Hypoxia-induced signaling in the cardiovascular system: pathogenesis and therapeutic targets
Abstract Hypoxia, characterized by reduced oxygen concentration, is a significant stressor that affects the survival of aerobic species and plays a prominent role in cardiovascular diseases. From the research history and milestone events related to hypoxia in cardiovascular development and diseases,...
| Main Authors: | , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Nature Publishing Group
2023-11-01
|
| Series: | Signal Transduction and Targeted Therapy |
| Online Access: | https://doi.org/10.1038/s41392-023-01652-9 |
| _version_ | 1797451328394362880 |
|---|---|
| author | Yongchao Zhao Weidong Xiong Chaofu Li Ranzun Zhao Hao Lu Shuai Song You Zhou Yiqing Hu Bei Shi Junbo Ge |
| author_facet | Yongchao Zhao Weidong Xiong Chaofu Li Ranzun Zhao Hao Lu Shuai Song You Zhou Yiqing Hu Bei Shi Junbo Ge |
| author_sort | Yongchao Zhao |
| collection | DOAJ |
| description | Abstract Hypoxia, characterized by reduced oxygen concentration, is a significant stressor that affects the survival of aerobic species and plays a prominent role in cardiovascular diseases. From the research history and milestone events related to hypoxia in cardiovascular development and diseases, The "hypoxia-inducible factors (HIFs) switch" can be observed from both temporal and spatial perspectives, encompassing the occurrence and progression of hypoxia (gradual decline in oxygen concentration), the acute and chronic manifestations of hypoxia, and the geographical characteristics of hypoxia (natural selection at high altitudes). Furthermore, hypoxia signaling pathways are associated with natural rhythms, such as diurnal and hibernation processes. In addition to innate factors and natural selection, it has been found that epigenetics, as a postnatal factor, profoundly influences the hypoxic response and progression within the cardiovascular system. Within this intricate process, interactions between different tissues and organs within the cardiovascular system and other systems in the context of hypoxia signaling pathways have been established. Thus, it is the time to summarize and to construct a multi-level regulatory framework of hypoxia signaling and mechanisms in cardiovascular diseases for developing more therapeutic targets and make reasonable advancements in clinical research, including FDA-approved drugs and ongoing clinical trials, to guide future clinical practice in the field of hypoxia signaling in cardiovascular diseases. |
| first_indexed | 2024-03-09T14:52:10Z |
| format | Article |
| id | doaj.art-3dc88a23ba0d4dccac47252dac8a6792 |
| institution | Directory Open Access Journal |
| issn | 2059-3635 |
| language | English |
| last_indexed | 2024-03-09T14:52:10Z |
| publishDate | 2023-11-01 |
| publisher | Nature Publishing Group |
| record_format | Article |
| series | Signal Transduction and Targeted Therapy |
| spelling | doaj.art-3dc88a23ba0d4dccac47252dac8a67922023-11-26T14:22:22ZengNature Publishing GroupSignal Transduction and Targeted Therapy2059-36352023-11-018114210.1038/s41392-023-01652-9Hypoxia-induced signaling in the cardiovascular system: pathogenesis and therapeutic targetsYongchao Zhao0Weidong Xiong1Chaofu Li2Ranzun Zhao3Hao Lu4Shuai Song5You Zhou6Yiqing Hu7Bei Shi8Junbo Ge9Department of Cardiology, Affiliated Hospital of Zunyi Medical UniversityDepartment of Cardiology, Affiliated Hospital of Zunyi Medical UniversityDepartment of Cardiology, Affiliated Hospital of Zunyi Medical UniversityDepartment of Cardiology, Affiliated Hospital of Zunyi Medical UniversityDepartment of Cardiology, Zhongshan Hospital, Fudan University, Shanghai Institute of Cardiovascular DiseasesDepartment of Cardiology, Zhongshan Hospital, Fudan University, Shanghai Institute of Cardiovascular DiseasesDepartment of Cardiology, Zhongshan