Hotspots in basic and translational research of gastric cancer
The morbidity and mortality of gastric cancer are high, while the overall therapeutic effect is poor without satisfactory. Clinical obstacles, such as low early-diagnosis rate, tumor heterogeneity, lack of accurate classification and precise treatment, therapeutic resistance, recurrence and metastas...
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| Format: | Article |
| Language: | zho |
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Editorial Office of Journal of Surgery Concepts & Practice
2023-01-01
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| Series: | Waike lilun yu shijian |
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| Online Access: | https://www.qk.sjtu.edu.cn/jscp/fileup/1007-9610/PDF/1679721897460-1605677392.pdf |
| _version_ | 1797648493195558912 |
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| author | LI Jianfang, YU Junxian, YAN Chao, ZHU Zhenggang, LIU Bingya |
| author_facet | LI Jianfang, YU Junxian, YAN Chao, ZHU Zhenggang, LIU Bingya |
| author_sort | LI Jianfang, YU Junxian, YAN Chao, ZHU Zhenggang, LIU Bingya |
| collection | DOAJ |
| description | The morbidity and mortality of gastric cancer are high, while the overall therapeutic effect is poor without satisfactory. Clinical obstacles, such as low early-diagnosis rate, tumor heterogeneity, lack of accurate classification and precise treatment, therapeutic resistance, recurrence and metastasis, are the key point issues to the lower efficacy in treatment of gastric cancer. In order to solve these clinical problems, it is necessary to devote more energy to the basic research of gastric cancer, including tumor genomics; gene editing; tumor microenvironment; inflammation, aging and tumor; cell differentiation disorders; autophagy and cell death; metabolic disorders; immunotherapy and drug development. This paper will summarize the clinical obstacles in the treatment of gastric cancer, and describe the directions of basic research on these clinical problems in future, so as to provide notions for the translational research of gastric cancer. |
| first_indexed | 2024-03-11T15:31:57Z |
| format | Article |
| id | doaj.art-3dc0cf9545b0426fb292f1369f0d7dee |
| institution | Directory Open Access Journal |
| issn | 1007-9610 |
| language | zho |
| last_indexed | 2024-03-11T15:31:57Z |
| publishDate | 2023-01-01 |
| publisher | Editorial Office of Journal of Surgery Concepts & Practice |
| record_format | Article |
| series | Waike lilun yu shijian |
| spelling | doaj.art-3dc0cf9545b0426fb292f1369f0d7dee2023-10-27T02:14:23ZzhoEditorial Office of Journal of Surgery Concepts & PracticeWaike lilun yu shijian1007-96102023-01-01280171610.16139/j.1007-9610.2023.01.02Hotspots in basic and translational research of gastric cancerLI Jianfang, YU Junxian, YAN Chao, ZHU Zhenggang, LIU Bingya0Department of General Surgery, Shanghai Institute of Digestive Surgery, Shanghai Key Laboratory of Gastric Neoplasms, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, ChinaThe morbidity and mortality of gastric cancer are high, while the overall therapeutic effect is poor without satisfactory. Clinical obstacles, such as low early-diagnosis rate, tumor heterogeneity, lack of accurate classification and precise treatment, therapeutic resistance, recurrence and metastasis, are the key point issues to the lower efficacy in treatment of gastric cancer. In order to solve these clinical problems, it is necessary to devote more energy to the basic research of gastric cancer, including tumor genomics; gene editing; tumor microenvironment; inflammation, aging and tumor; cell differentiation disorders; autophagy and cell death; metabolic disorders; immunotherapy and drug development. This paper will summarize the clinical obstacles in the treatment of gastric cancer, and describe the directions of basic research on these clinical problems in future, so as to provide notions for the translational research of gastric cancer.https://www.qk.sjtu.edu.cn/jscp/fileup/1007-9610/PDF/1679721897460-1605677392.pdf|gastric cancer|translational medicine|genomics|immunotherapy |
| spellingShingle | LI Jianfang, YU Junxian, YAN Chao, ZHU Zhenggang, LIU Bingya Hotspots in basic and translational research of gastric cancer Waike lilun yu shijian |gastric cancer|translational medicine|genomics|immunotherapy |
| title | Hotspots in basic and translational research of gastric cancer |
| title_full | Hotspots in basic and translational research of gastric cancer |
| title_fullStr | Hotspots in basic and translational research of gastric cancer |
| title_full_unstemmed | Hotspots in basic and translational research of gastric cancer |
| title_short | Hotspots in basic and translational research of gastric cancer |
| title_sort | hotspots in basic and translational research of gastric cancer |
| topic | |gastric cancer|translational medicine|genomics|immunotherapy |
| url | https://www.qk.sjtu.edu.cn/jscp/fileup/1007-9610/PDF/1679721897460-1605677392.pdf |
| work_keys_str_mv | AT lijianfangyujunxianyanchaozhuzhenggangliubingya hotspotsinbasicandtranslationalresearchofgastriccancer |