Efficacy of polyacrylate silver salt/polyvinylpyrrolidone-based liquid oral gel in management of concurrence chemoradiotherapy-induced oral mucositis
Background/Purpose: Acute oral mucositis (OM) is a painful complication of concurrent chemoradiotherapy (CCRT). This severe adverse symptom may impact on patient's quality of life, lead to malnutrition. Thus, finding more effective methods in OM management is very important. The purpose of this...
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| Format: | Article |
| Language: | English |
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Elsevier
2023-08-01
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| Series: | Journal of the Formosan Medical Association |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S0929664622004466 |
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| author | Hsiao-Lei Chin Kuo-Piao Chung Hsin-Cheng Liu Rung-Shu Chen Hao-Hueng Chang Min-Huey Chen |
| author_facet | Hsiao-Lei Chin Kuo-Piao Chung Hsin-Cheng Liu Rung-Shu Chen Hao-Hueng Chang Min-Huey Chen |
| author_sort | Hsiao-Lei Chin |
| collection | DOAJ |
| description | Background/Purpose: Acute oral mucositis (OM) is a painful complication of concurrent chemoradiotherapy (CCRT). This severe adverse symptom may impact on patient's quality of life, lead to malnutrition. Thus, finding more effective methods in OM management is very important. The purpose of this study is to evaluate the efficacy of polyacrylate silver salt/Polyvinylpyrrolidone-based liquid oral gel (named as polyacrylate silver salt oral gel) in improving the symptomatic relief of CCRT-induced oral mucositis and oral dysfunction in neck and head cancer patients. Methods: In this study, 24 oral cancer patients underwent CCRT and having OM grade 2 or higher were randomly assigned into the test group and the control group. Both groups followed Multinational Association of Supportive Care in Cancer and International Society of Oral Oncology (MASCC/ISOO) clinical practice guidelines for the management of mucositis, but adding rinsing with 15 g oral gel right after oral hygiene treaded the test group. Clinical OM and oral function were assessed weekly for 4 consecutive weeks till 5–10 days after the completion of radiotherapy. For evaluation, Common Terminology Criteria for Adverse Events (CTCAE) v3.0 was used for collecting the data of OM grade. Results: The results showed that polyacrylate silver salt oral gel had better effect for relieving the oral mucositis. There were statistically significant differences in OM grades (1.59 vs. 2.8, p < 0.0001) between the test group and the control group. Conclusion: Our clinical studies demonstrated that polyacrylate silver salt oral gel is an effective interventional option in terms of rapid mucositis healing. |
| first_indexed | 2024-03-12T23:38:34Z |
| format | Article |
| id | doaj.art-3dbd5d0c03cd4163b44ed06488895496 |
| institution | Directory Open Access Journal |
| issn | 0929-6646 |
| language | English |
| last_indexed | 2024-03-12T23:38:34Z |
| publishDate | 2023-08-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Journal of the Formosan Medical Association |
| spelling | doaj.art-3dbd5d0c03cd4163b44ed064888954962023-07-15T04:28:12ZengElsevierJournal of the Formosan Medical Association0929-66462023-08-011228723730Efficacy of polyacrylate silver salt/polyvinylpyrrolidone-based liquid oral gel in management of concurrence chemoradiotherapy-induced oral mucositisHsiao-Lei Chin0Kuo-Piao Chung1Hsin-Cheng Liu2Rung-Shu Chen3Hao-Hueng Chang4Min-Huey Chen5College of Public Health, National Taiwan University, TaiwanCollege of Public Health, National Taiwan University, TaiwanGraduate Institute of Clinical Dentistry, School of Dentistry, National Taiwan University, Taiwan; College of Management, National Yang Ming Chiao Tung University, TaiwanGraduate Institute of Clinical Dentistry, School of Dentistry, National Taiwan University, TaiwanDepartment of Dentistry, National Taiwan University Hospital, Taiwan; School of Dentistry, National Taiwan