Dynamic Changes in Adiponectin and Resistin Drive Remission of Cardiometabolic Risk Biomarkers in Individuals with Obesity Following Bariatric Surgery
The remission of obesity-related diseases following bariatric surgery appears to result from the reorganization of metabolic and hormonal pathways involving adipokines. This study aimed to investigate the relationship between changes in body adiposity and serum adipokine levels, as well as the assoc...
| Main Authors: | , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2024-02-01
|
| Series: | Pharmaceuticals |
| Subjects: | |
| Online Access: | https://www.mdpi.com/1424-8247/17/2/215 |
| _version_ | 1797297259295014912 |
|---|---|
| author | Amanda Machado Fiorotti Amanda Cristina Araújo Gomes Amanda Motta Bortoli Beatriz Bobbio de Brito Karolini Zuqui Nunes Fabiano Kenji Haraguchi Andressa Bolsoni-Lopes |
| author_facet | Amanda Machado Fiorotti Amanda Cristina Araújo Gomes Amanda Motta Bortoli Beatriz Bobbio de Brito Karolini Zuqui Nunes Fabiano Kenji Haraguchi Andressa Bolsoni-Lopes |
| author_sort | Amanda Machado Fiorotti |
| collection | DOAJ |
| description | The remission of obesity-related diseases following bariatric surgery appears to result from the reorganization of metabolic and hormonal pathways involving adipokines. This study aimed to investigate the relationship between changes in body adiposity and serum adipokine levels, as well as the association between variations in adiponectin or resistin levels and cardiometabolic risk blood biomarkers before and after Roux-en-Y gastric bypass. A longitudinal and prospective study was conducted with bariatric surgery patients. Anthropometric, body composition and blood biochemical parameters were measured before and at 2 and 6 months post-surgery. The data were analyzed using ANOVA, Pearson or Spearman correlation, and simple linear regression with a significance level of <i>p</i> < 0.05. Among 36 mostly female patients aged 30 to 39 years, significant reductions in body weight (−26.8%), fat mass (−50%), waist circumference (−18%) and waist-to-height ratio (−22%) were observed post-surgery. Serum adiponectin levels increased (+107%), while resistin (−12.2%), TNF-α (−35%), and PAI-1 (−11.1%) decreased. Glucose, insulin, CRP, cholesterol, LDL-c, triglycerides, and vitamin D also decreased. Waist circumference variation showed a positive correlation with PAI-1 and TNF-α and a negative correlation with adiponectin. The total fat mass showed a positive correlation with PAI-1. Adiponectin variation correlated negatively with glucose, resistin, and CRP but positively with HDL-c. Resistin showed a positive correlation with insulin and CRP. In conclusion, 6 months post-bariatric surgery, reducing abdominal adiposity had a more significant impact on serum adipokine levels than total fat mass. Adiponectin increase and resistin decrease acted as endocrine mediators driving the remission of cardiometabolic risk biomarkers in individuals with obesity following Roux-en-Y gastric bypass. |
| first_indexed | 2024-03-07T22:17:44Z |
| format | Article |
| id | doaj.art-3dcb1ba4707345029f1f238c2038f519 |
| institution | Directory Open Access Journal |
| issn | 1424-8247 |
| language | English |
| last_indexed | 2024-03-07T22:17:44Z |
| publishDate | 2024-02-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Pharmaceuticals |
