Research progress of aconitine toxicity and forensic analysis of aconitine poisoning
Chinese herbal medicines have been extensively used in China and other countries for centuries. Aconitine, a diterpenoid alkaloid extracted from Aconitum plants, has anti-inflammatory and analgesic activities, but can also induce severe arrhythmia and neurotoxicity. Aconitine poisoning accidents cau...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Oxford University Press
2020-01-01
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| Series: | Forensic Sciences Research |
| Subjects: | |
| Online Access: | http://dx.doi.org/10.1080/20961790.2018.1452346 |
| _version_ | 1827883966769659904 |
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| author | Xiangting Gao Jun Hu Xincai Zhang Yuanyi Zuo Yun Wang Shaohua Zhu |
| author_facet | Xiangting Gao Jun Hu Xincai Zhang Yuanyi Zuo Yun Wang Shaohua Zhu |
| author_sort | Xiangting Gao |
| collection | DOAJ |
| description | Chinese herbal medicines have been extensively used in China and other countries for centuries. Aconitine, a diterpenoid alkaloid extracted from Aconitum plants, has anti-inflammatory and analgesic activities, but can also induce severe arrhythmia and neurotoxicity. Aconitine poisoning accidents caused by misuse, suicide, or homicide have been reported in recent years. In China, fatal aconitine poisoning can occasionally happen on account of accidental ingestion of some wild plants or consumption of herbal decoction made from the roots of Aconitum plants. However, it is rather difficult for forensic experts to find the specific results in present forensic autopsy of aconitine-induced death. To further clarify its potential risk following the widespread application of aconitine, toxicological characteristics and pharmacokinetics of aconitine are reviewed. Moreover, gastrointestinal, neurological, and cardiovascular symptoms were observed frequently in aconitine poisoning cases. In addition, the review also aims at providing some convincing evidences for forensic experts to identify unexplained death with postmortem examination. |
| first_indexed | 2024-03-12T19:20:44Z |
| format | Article |
| id | doaj.art-3dc5cd6fdebb470694c858071db1d016 |
| institution | Directory Open Access Journal |
| issn | 2096-1790 2471-1411 |
| language | English |
| last_indexed | 2024-03-12T19:20:44Z |
| publishDate | 2020-01-01 |
| publisher | Oxford University Press |
| record_format | Article |
| series | Forensic Sciences Research |
| spelling | doaj.art-3dc5cd6fdebb470694c858071db1d0162023-08-02T05:12:21ZengOxford University PressForensic Sciences Research2096-17902471-14112020-01-0151253110.1080/20961790.2018.14523461452346Research progress of aconitine toxicity and forensic analysis of aconitine poisoningXiangting Gao0Jun Hu1Xincai Zhang2Yuanyi Zuo3Yun Wang4Shaohua Zhu5Soochow UniversitySoochow UniversitySoochow UniversitySoochow UniversitySoochow UniversitySoochow UniversityChinese herbal medicines have been extensively used in China and other countries for centuries. Aconitine, a diterpenoid alkaloid extracted from Aconitum plants, has anti-inflammatory and analgesic activities, but can also induce severe arrhythmia and neurotoxicity. Aconitine poisoning accidents caused by misuse, suicide, or homicide have been reported in recent years. In China, fatal aconitine poisoning can occasionally happen on account of accidental ingestion of some wild plants or consumption of herbal decoction made from the roots of Aconitum plants. However, it is rather difficult for forensic experts to find the specific results in present forensic autopsy of aconitine-induced death. To further clarify its potential risk following the widespread application of aconitine, toxicological characteristics and pharmacokinetics of aconitine are reviewed. Moreover, gastrointestinal, neurological, and cardiovascular symptoms were observed frequently in aconitine poisoning cases. In addition, the review also aims at providing some convincing evidences for forensic experts to identify unexplained death with postmortem examination.http://dx.doi.org/10.1080/20961790.2018.1452346forensic sciencesaconitinetoxic effectsmetabolic characteristics |
| spellingShingle | Xiangting Gao Jun Hu Xincai Zhang Yuanyi Zuo Yun Wang Shaohua Zhu Research progress of aconitine toxicity and forensic analysis of aconitine poisoning Forensic Sciences Research forensic sciences aconitine toxic effects metabolic characteristics |
| title | Research progress of aconitine toxicity and forensic analysis of aconitine poisoning |
| title_full | Research progress of aconitine toxicity and forensic analysis of aconitine poisoning |
| title_fullStr | Research progress of aconitine toxicity and forensic analysis of aconitine poisoning |
| title_full_unstemmed | Research progress of aconitine toxicity and forensic analysis of aconitine poisoning |
| title_short | Research progress of aconitine toxicity and forensic analysis of aconitine poisoning |
| title_sort | research progress of aconitine toxicity and forensic analysis of aconitine poisoning |
| topic | forensic sciences aconitine toxic effects metabolic characteristics |
| url | http://dx.doi.org/10.1080/20961790.2018.1452346 |
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