University, Taiwan; Corresponding author. Department of Dentistry, National Taiwan University Hospital, School of Dentistry, National Taiwan University, No.7, Chung-Shan South Road, Taipei, 100, Taiwan. Fax: +886 2 23224552.Graduate Institute of Clinical Dentistry, School of Dentistry, National Taiwan University, Taiwan; Department of Dentistry, National Taiwan University Hospital, Taiwan; Corresponding author. Graduate Institute of Clinical Dentistry, School of Dentistry, National Taiwan University, Department of Dentistry, National Taiwan University Hospital, No.7, Chung-Shan South Road, Taipei, 100, Taiwan.Background/Purpose: Acute oral mucositis (OM) is a painful complication of concurrent chemoradiotherapy (CCRT). This severe adverse symptom may impact on patient's quality of life, lead to malnutrition. Thus, finding more effective methods in OM management is very important. The purpose of this study is to evaluate the efficacy of polyacrylate silver salt/Polyvinylpyrrolidone-based liquid oral gel (named as polyacrylate silver salt oral gel) in improving the symptomatic relief of CCRT-induced oral mucositis and oral dysfunction in neck and head cancer patients. Methods: In this study, 24 oral cancer patients underwent CCRT and having OM grade 2 or higher were randomly assigned into the test group and the control group. Both groups followed Multinational Association of Supportive Care in Cancer and International Society of Oral Oncology (MASCC/ISOO) clinical practice guidelines for the management of mucositis, but adding rinsing with 15 g oral gel right after oral hygiene treaded the test group. Clinical OM and oral function were assessed weekly for 4 consecutive weeks till 5–10 days after the completion of radiotherapy. For evaluation, Common Terminology Criteria for Adverse Events (CTCAE) v3.0 was used for collecting the data of OM grade. Results: The results showed that polyacrylate silver salt oral gel had better effect for relieving the oral mucositis. There were statistically significant differences in OM grades (1.59 vs. 2.8, p < 0.0001) between the test group and the control group. Conclusion: Our clinical studies demonstrated that polyacrylate silver salt oral gel is an effective interventional option in terms of rapid mucositis healing.http://www.sciencedirect.com/science/article/pii/S0929664622004466ChemoradiotherapyNeck and head cancerPolyacrylate silver saltOral gelOral mucositis |
| spellingShingle | Hsiao-Lei Chin Kuo-Piao Chung Hsin-Cheng Liu Rung-Shu Chen Hao-Hueng Chang Min-Huey Chen Efficacy of polyacrylate silver salt/polyvinylpyrrolidone-based liquid oral gel in management of concurrence chemoradiotherapy-induced oral mucositis Journal of the Formosan Medical Association Chemoradiotherapy Neck and head cancer Polyacrylate silver salt Oral gel Oral mucositis |
| title | Efficacy of polyacrylate silver salt/polyvinylpyrrolidone-based liquid oral gel in management of concurrence chemoradiotherapy-induced oral mucositis |
| title_full | Efficacy of polyacrylate silver salt/polyvinylpyrrolidone-based liquid oral gel in management of concurrence chemoradiotherapy-induced oral mucositis |
| title_fullStr | Efficacy of polyacrylate silver salt/polyvinylpyrrolidone-based liquid oral gel in management of concurrence chemoradiotherapy-induced oral mucositis |
| title_full_unstemmed | Efficacy of polyacrylate silver salt/polyvinylpyrrolidone-based liquid oral gel in management of concurrence chemoradiotherapy-induced oral mucositis |
| title_short | Efficacy of polyacrylate silver salt/polyvinylpyrrolidone-based liquid oral gel in management of concurrence chemoradiotherapy-induced oral mucositis |
| title_sort | efficacy of polyacrylate silver salt polyvinylpyrrolidone based liquid oral gel in management of concurrence chemoradiotherapy induced oral mucositis |
| topic | Chemoradiotherapy Neck and head cancer Polyacrylate silver salt Oral gel Oral mucositis |
| url | http://www.sciencedirect.com/science/article/pii/S0929664622004466 |
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