EPHB4-RASA1-Mediated Negative Regulation of Ras-MAPK Signaling in the Vasculature: Implications for the Treatment of EPHB4- and RASA1-Related Vascular Anomalies in Humans

EPHB4-RASA1-Mediated Negative Regulation of Ras-MAPK Signaling in the Vasculature: Implications for the Treatment of EPHB4- and RASA1-Related Vascular Anomalies in Humans

Ephrin receptors constitute a large family of receptor tyrosine kinases in mammals that through interaction with cell surface-anchored ephrin ligands regulate multiple different cellular responses in numerous cell types and tissues. In the cardiovascular system, studies performed in vitro and in viv...

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Bibliographic Details
Main Authors: Di Chen, Martijn A. Van der Ent, Nathaniel L. Lartey, Philip D. King
Format: Article
Language:English
Published: MDPI AG 2023-01-01
Series:Pharmaceuticals
Subjects:
Ephrin receptor B4
RASA1
Ras-MAPK pathway
capillary malformation arteriovenous malformation
lymphatic malformation
angiogenesis
Online Access:https://www.mdpi.com/1424-8247/16/2/165

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