Hospital, Fudan University, Shanghai Institute of Cardiovascular DiseasesDepartment of Cardiology, Zhongshan Hospital, Fudan University, Shanghai Institute of Cardiovascular DiseasesDepartment of Cardiology, Affiliated Hospital of Zunyi Medical UniversityDepartment of Cardiology, Affiliated Hospital of Zunyi Medical UniversityAbstract Hypoxia, characterized by reduced oxygen concentration, is a significant stressor that affects the survival of aerobic species and plays a prominent role in cardiovascular diseases. From the research history and milestone events related to hypoxia in cardiovascular development and diseases, The "hypoxia-inducible factors (HIFs) switch" can be observed from both temporal and spatial perspectives, encompassing the occurrence and progression of hypoxia (gradual decline in oxygen concentration), the acute and chronic manifestations of hypoxia, and the geographical characteristics of hypoxia (natural selection at high altitudes). Furthermore, hypoxia signaling pathways are associated with natural rhythms, such as diurnal and hibernation processes. In addition to innate factors and natural selection, it has been found that epigenetics, as a postnatal factor, profoundly influences the hypoxic response and progression within the cardiovascular system. Within this intricate process, interactions between different tissues and organs within the cardiovascular system and other systems in the context of hypoxia signaling pathways have been established. Thus, it is the time to summarize and to construct a multi-level regulatory framework of hypoxia signaling and mechanisms in cardiovascular diseases for developing more therapeutic targets and make reasonable advancements in clinical research, including FDA-approved drugs and ongoing clinical trials, to guide future clinical practice in the field of hypoxia signaling in cardiovascular diseases.https://doi.org/10.1038/s41392-023-01652-9 |
| spellingShingle | Yongchao Zhao Weidong Xiong Chaofu Li Ranzun Zhao Hao Lu Shuai Song You Zhou Yiqing Hu Bei Shi Junbo Ge Hypoxia-induced signaling in the cardiovascular system: pathogenesis and therapeutic targets Signal Transduction and Targeted Therapy |
| title | Hypoxia-induced signaling in the cardiovascular system: pathogenesis and therapeutic targets |
| title_full | Hypoxia-induced signaling in the cardiovascular system: pathogenesis and therapeutic targets |
| title_fullStr | Hypoxia-induced signaling in the cardiovascular system: pathogenesis and therapeutic targets |
| title_full_unstemmed | Hypoxia-induced signaling in the cardiovascular system: pathogenesis and therapeutic targets |
| title_short | Hypoxia-induced signaling in the cardiovascular system: pathogenesis and therapeutic targets |
| title_sort | hypoxia induced signaling in the cardiovascular system pathogenesis and therapeutic targets |
| url | https://doi.org/10.1038/s41392-023-01652-9 |
| work_keys_str_mv | AT yongchaozhao hypoxiainducedsignalinginthecardiovascularsystempathogenesisandtherapeutictargets AT weidongxiong hypoxiainducedsignalinginthecardiovascularsystempathogenesisandtherapeutictargets AT chaofuli hypoxiainducedsignalinginthecardiovascularsystempathogenesisandtherapeutictargets AT ranzunzhao hypoxiainducedsignalinginthecardiovascularsystempathogenesisandtherapeutictargets AT haolu hypoxiainducedsignalinginthecardiovascularsystempathogenesisandtherapeutictargets AT shuaisong hypoxiainducedsignalinginthecardiovascularsystempathogenesisandtherapeutictargets AT youzhou hypoxiainducedsignalinginthecardiovascularsystempathogenesisandtherapeutictargets AT yiqinghu hypoxiainducedsignalinginthecardiovascularsystempathogenesisandtherapeutictargets AT beishi hypoxiainducedsignalinginthecardiovascularsystempathogenesisandtherapeutictargets AT junboge hypoxiainducedsignalinginthecardiovascularsystempathogenesisandtherapeutictargets |