Associations between neutrophil-lymphocyte ratio and monocyte to high-density lipoprotein ratio with left atrial spontaneous echo contrast or thrombus in patients with non-valvular atrial fibrillation
Abstract Background The importance of inflammation in thrombosis is increasingly appreciated. Neutrophil-lymphocyte ratio (NLR) and monocyte to high-density lipoprotein ratio (MHR) are important indicators of systemic inflammation. This study aimed to investigate the associations between NLR and MHR...
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| Format: | Article |
| Language: | English |
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BMC
2023-05-01
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| Series: | BMC Cardiovascular Disorders |
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| Online Access: | https://doi.org/10.1186/s12872-023-03270-3 |
| _version_ | 1827952858437255168 |
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| author | Yingjian Deng Faguang Zhou Qiang Li Jincun Guo Binni Cai Guiyang Li Jianghai Liu Linlin Li Qi Zheng Dong Chang |
| author_facet | Yingjian Deng Faguang Zhou Qiang Li Jincun Guo Binni Cai Guiyang Li Jianghai Liu Linlin Li Qi Zheng Dong Chang |
| author_sort | Yingjian Deng |
| collection | DOAJ |
| description | Abstract Background The importance of inflammation in thrombosis is increasingly appreciated. Neutrophil-lymphocyte ratio (NLR) and monocyte to high-density lipoprotein ratio (MHR) are important indicators of systemic inflammation. This study aimed to investigate the associations between NLR and MHR with left atrial appendage thrombus (LAAT) and spontaneous echo contrast (SEC) in patients with non-valvular atrial fibrillation. Methods This retrospective, cross-sectional study enrolled 569 consecutive patients with non-valvular atrial fibrillation. Multivariable logistic regression analysis was used to investigate independent risk factors of LAAT/SEC. Receiver operating characteristic (ROC) curves were used to evaluate the specificity and sensitivity of NLR and MHR in predicting LAAT/SEC. Subgroup and Pearson correlation analyses were used to assess the correlations between NLR and MHR with the CHA2DS2-VASc score. Results Multivariate logistic regression analysis showed that NLR (OR: 1.49; 95%CI: 1.173–1.892) and MHR (OR: 2.951; 95%CI: 1.045–8.336) were independent risk factors for LAAT/SEC. The area under the ROC curve of NLR (0.639) and MHR (0.626) was similar to that of the CHADS2 score (0.660) and CHA2DS2-VASc score (0.637). Subgroup and Pearson correlation analyses showed significant but very weak associations between NLR (r = 0.139, P < 0.05) and MHR (r = 0.095, P < 0.05) with the CHA2DS2-VASc score. Conclusion Generally, NLR and MHR are independent risk factors for predicting LAAT/SEC in patients with non-valvular atrial fibrillation. |
| first_indexed | 2024-04-09T14:05:16Z |
| format | Article |
| id | doaj.art-3dc9c1ee1e4b4559a18451e5e45356db |
| institution | Directory Open Access Journal |
| issn | 1471-2261 |
| language | English |
| last_indexed | 2024-04-09T14:05:16Z |
| publishDate | 2023-05-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Cardiovascular Disorders |
| spelling | doaj.art-3dc9c1ee1e4b4559a18451e5e45356db2023-05-07T11:04:52ZengBMCBMC Cardiovascular Disorders1471-22612023-05-012311910.1186/s12872-023-03270-3Associations between neutrophil-lymphocyte ratio and monocyte to high-density lipoprotein ratio with left atrial spontaneous echo contrast or thrombus in patients with non-valvular atrial fibrillationYingjian Deng0Faguang Zhou1Qiang Li2Jincun Guo3Binni Cai4Guiyang Li5Jianghai Liu6Linlin Li7Qi Zheng8Dong Chang9Department of Cardiology, School of Medicine, Xiamen Cardiovascular Hospital of Xiamen University, Xiamen UniversityDepartment of Cardiology, School of Medicine, Xiamen Cardiovascular Hospital of Xiamen University, Xiamen UniversityDepartment of Cardiology, School of Medicine, Xiamen Cardiovascular Hospital of Xiamen University, Xiamen UniversityDepartment of Cardiology, School of Medicine, Xiamen Cardiovascular Hospital of Xiamen University, Xiamen UniversityDepartment of Cardiology, School of Medicine, Xiamen Cardiovascular Hospital of Xiamen University, Xiamen UniversityDepartment of Cardiology, School of Medicine, Xiamen