A Nectin1 Mutant Mouse Model Is Resistant to Pseudorabies Virus Infection

A Nectin1 Mutant Mouse Model Is Resistant to Pseudorabies Virus Infection

The present study generated nectin1-mutant mice with single amino acid substitution and tested the anti-pseudorabies virus (PRV) ability of the mutant mice, with the aim to establish a model for PRV-resistant livestock. A phenylalanine to alanine transition at position 129 (F129A) of nectin1 was int...

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Bibliographic Details
Main Authors: Xiaohui Yang, Chuanzhao Yu, Qiuyan Zhang, Linjun Hong, Ting Gu, Enqin Zheng, Zheng Xu, Zicong Li, Changxu Song, Gengyuan Cai, Zhenfang Wu, Huaqiang Yang
Format: Article
Language:English
Published: MDPI AG 2022-04-01
Series:Viruses
Subjects:
antiviral breeding
genetic modification
nectin1
pig
PRV
disease resistance
Online Access:https://www.mdpi.com/1999-4915/14/5/874

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