Preoperative ALBI grade predicts the outcomes in non-B non-C HCC patients undergoing primary curative resection
Abstract Background The albumin–bilirubin (ALBI) grade has been validated as a significant prognostic predictor for hepatocellular carcinoma (HCC). However, there is little information about the ALBI grade in patients with non-B non-C HCC (NBNC-HCC) receiving surgery. Aim This study aimed to evaluat...
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| Format: | Article |
| Language: | English |
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BMC
2021-10-01
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| Series: | BMC Gastroenterology |
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| Online Access: | https://doi.org/10.1186/s12876-021-01944-w |
| _version_ | 1828956371058425856 |
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| author | Yu-Chieh Tsai Fai-Meng Sou Yueh-Wei Liu Yi-Ju Wu Chee-Chien Yong Ding-Wei Chen Pao-Yuan Huang Wei-Ru Cho Ching-Hui Chuang Chang-Chun Hsiao Tsung-Hui Hu Ming-Chao Tsai |
| author_facet | Yu-Chieh Tsai Fai-Meng Sou Yueh-Wei Liu Yi-Ju Wu Chee-Chien Yong Ding-Wei Chen Pao-Yuan Huang Wei-Ru Cho Ching-Hui Chuang Chang-Chun Hsiao Tsung-Hui Hu Ming-Chao Tsai |
| author_sort | Yu-Chieh Tsai |
| collection | DOAJ |
| description | Abstract Background The albumin–bilirubin (ALBI) grade has been validated as a significant prognostic predictor for hepatocellular carcinoma (HCC). However, there is little information about the ALBI grade in patients with non-B non-C HCC (NBNC-HCC) receiving surgery. Aim This study aimed to evaluate the prognostic significance of the ALBI grade in patients with NBNC-HCC after primary curative resection. Method From January 2010 to April 2016, 2137 patients with HCC who received hepatectomy were screened for study eligibility. Finally, a total of 168 NBNC-HCC patients who received primary curative resection were analyzed. The impacts of the ALBI grade on disease-free survival (DFS) and overall survival (OS) were analyzed by multivariate analysis. Results There were 66 (39.3%), 98 (58.3%), and 4 (2.4%) patients with an ALBI grade of I, II, and III, respectively. Patients with an ALBI grade II/III were older (p = 0.002), more likely to have hypoalbuminemia (p < 0.001), and more commonly had Child–Pugh class B (p = 0.009) than patients with an ALBI grade I. After a median follow-up of 76 months, 74 (44%) patients experienced recurrence, and 72 (42.9%) patients died. Multivariate analysis revealed that alpha-fetoprotein (AFP) > 200 ng/mL (p = 0.021), number of tumors (p = 0.001), and tumor stage (p = 0.007) were independent prognostic factors for DFS. Additionally, AFP > 200 ng/mL (p = 0.002), ALBI grade II/III (p = 0.002), and tumor stage (p < 0.001) were independent risk factors for poor OS. Conclusion The preoperative ALBI grade can be used to predict mortality in patients with NBNC-HCC after primary curative resection. |
| first_indexed | 2024-12-14T08:10:36Z |
| format | Article |
| id | doaj.art-3dcac68e63b24408b4555537b8b40c60 |
| institution | Directory Open Access Journal |
| issn | 1471-230X |
| language | English |
| last_indexed | 2024-12-14T08:10:36Z |
| publishDate | 2021-10-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Gastroenterology |
| spelling | doaj.art-3dcac68e63b24408b4555537b8b40c602022-12-21T23:10:05ZengBMCBMC Gastroenterology1471-230X2021-10-012111910.1186/s12876-021-01944-wPreoperative ALBI grade predicts the outcomes in non-B non-C HCC patients undergoing primary curative resectionYu-Chieh Tsai0Fai-Meng Sou1Yueh-Wei Liu2Yi-Ju Wu3Chee-Chien Yong4Ding-Wei Chen5Pao-Yuan Huang6Wei-Ru Cho7Ching-Hui Chuang8Chang-Chun Hsiao9Tsung-Hui Hu10Ming-Chao Tsai11Division of Hepato-Gastroenterology, Department of Internal Medicine, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of MedicineDivision of Hepato-Gastroenterology, Department of Internal Medicine, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of MedicineLiver Transplantation Center and Department of Surgery, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of MedicineLiver Transplantation Center and Department of