Growth inhibition of cytosolic Salmonella by caspase-1 and caspase-11 precedes host cell death
Inflammatory caspases restrict microbial growth by inducing cytokine production and pyroptosis, but other caspase-induced mechanisms are thought to contribute. Here the authors use time-lapse microscopy of single cells to show that caspase1/11 has anti-Salmonella functions that occur in advance of c...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2016-11-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/ncomms13292 |
| _version_ | 1818952117457518592 |
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| author | Teresa L. M. Thurston Sophie A. Matthews Elliott Jennings Eric Alix Feng Shao Avinash R. Shenoy Mark A. Birrell David W. Holden |
| author_facet | Teresa L. M. Thurston Sophie A. Matthews Elliott Jennings Eric Alix Feng Shao Avinash R. Shenoy Mark A. Birrell David W. Holden |
| author_sort | Teresa L. M. Thurston |
| collection | DOAJ |
| description | Inflammatory caspases restrict microbial growth by inducing cytokine production and pyroptosis, but other caspase-induced mechanisms are thought to contribute. Here the authors use time-lapse microscopy of single cells to show that caspase1/11 has anti-Salmonella functions that occur in advance of cell death induction. |
| first_indexed | 2024-12-20T09:45:17Z |
| format | Article |
| id | doaj.art-3dcaf1a910524de0b958aea81b142880 |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-12-20T09:45:17Z |
| publishDate | 2016-11-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-3dcaf1a910524de0b958aea81b1428802022-12-21T19:44:46ZengNature PortfolioNature Communications2041-17232016-11-017111510.1038/ncomms13292Growth inhibition of cytosolic Salmonella by caspase-1 and caspase-11 precedes host cell deathTeresa L. M. Thurston0Sophie A. Matthews1Elliott Jennings2Eric Alix3Feng Shao4Avinash R. Shenoy5Mark A. Birrell6David W. Holden7MRC Centre for Molecular Bacteriology and Infection, Imperial College LondonMRC Centre for Molecular Bacteriology and Infection, Imperial College LondonMRC Centre for Molecular Bacteriology and Infection, Imperial College LondonMRC Centre for Molecular Bacteriology and Infection, Imperial College LondonNational Institute of Biological SciencesMRC Centre for Molecular Bacteriology and Infection, Imperial College LondonRespiratory Pharmacology, Pharmacology & Toxicology Section, Imperial College LondonMRC Centre for Molecular Bacteriology and Infection, Imperial College LondonInflammatory caspases restrict microbial growth by inducing cytokine production and pyroptosis, but other caspase-induced mechanisms are thought to contribute. Here the authors use time-lapse microscopy of single cells to show that caspase1/11 has anti-Salmonella functions that occur in advance of cell death induction.https://doi.org/10.1038/ncomms13292 |
| spellingShingle | Teresa L. M. Thurston Sophie A. Matthews Elliott Jennings Eric Alix Feng Shao Avinash R. Shenoy Mark A. Birrell David W. Holden Growth inhibition of cytosolic Salmonella by caspase-1 and caspase-11 precedes host cell death Nature Communications |
| title | Growth inhibition of cytosolic Salmonella by caspase-1 and caspase-11 precedes host cell death |
| title_full | Growth inhibition of cytosolic Salmonella by caspase-1 and caspase-11 precedes host cell death |
| title_fullStr | Growth inhibition of cytosolic Salmonella by caspase-1 and caspase-11 precedes host cell death |
| title_full_unstemmed | Growth inhibition of cytosolic Salmonella by caspase-1 and caspase-11 precedes host cell death |
| title_short | Growth inhibition of cytosolic Salmonella by caspase-1 and caspase-11 precedes host cell death |
| title_sort | growth inhibition of cytosolic salmonella by caspase 1 and caspase 11 precedes host cell death |
| url | https://doi.org/10.1038/ncomms13292 |
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