015

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