Surgery, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of MedicineLiver Transplantation Center and Department of Surgery, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of MedicineCenter for Translational Research in Biomedical Sciences, Liver Transplantation Program and Department of Surgery, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of MedicineDivision of Hepato-Gastroenterology, Department of Internal Medicine, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of MedicineDivision of Hepato-Gastroenterology, Department of Internal Medicine, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of MedicineDepartment of Nursing, Meiho UniversityGraduate Institute of Clinical Medical Sciences, College of Medicine, Chang Gung University, Division of Pulmonary and Critical Care Medicine, Kaohsiung Chang Gung Memorial HospitalDivision of Hepato-Gastroenterology, Department of Internal Medicine, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of MedicineDivision of Hepato-Gastroenterology, Department of Internal Medicine, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of MedicineAbstract Background The albumin–bilirubin (ALBI) grade has been validated as a significant prognostic predictor for hepatocellular carcinoma (HCC). However, there is little information about the ALBI grade in patients with non-B non-C HCC (NBNC-HCC) receiving surgery. Aim This study aimed to evaluate the prognostic significance of the ALBI grade in patients with NBNC-HCC after primary curative resection. Method From January 2010 to April 2016, 2137 patients with HCC who received hepatectomy were screened for study eligibility. Finally, a total of 168 NBNC-HCC patients who received primary curative resection were analyzed. The impacts of the ALBI grade on disease-free survival (DFS) and overall survival (OS) were analyzed by multivariate analysis. Results There were 66 (39.3%), 98 (58.3%), and 4 (2.4%) patients with an ALBI grade of I, II, and III, respectively. Patients with an ALBI grade II/III were older (p = 0.002), more likely to have hypoalbuminemia (p < 0.001), and more commonly had Child–Pugh class B (p = 0.009) than patients with an ALBI grade I. After a median follow-up of 76 months, 74 (44%) patients experienced recurrence, and 72 (42.9%) patients died. Multivariate analysis revealed that alpha-fetoprotein (AFP) > 200 ng/mL (p = 0.021), number of tumors (p = 0.001), and tumor stage (p = 0.007) were independent prognostic factors for DFS. Additionally, AFP > 200 ng/mL (p = 0.002), ALBI grade II/III (p = 0.002), and tumor stage (p < 0.001) were independent risk factors for poor OS. Conclusion The preoperative ALBI grade can be used to predict mortality in patients with NBNC-HCC after primary curative resection.https://doi.org/10.1186/s12876-021-01944-wALBINBNCHepatocellular carcinomaResectionRecurrence |
| spellingShingle | Yu-Chieh Tsai Fai-Meng Sou Yueh-Wei Liu Yi-Ju Wu Chee-Chien Yong Ding-Wei Chen Pao-Yuan Huang Wei-Ru Cho Ching-Hui Chuang Chang-Chun Hsiao Tsung-Hui Hu Ming-Chao Tsai Preoperative ALBI grade predicts the outcomes in non-B non-C HCC patients undergoing primary curative resection BMC Gastroenterology ALBI NBNC Hepatocellular carcinoma Resection Recurrence |
| title | Preoperative ALBI grade predicts the outcomes in non-B non-C HCC patients undergoing primary curative resection |
| title_full | Preoperative ALBI grade predicts the outcomes in non-B non-C HCC patients undergoing primary curative resection |
| title_fullStr | Preoperative ALBI grade predicts the outcomes in non-B non-C HCC patients undergoing primary curative resection |
| title_full_unstemmed | Preoperative ALBI grade predicts the outcomes in non-B non-C HCC patients undergoing primary curative resection |
| title_short | Preoperative ALBI grade predicts the outcomes in non-B non-C HCC patients undergoing primary curative resection |
| title_sort | preoperative albi grade predicts the outcomes in non b non c hcc patients undergoing primary curative resection |
| topic | ALBI NBNC Hepatocellular carcinoma Resection Recurrence |
| url | https://doi.org/10.1186/s12876-021-01944-w |
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