Mycobacterium tuberculosis KasA as a drug target: Structure-based inhibitor design

Mycobacterium tuberculosis KasA as a drug target: Structure-based inhibitor design

Recent studies have reported the β-ketoacyl-acyl carrier protein KasA as a druggable target for Mycobacterium tuberculosis. This review summarizes the current status of major classes of KasA inhibitors with an emphasis on significant contributions from structure-based design methods leveraging X-ray...

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Bibliographic Details
Main Authors: Reshma S. Rudraraju, Samer S. Daher, Ricardo Gallardo-Macias, Xin Wang, Matthew B. Neiditch, Joel S. Freundlich
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-09-01
Series:Frontiers in Cellular and Infection Microbiology
Subjects:
mycobacterium tuberculosis
KasA
β-ketoacyl synthase
structure-based drug discovery
medicinal chemistry
Online Access:https://www.frontiersin.org/articles/10.3389/fcimb.2022.1008213/full

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