Cardiovascular Hospital of Xiamen University, Xiamen UniversityDepartment of Cardiology, School of Medicine, Xiamen Cardiovascular Hospital of Xiamen University, Xiamen UniversityDepartment of Cardiology, School of Medicine, Xiamen Cardiovascular Hospital of Xiamen University, Xiamen UniversityDepartment of Psychology, Xiamen Xianyue HospitalDepartment of Cardiology, School of Medicine, Xiamen Cardiovascular Hospital of Xiamen University, Xiamen UniversityAbstract Background The importance of inflammation in thrombosis is increasingly appreciated. Neutrophil-lymphocyte ratio (NLR) and monocyte to high-density lipoprotein ratio (MHR) are important indicators of systemic inflammation. This study aimed to investigate the associations between NLR and MHR with left atrial appendage thrombus (LAAT) and spontaneous echo contrast (SEC) in patients with non-valvular atrial fibrillation. Methods This retrospective, cross-sectional study enrolled 569 consecutive patients with non-valvular atrial fibrillation. Multivariable logistic regression analysis was used to investigate independent risk factors of LAAT/SEC. Receiver operating characteristic (ROC) curves were used to evaluate the specificity and sensitivity of NLR and MHR in predicting LAAT/SEC. Subgroup and Pearson correlation analyses were used to assess the correlations between NLR and MHR with the CHA2DS2-VASc score. Results Multivariate logistic regression analysis showed that NLR (OR: 1.49; 95%CI: 1.173–1.892) and MHR (OR: 2.951; 95%CI: 1.045–8.336) were independent risk factors for LAAT/SEC. The area under the ROC curve of NLR (0.639) and MHR (0.626) was similar to that of the CHADS2 score (0.660) and CHA2DS2-VASc score (0.637). Subgroup and Pearson correlation analyses showed significant but very weak associations between NLR (r = 0.139, P < 0.05) and MHR (r = 0.095, P < 0.05) with the CHA2DS2-VASc score. Conclusion Generally, NLR and MHR are independent risk factors for predicting LAAT/SEC in patients with non-valvular atrial fibrillation.https://doi.org/10.1186/s12872-023-03270-3Atrial fibrillationStrokeLeft atrial appendage thrombusSpontaneous echo contrastNeutrophil-lymphocyte ratioMonocyte to high-density lipoprotein ratio |
| spellingShingle | Yingjian Deng Faguang Zhou Qiang Li Jincun Guo Binni Cai Guiyang Li Jianghai Liu Linlin Li Qi Zheng Dong Chang Associations between neutrophil-lymphocyte ratio and monocyte to high-density lipoprotein ratio with left atrial spontaneous echo contrast or thrombus in patients with non-valvular atrial fibrillation BMC Cardiovascular Disorders Atrial fibrillation Stroke Left atrial appendage thrombus Spontaneous echo contrast Neutrophil-lymphocyte ratio Monocyte to high-density lipoprotein ratio |
| title | Associations between neutrophil-lymphocyte ratio and monocyte to high-density lipoprotein ratio with left atrial spontaneous echo contrast or thrombus in patients with non-valvular atrial fibrillation |
| title_full | Associations between neutrophil-lymphocyte ratio and monocyte to high-density lipoprotein ratio with left atrial spontaneous echo contrast or thrombus in patients with non-valvular atrial fibrillation |
| title_fullStr | Associations between neutrophil-lymphocyte ratio and monocyte to high-density lipoprotein ratio with left atrial spontaneous echo contrast or thrombus in patients with non-valvular atrial fibrillation |
| title_full_unstemmed | Associations between neutrophil-lymphocyte ratio and monocyte to high-density lipoprotein ratio with left atrial spontaneous echo contrast or thrombus in patients with non-valvular atrial fibrillation |
| title_short | Associations between neutrophil-lymphocyte ratio and monocyte to high-density lipoprotein ratio with left atrial spontaneous echo contrast or thrombus in patients with non-valvular atrial fibrillation |
| title_sort | associations between neutrophil lymphocyte ratio and monocyte to high density lipoprotein ratio with left atrial spontaneous echo contrast or thrombus in patients with non valvular atrial fibrillation |
| topic | Atrial fibrillation Stroke Left atrial appendage thrombus Spontaneous echo contrast Neutrophil-lymphocyte ratio Monocyte to high-density lipoprotein ratio |
| url | https://doi.org/10.1186/s12872-023-03270-3 |
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