Hubungan Kadar Leptin Serum dengan Kompleksitas Lesi Koroner berdasarkan Skor SYNTAX pada Penderita Penyakit Arteri Koroner Stabil
Leptin has been shown to play a potential role in the atherosclerotic plaque formation by activating immune and inflammatory cells or directly acting on the vessel wall. Earlier reports of the correlation of serum leptin levels with the degree of coronary lesion stated are still controversial. This...
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| Format: | Article |
| Language: | English |
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Universitas Padjajaran
2016-05-01
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| Series: | Majalah Kedokteran Bandung |
| Subjects: | |
| Online Access: | http://journal.fk.unpad.ac.id/index.php/mkb/article/view/730 |
| _version_ | 1818164083732512768 |
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| author | Fajar Ashari Toni Mustahsani Aprami Muhammad Rizki Akbar Augustine Purnomowati Januar Wibawa Martha Chaerul Achmad Erwan Martanto |
| author_facet | Fajar Ashari Toni Mustahsani Aprami Muhammad Rizki Akbar Augustine Purnomowati Januar Wibawa Martha Chaerul Achmad Erwan Martanto |
| author_sort | Fajar Ashari |
| collection | DOAJ |
| description | Leptin has been shown to play a potential role in the atherosclerotic plaque formation by activating immune and inflammatory cells or directly acting on the vessel wall. Earlier reports of the correlation of serum leptin levels with the degree of coronary lesion stated are still controversial. This study determined the correlation between serum leptin levels and complexity of coronary artery lesion in patients with stable coronary artery disease (SCAD). This is an observational cross-sectional study. Data were collected from January to May 2014 in Dr. Hasan Sadikin Central General Hospital Bandung. Blood samples were collected before angiography procedures. The complexity of coronary artery lesion was assessed using SYNTAX score. There were 44 patients who met inclusion criteria, male 84%, median age 54.68 (+10.24) years. Mean body mass index 24.71 (+ 3.05) kg/m2. Dyslipidemia was the most common risk factor (84%), followed by smoking (72%), hypertension (38.4%), diabetes mellitus (22.7%), and obesity (4.5%). Median leptin level was 7,242 (780-36,929) pq/mL. Mean SYNTAX score was 19.52 (+9.93). Leptin level had no correlation with the complexity of coronary artery lesion (p=0.61, r=0.078). The difference between this study from prior studies might be caused by differences in subject selection and criteria used for complexity of coronary artery lesion. In conclusion, there is no correlation between serum leptin levels and complexity of coronary artery lesion in patients with stable coronary artery disease. |
| first_indexed | 2024-12-11T16:59:49Z |
| format | Article |
| id | doaj.art-3dcae68ebf92461582d79efb983dc73e |
| institution | Directory Open Access Journal |
| issn | 0126-074X 2338-6223 |
| language | English |
| last_indexed | 2024-12-11T16:59:49Z |
| publishDate | 2016-05-01 |
| publisher | Universitas Padjajaran |
| record_format | Article |
| series | Majalah Kedokteran Bandung |
| spelling | doaj.art-3dcae68ebf92461582d79efb983dc73e2022-12-22T00:57:52ZengUniversitas PadjajaranMajalah Kedokteran Bandung0126-074X2338-62232016-05-01481263110.15395/mkb.v48n1.730Hubungan Kadar Leptin Serum dengan Kompleksitas Lesi Koroner berdasarkan Skor SYNTAX pada Penderita Penyakit Arteri Koroner StabilFajar Ashari0Toni Mustahsani Aprami1Muhammad Rizki Akbar2Augustine Purnomowati3Januar Wibawa Martha4Chaerul Achmad5Erwan Martanto6Rumah Sakit Al-Islam BandungDepartemen Ilmu Penyakit Dalam Fakultas Kedokteran Universitas Padjadjaran Rumah Sakit Dr. Hasan Sadikin