Hippo signaling pathway in companion animal diseases, an under investigated signaling cascade
The Hippo pathway is a highly conserved kinase cascade in mammals with the proteins YAP and TAZ as its most important downstream effectors that shuttle between cytoplasma and nucleus. It has a crucial role in processes such as embryogenesis, organ size control, homeostasis and tissue regeneration, w...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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Taylor & Francis Group
2021-12-01
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| Series: | Veterinary Quarterly |
| Subjects: | |
| Online Access: | http://dx.doi.org/10.1080/01652176.2021.1923085 |
| _version_ | 1819319882041262080 |
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| author | Shaydee J. Budel Marloes M. Penning Louis C. Penning |
| author_facet | Shaydee J. Budel Marloes M. Penning Louis C. Penning |
| author_sort | Shaydee J. Budel |
| collection | DOAJ |
| description | The Hippo pathway is a highly conserved kinase cascade in mammals with the proteins YAP and TAZ as its most important downstream effectors that shuttle between cytoplasma and nucleus. It has a crucial role in processes such as embryogenesis, organ size control, homeostasis and tissue regeneration, where mechanosensing and/or cell-cell interactions are involved. As the pathway is associated with many essential functions in the body, its dysregulation is related to many diseases. In contrast to human pathology, a PubMed-search on Hippo, YAP/TAZ and companion animals (horse, equine, dog, canine, cat, feline) retrieved few publications. Because of its high level of functional conservation, it is anticipated that also in veterinary sciences aberrant Hippo YAP/TAZ signaling would be implicated in animal pathologies. Publications on Hippo YAP/TAZ in companion animals are mainly in cats and dogs and related to oncology. Here, we emphasize the important role of YAP/TAZ in liver diseases. First the liver has a remarkable regeneration capacity and a strict size control and the liver has a moderate liver cell renewal (homeostasis). The last years numerous papers show the importance of YAP/TAZ in hepatocellular carcinoma (HCC), hepatocyte differentiation and bile duct epithelial (BEC) cell survival. YAP/TAZ signaling is involved in activation of hepatic stellate cells crucial in fibrogenesis. The availability of drugs (e.g. verteporfin) targeting the YAP/TAZ pathway are described as is their potential usage in veterinary medicine. The aim of this overview is to stimulate researchers’ and clinicians’ interest in the potential role of Hippo YAP/TAZ signaling in veterinary medicine. |
| first_indexed | 2024-12-24T11:10:44Z |
| format | Article |
| id | doaj.art-3dc78e9099eb4067ada95325b5221e3d |
| institution | Directory Open Access Journal |
| issn | 0165-2176 1875-5941 |
| language | English |
| last_indexed | 2024-12-24T11:10:44Z |
| publishDate | 2021-12-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Veterinary Quarterly |
| spelling | doaj.art-3dc78e9099eb4067ada95325b5221e3d2022-12-21T16:58:31ZengTaylor & Francis GroupVeterinary Quarterly0165-21761875-59412021-12-0141117218010.1080/01652176.2021.19230851923085Hippo signaling pathway in companion animal diseases, an under investigated signaling cascadeShaydee J. Budel0Marloes M. Penning1Louis C. Penning2Department of Clinical Sciences, Faculty of Veterinary Medicine, Utrecht UniversityDepartment of Clinical Sciences, Faculty of Veterinary Medicine, Utrecht UniversityDepartment of Clinical Sciences, Faculty of Veterinary Medicine, Utrecht UniversityThe Hippo pathway is a highly conserved kinase cascade in mammals with the proteins YAP and TAZ as its most important downstream effectors that shuttle between cytoplasma and nucleus. It has a crucial role in processes such as embryogenesis, organ size control, homeostasis and tissue regeneration, where mechanosensing and/or cell-cell interactions are involved. As the pathway is associated with many essential functions in the body, its dysregulation is related to many diseases. In contrast to human pathology, a PubMed-search on Hippo, YAP/TAZ and companion animals (horse, equine, dog, canine, cat, feline) retrieved few publications. Because of its high level of functional conservation, it is anticipated that also in veterinary sciences aberrant Hippo YAP/TAZ signaling would be implicated in animal pathologies. Publications on Hippo YAP/TAZ in companion animals are mainly in cats and dogs and related to oncology. Here, we emphasize the important role of YAP/TAZ in liver diseases. First the liver has a remarkable regeneration capacity and a strict size control and the liver has a moderate liver cell renewal (homeostasis). The last years numerous papers show the importance of YAP/TAZ in hepatocellular carcinoma (HCC), hepatocyte differentiation and bile duct epithelial (BEC) cell survival. YAP/TAZ signaling is involved in activation of hepatic stellate cells crucial in fibrogenesis. The availability of drugs (e.g. verteporfin) targeting the YAP/TAZ pathway are described as is their potential usage in veterinary medicine. The aim of this overview is to stimulate researchers’ and clinicians’ interest in the potential role of Hippo YAP/TAZ signaling in veterinary medicine.http://dx.doi.org/10.1080/01652176.2021.1923085equinecaninefelinehippo pathwayyap/taz signalinglivermammary glandverteporfin |
| spellingShingle | Shaydee J. Budel Marloes M. Penning Louis C. Penning Hippo signaling pathway in companion animal diseases, an under investigated signaling cascade Veterinary Quarterly equine canine feline hippo pathway yap/taz signaling liver mammary gland verteporfin |
| title | Hippo signaling pathway in companion animal diseases, an under investigated signaling cascade |
| title_full | Hippo signaling pathway in companion animal diseases, an under investigated signaling cascade |
| title_fullStr | Hippo signaling pathway in companion animal diseases, an under investigated signaling cascade |
| title_full_unstemmed | Hippo signaling pathway in companion animal diseases, an under investigated signaling cascade |
| title_short | Hippo signaling pathway in companion animal diseases, an under investigated signaling cascade |
| title_sort | hippo signaling pathway in companion animal diseases an under investigated signaling cascade |
| topic | equine canine feline hippo pathway yap/taz signaling liver mammary gland verteporfin |
| url | http://dx.doi.org/10.1080/01652176.2021.1923085 |
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