The Effect of Probiotics on Symptoms, Gut Microbiota and Inflammatory Markers in Infantile Colic: A Systematic Review, Meta-Analysis and Meta-Regression of Randomized Controlled Trials
Immaturity in digestive-tract motor function and altered intestinal microbiome may play roles in pathogenesis of infantile colic. We assessed the impact of probiotic therapy on crying duration day, in newborns experiencing colic attacks. The PubMed, Embase, Cinnahl, Web of Science databases, and a c...
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| Format: | Article |
| Language: | English |
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MDPI AG
2020-04-01
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| Series: | Journal of Clinical Medicine |
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| Online Access: | https://www.mdpi.com/2077-0383/9/4/999 |
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| author | Karolina Skonieczna-Żydecka Katarzyna Janda Mariusz Kaczmarczyk Wojciech Marlicz Igor Łoniewski Beata Łoniewska |
| author_facet | Karolina Skonieczna-Żydecka Katarzyna Janda Mariusz Kaczmarczyk Wojciech Marlicz Igor Łoniewski Beata Łoniewska |
| author_sort | Karolina Skonieczna-Żydecka |
| collection | DOAJ |
| description | Immaturity in digestive-tract motor function and altered intestinal microbiome may play roles in pathogenesis of infantile colic. We assessed the impact of probiotic therapy on crying duration day, in newborns experiencing colic attacks. The PubMed, Embase, Cinnahl, Web of Science databases, and a clinical trials registry (ClinicalTrials.gov) were searched from inception until 12/02/2020. Random-effects meta-analyses were used to derive standardized mean differences/differences in means and risk ratios. We included 16 studies, which involved 1319 newborns aged up to 6 months. <i>Lactobacillus reuteri</i> strain DSM17938 was administered predominantly (<i>n</i> = 10). Probiotic intervention reduced the duration of crying (standardized mean difference = −2.012, 95% confidence interval: −2.763 to −1.261, z = −5.25, <i>p</i> < 0.0001). The probability of at least a 50% reduction in crying duration was at least 1.98 times higher in the intervention group than in controls (Z = 4.80, <i>p</i> < 0.0001). The effects of the intervention were not significantly affected by the risk of bias assessment, percentage of breastfed infants, and duration of the study. In 11 studies, data concerning gut microbiota composition and function and/or immunological markers were given. Probiotics significantly shortened the crying duration, but a causal relationship between the modulatory effect of probiotics on microbiota and the immune system has not been confirmed. |
| first_indexed | 2024-03-10T20:42:45Z |
| format | Article |
| id | doaj.art-3dcb0433ab6b452ca94370a898b00dae |
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| issn | 2077-0383 |
| language | English |
| last_indexed | 2024-03-10T20:42:45Z |
| publishDate | 2020-04-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Journal of Clinical Medicine |
| spelling | doaj.art-3dcb0433ab6b452ca94370a898b00dae2023-11-19T20:31:51ZengMDPI AGJournal of Clinical Medicine2077-03832020-04-019499910.3390/jcm9040999The Effect of Probiotics on Symptoms, Gut Microbiota and Inflammatory Markers in Infantile Colic: A Systematic Review, Meta-Analysis and Meta-Regression of Randomized Controlled TrialsKarolina Skonieczna-Żydecka0Katarzyna Janda1Mariusz Kaczmarczyk2Wojciech Marlicz3Igor Łoniewski4Beata Łoniewska5Department of Human Nutrition and Metabolomics, Pomeranian Medical University in Szczecin, 71-460 Szczecin, PolandDepartment of Human Nutrition and Metabolomics, Pomeranian Medical University in Szczecin, 71-460 Szczecin, PolandDepartment of Clinical and Molecular Biochemistry, Pomeranian Medical University in Szczecin, 70-111 Szczecin, PolandDepartment of Gastroenterology, Pomeranian Medical University in Szczecin, 71-252 Szczecin, PolandDepartment of Human Nutrition and Metabolomics, Pomeranian Medical University in Szczecin, 71-460 Szczecin, PolandDepartment of Neonatal Diseases, Pomeranian Medical University in Szczecin, 70-111 Szczecin, PolandImmaturity in digestive-tract motor function and altered intestinal microbiome may play roles in pathogenesis of infantile colic. We assessed the impact of probiotic therapy on crying duration day, in newborns experiencing colic attacks. The PubMed, Embase, Cinnahl, Web of Science databases, and a clinical trials registry (ClinicalTrials.gov) were searched from inception until 12/02/2020. Random-effects meta-analyses were used to derive standardized mean differences/differences in means and risk ratios. We included 16 studies, which involved 1319 newborns aged up to 6 months. <i>Lactobacillus reuteri</i> strain DSM17938 was administered predominantly (<i>n</i> = 10). Probiotic intervention reduced the duration of crying (standardized mean difference = −2.012, 95% confidence interval: −2.763 to −1.261, z = −5.25, <i>p</i> < 0.0001). The probability of at least a 50% reduction in crying duration was at least 1.98 times higher in the intervention group than in controls (Z = 4.80, <i>p</i> < 0.0001). The effects of the intervention were not significantly affected by the risk of bias assessment, percentage of breastfed infants, and duration of the study. In 11 studies, data concerning gut microbiota composition and function and/or immunological markers were given. Probiotics significantly shortened the crying duration, but a causal relationship between the modulatory effect of probiotics on microbiota and the immune system has not been confirmed.https://www.mdpi.com/2077-0383/9/4/999infantile colicprobioticsgut microbiota |
| spellingShingle | Karolina Skonieczna-Żydecka Katarzyna Janda Mariusz Kaczmarczyk Wojciech Marlicz Igor Łoniewski Beata Łoniewska The Effect of Probiotics on Symptoms, Gut Microbiota and Inflammatory Markers in Infantile Colic: A Systematic Review, Meta-Analysis and Meta-Regression of Randomized Controlled Trials Journal of Clinical Medicine infantile colic probiotics gut microbiota |
| title | The Effect of Probiotics on Symptoms, Gut Microbiota and Inflammatory Markers in Infantile Colic: A Systematic Review, Meta-Analysis and Meta-Regression of Randomized Controlled Trials |
| title_full | The Effect of Probiotics on Symptoms, Gut Microbiota and Inflammatory Markers in Infantile Colic: A Systematic Review, Meta-Analysis and Meta-Regression of Randomized Controlled Trials |
| title_fullStr | The Effect of Probiotics on Symptoms, Gut Microbiota and Inflammatory Markers in Infantile Colic: A Systematic Review, Meta-Analysis and Meta-Regression of Randomized Controlled Trials |
| title_full_unstemmed | The Effect of Probiotics on Symptoms, Gut Microbiota and Inflammatory Markers in Infantile Colic: A Systematic Review, Meta-Analysis and Meta-Regression of Randomized Controlled Trials |
| title_short | The Effect of Probiotics on Symptoms, Gut Microbiota and Inflammatory Markers in Infantile Colic: A Systematic Review, Meta-Analysis and Meta-Regression of Randomized Controlled Trials |
| title_sort | effect of probiotics on symptoms gut microbiota and inflammatory markers in infantile colic a systematic review meta analysis and meta regression of randomized controlled trials |
| topic | infantile colic probiotics gut microbiota |
| url | https://www.mdpi.com/2077-0383/9/4/999 |
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