BandungDepartemen Ilmu Penyakit Dalam Fakultas Kedokteran Universitas Padjadjaran Rumah Sakit Dr. Hasan Sadikin BandungDepartemen Ilmu Penyakit Dalam Fakultas Kedokteran Universitas Padjadjaran Rumah Sakit Dr. Hasan Sadikin BandungDepartemen Ilmu Penyakit Dalam Fakultas Kedokteran Universitas Padjadjaran Rumah Sakit Dr. Hasan Sadikin BandungDepartemen Ilmu Penyakit Dalam Fakultas Kedokteran Universitas Padjadjaran Rumah Sakit Dr. Hasan Sadikin BandungDepartemen Ilmu Penyakit Dalam Fakultas Kedokteran Universitas Padjadjaran Rumah Sakit Dr. Hasan Sadikin BandungLeptin has been shown to play a potential role in the atherosclerotic plaque formation by activating immune and inflammatory cells or directly acting on the vessel wall. Earlier reports of the correlation of serum leptin levels with the degree of coronary lesion stated are still controversial. This study determined the correlation between serum leptin levels and complexity of coronary artery lesion in patients with stable coronary artery disease (SCAD). This is an observational cross-sectional study. Data were collected from January to May 2014 in Dr. Hasan Sadikin Central General Hospital Bandung. Blood samples were collected before angiography procedures. The complexity of coronary artery lesion was assessed using SYNTAX score. There were 44 patients who met inclusion criteria, male 84%, median age 54.68 (+10.24) years. Mean body mass index 24.71 (+ 3.05) kg/m2. Dyslipidemia was the most common risk factor (84%), followed by smoking (72%), hypertension (38.4%), diabetes mellitus (22.7%), and obesity (4.5%). Median leptin level was 7,242 (780-36,929) pq/mL. Mean SYNTAX score was 19.52 (+9.93). Leptin level had no correlation with the complexity of coronary artery lesion (p=0.61, r=0.078). The difference between this study from prior studies might be caused by differences in subject selection and criteria used for complexity of coronary artery lesion. In conclusion, there is no correlation between serum leptin levels and complexity of coronary artery lesion in patients with stable coronary artery disease.http://journal.fk.unpad.ac.id/index.php/mkb/article/view/730Complexity of coronary artery lesionleptinstable coronary artery diseaseSYNTAX score |
| spellingShingle | Fajar Ashari Toni Mustahsani Aprami Muhammad Rizki Akbar Augustine Purnomowati Januar Wibawa Martha Chaerul Achmad Erwan Martanto Hubungan Kadar Leptin Serum dengan Kompleksitas Lesi Koroner berdasarkan Skor SYNTAX pada Penderita Penyakit Arteri Koroner Stabil Majalah Kedokteran Bandung Complexity of coronary artery lesion leptin stable coronary artery disease SYNTAX score |
| title | Hubungan Kadar Leptin Serum dengan Kompleksitas Lesi Koroner berdasarkan Skor SYNTAX pada Penderita Penyakit Arteri Koroner Stabil |
| title_full | Hubungan Kadar Leptin Serum dengan Kompleksitas Lesi Koroner berdasarkan Skor SYNTAX pada Penderita Penyakit Arteri Koroner Stabil |
| title_fullStr | Hubungan Kadar Leptin Serum dengan Kompleksitas Lesi Koroner berdasarkan Skor SYNTAX pada Penderita Penyakit Arteri Koroner Stabil |
| title_full_unstemmed | Hubungan Kadar Leptin Serum dengan Kompleksitas Lesi Koroner berdasarkan Skor SYNTAX pada Penderita Penyakit Arteri Koroner Stabil |
| title_short | Hubungan Kadar Leptin Serum dengan Kompleksitas Lesi Koroner berdasarkan Skor SYNTAX pada Penderita Penyakit Arteri Koroner Stabil |
| title_sort | hubungan kadar leptin serum dengan kompleksitas lesi koroner berdasarkan skor syntax pada penderita penyakit arteri koroner stabil |
| topic | Complexity of coronary artery lesion leptin stable coronary artery disease SYNTAX score |
| url | http://journal.fk.unpad.ac.id/index.php/mkb/article/view/730 |
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