The dimerization of Δ9-tetrahydrocannabinolic acid A (THCA-A)

The dimerization of Δ9-tetrahydrocannabinolic acid A (THCA-A)

The renewed interest in dimeric salicylates as broad-spectrum anti-inflammatory and anti-diabetic agents provided a rationale to investigate the dimerization of the substituted salicylate Δ9-tetrahydrocannabinolic acid (THCA-A, 3a) as a strategy to solve its instability to decarboxylation and to gen...

Full description

Bibliographic Details
Main Authors:	Arben Cuadari, Federica Pollastro, Juan D. Unciti-Broceta, Diego Caprioglio, Alberto Minassi, Annalisa Lopatriello, Eduardo Muñoz, Orazio Taglialatela-Scafati, Giovanni Appendino
Format:	Article
Language:	English
Published:	Elsevier 2019-09-01
Series:	Acta Pharmaceutica Sinica B
Online Access:	http://www.sciencedirect.com/science/article/pii/S221138351930379X

Similar Items

Cannabinoquinones: Synthesis and Biological Profile
by: Diego Caprioglio, et al.
Published: (2021-07-01)

Minor Phytocannabinoids: A Misleading Name but a Promising Opportunity for Biomedical Research
by: Diego Caprioglio, et al.
Published: (2022-08-01)

Biomimetic Approaches to the Synthesis of Natural Disesquiterpenoids: An Update
by: Diego Caprioglio, et al.
Published: (2021-04-01)

The Combined Effect of Branching and Elongation on the Bioactivity Profile of Phytocannabinoids. Part I: Thermo-TRPs
by: Daiana Mattoteia, et al.
Published: (2021-08-01)

Toxicological properties of Δ9-tetrahydrocannabinol and cannabidiol
by: Černe Katarina
Published: (2020-03-01)

New Hopes for Drugs against COVID-19 Come from the Sea
by: Orazio Taglialatela-Scafati
Published: (2021-02-01)

Editor-in-Chief’s Letter to Readers and Authors of <i>Marine Drugs</i>
by: Orazio Taglialatela-Scafati
Published: (2021-07-01)

Exploring the Universe of Natural Products: Recent Advances in Synthesis, Isolation and Structural Elucidation
by: Federica Pollastro, et al.
Published: (2021-11-01)

Δ9-tetrahydrocannabinol discrimination: Effects of route of administration in mice
by: Julie A. Marusich, et al.
Published: (2023-12-01)

Acute human exposure assessment to tetrahydrocannabinol (Δ9‐THC)
by: European Food Safety Authority (EFSA), et al.
Published: (2020-01-01)

Modern alkaloids : structure, isolation, synthesis and biology /
by: Fattorusso, Ernesto, et al.
Published: (2008)

Marine Antimalarials
by: Orazio Taglialatela-Scafati, et al.
Published: (2009-04-01)

Comparative Metabolomic Profiling of the Metabolic Differences of Δ9-Tetrahydrocannabinol and Cannabidiol
by: Qianru Rao, et al.
Published: (2022-11-01)

Tolerance and dependence to Δ9-tetrahydrocannabinol in rhesus monkeys: Activity assessments.
by: Jenny L Wilkerson, et al.
Published: (2019-01-01)

Detection of Δ9-tetrahydrocannabinol (THC) in hair using GC–MS
by: Himanshu Khajuria, et al.
Published: (2014-03-01)

Δ<sup>8</sup>-THC Induces Up-Regulation of Glutamatergic Pathway Genes in Differentiated SH-SY5Y: A Transcriptomic Study
by: Ivan Anchesi, et al.
Published: (2023-05-01)

Δ<sup>8</sup>-THC Protects against Amyloid Beta Toxicity Modulating ER Stress In Vitro: A Transcriptomic Analysis
by: Agnese Gugliandolo, et al.
Published: (2023-04-01)

Hydroxylation and glycosylation of Δ9-tetrahydrocannabinol by Catharanthus roseus cell suspension culture
by: Akhtar, Muhammad Tayyab, et al.
Published: (2015)

Disease-modifying effects of natural Δ9-tetrahydrocannabinol in endometriosis-associated pain
by: Alejandra Escudero-Lara, et al.
Published: (2020-01-01)

Cannabis Use and Neuroadaptation: A Call for Δ9-Tetrahydrocannabinol Challenge Studies
by: Johannes G. Ramaekers, et al.
Published: (2022-04-01)

Adverse effects of Δ9-tetrahydrocannabinol on neuronal bioenergetics during postnatal development
by: Johannes Beiersdorf, et al.
Published: (2020-12-01)

A One-Step Grafting Methodology Can Adjust Stem Morphology and Increase THCA Yield in Medicinal Cannabis
by: Sarah Jane Purdy, et al.
Published: (2022-03-01)

The potential of natural products for targeting PPARα
by: Daniela Rigano, et al.
Published: (2017-07-01)

Manipulating brain connectivity with δ⁹-tetrahydrocannabinol: a pharmacological resting state FMRI study.
by: Klumpers, L, et al.
Published: (2012)

Neuronal and Astrocytic Morphological Alterations Driven by Prolonged Exposure with Δ9-Tetrahydrocannabinol but Not Cannabidiol
by: Elisa Landucci, et al.
Published: (2022-01-01)

Oral Administration of Cannabis and Δ-9-tetrahydrocannabinol (THC) Preparations: A Systematic Review
by: Lourdes Poyatos, et al.
Published: (2020-06-01)

Screening microbially produced Δ9-tetrahydrocannabinol using a yeast biosensor workflow
by: William M. Shaw, et al.
Published: (2022-09-01)

Anticancer activity of Δ9-tetrahydrocannabinol and cannabinol in vitro and in human lung cancer xenograft
by: Surang Leelawat, et al.
Published: (2022-01-01)

A Systematic Review and Meta-Analysis of the In Vivo Haemodynamic Effects of Δ9-Tetrahydrocannabinol
by: Salahaden R. Sultan, et al.
Published: (2018-01-01)

Single and Synergistic Effects of Cannabidiol and Δ-9-Tetrahydrocannabinol on Zebrafish Models of Neuro-Hyperactivity
by: Éric Samarut, et al.
Published: (2019-03-01)

Δ9-Tetrahydrocannabinol content in cannabis samples seized in Novi Sad during 2008
by: MAJA DJURENDIĆ-BRENESEL, et al.
Published: (2010-07-01)

Default mode network in the effects of Δ9-Tetrahydrocannabinol (THC) on human executive function.
by: Matthijs G Bossong, et al.
Published: (2013-01-01)

Optimal condition of cannabis maceration to obtain the high cannabidiol and Δ9-tetrahydrocannabinol content
by: CHAOWALIT MONTON, et al.
Published: (2019-10-01)

Pharmacokinetics of Cannabidiol, Cannabidiolic Acid, Δ9-Tetrahydrocannabinol, Tetrahydrocannabinolic Acid and Related Metabolites in Canine Serum After Dosing With Three Oral Forms of Hemp Extract
by: Joseph J. Wakshlag, et al.
Published: (2020-09-01)

Development of a plant-produced recombinant monoclonal antibody against Δ-9-tetrahydrocannabinol (Δ9-THC) for immunoassay application
by: Wanuttha Boonyayothin, et al.
Published: (2022-06-01)

The Cannabinoids, CBDA and THCA, Rescue Memory Deficits and Reduce Amyloid-Beta and Tau Pathology in an Alzheimer’s Disease-like Mouse Model
by: Juyong Kim, et al.
Published: (2023-04-01)

Antidepressant-like effects of Δ9-tetrahydrocannabinol and rimonabant in the olfactory bulbectomised rat model of depression
by: Mohamed Elbatsh, Maha, et al.
Published: (2012)

The Effect of Orally Administered Δ9-Tetrahydrocannabinol (THC) and Cannabidiol (CBD) on Obesity Parameters in Mice
by: Adi Eitan, et al.
Published: (2023-09-01)

Combinations of Cannabidiol and Δ<sup>9</sup>-Tetrahydrocannabinol in Reducing Chemotherapeutic Induced Neuropathic Pain
by: Diana E. Sepulveda, et al.
Published: (2022-10-01)

Enrichment and identification of Δ9-Tetrahydrocannabinolic acid synthase from Pichia pastoris culture supernatants
by: Kerstin Lange, et al.
Published: (2015-09-01)