| spelling | doaj.art-3dcb1ba4707345029f1f238c2038f5192024-02-23T15:30:42ZengMDPI AGPharmaceuticals1424-82472024-02-0117221510.3390/ph17020215Dynamic Changes in Adiponectin and Resistin Drive Remission of Cardiometabolic Risk Biomarkers in Individuals with Obesity Following Bariatric SurgeryAmanda Machado Fiorotti0Amanda Cristina Araújo Gomes1Amanda Motta Bortoli2Beatriz Bobbio de Brito3Karolini Zuqui Nunes4Fabiano Kenji Haraguchi5Andressa Bolsoni-Lopes6Postgraduate Program in Nutrition and Health, Health Sciences Center, Federal University of Espirito Santo, Vitoria 29047-105, BrazilPostgraduate Program in Nutrition and Health, Health Sciences Center, Federal University of Espirito Santo, Vitoria 29047-105, BrazilPostgraduate Program in Nutrition and Health, Health Sciences Center, Federal University of Espirito Santo, Vitoria 29047-105, BrazilPostgraduate Program in Nutrition and Health, Health Sciences Center, Federal University of Espirito Santo, Vitoria 29047-105, BrazilPostgraduate Program in Nutrition and Health, Health Sciences Center, Federal University of Espirito Santo, Vitoria 29047-105, BrazilPostgraduate Program in Nutrition and Health, Health Sciences Center, Federal University of Espirito Santo, Vitoria 29047-105, BrazilPostgraduate Program in Nutrition and Health, Health Sciences Center, Federal University of Espirito Santo, Vitoria 29047-105, BrazilThe remission of obesity-related diseases following bariatric surgery appears to result from the reorganization of metabolic and hormonal pathways involving adipokines. This study aimed to investigate the relationship between changes in body adiposity and serum adipokine levels, as well as the association between variations in adiponectin or resistin levels and cardiometabolic risk blood biomarkers before and after Roux-en-Y gastric bypass. A longitudinal and prospective study was conducted with bariatric surgery patients. Anthropometric, body composition and blood biochemical parameters were measured before and at 2 and 6 months post-surgery. The data were analyzed using ANOVA, Pearson or Spearman correlation, and simple linear regression with a significance level of <i>p</i> < 0.05. Among 36 mostly female patients aged 30 to 39 years, significant reductions in body weight (−26.8%), fat mass (−50%), waist circumference (−18%) and waist-to-height ratio (−22%) were observed post-surgery. Serum adiponectin levels increased (+107%), while resistin (−12.2%), TNF-α (−35%), and PAI-1 (−11.1%) decreased. Glucose, insulin, CRP, cholesterol, LDL-c, triglycerides, and vitamin D also decreased. Waist circumference variation showed a positive correlation with PAI-1 and TNF-α and a negative correlation with adiponectin. The total fat mass showed a positive correlation with PAI-1. Adiponectin variation correlated negatively with glucose, resistin, and CRP but positively with HDL-c. Resistin showed a positive correlation with insulin and CRP. In conclusion, 6 months post-bariatric surgery, reducing abdominal adiposity had a more significant impact on serum adipokine levels than total fat mass. Adiponectin increase and resistin decrease acted as endocrine mediators driving the remission of cardiometabolic risk biomarkers in individuals with obesity following Roux-en-Y gastric bypass.https://www.mdpi.com/1424-8247/17/2/215bariatric surgeryobesity managementabdominal adipositycardiometabolic risk factorsadiponectinresistin |
| spellingShingle | Amanda Machado Fiorotti Amanda Cristina Araújo Gomes Amanda Motta Bortoli Beatriz Bobbio de Brito Karolini Zuqui Nunes Fabiano Kenji Haraguchi Andressa Bolsoni-Lopes Dynamic Changes in Adiponectin and Resistin Drive Remission of Cardiometabolic Risk Biomarkers in Individuals with Obesity Following Bariatric Surgery Pharmaceuticals bariatric surgery obesity management abdominal adiposity cardiometabolic risk factors adiponectin resistin |
| title | Dynamic Changes in Adiponectin and Resistin Drive Remission of Cardiometabolic Risk Biomarkers in Individuals with Obesity Following Bariatric Surgery |
| title_full | Dynamic Changes in Adiponectin and Resistin Drive Remission of Cardiometabolic Risk Biomarkers in Individuals with Obesity Following Bariatric Surgery |
| title_fullStr | Dynamic Changes in Adiponectin and Resistin Drive Remission of Cardiometabolic Risk Biomarkers in Individuals with Obesity Following Bariatric Surgery |
| title_full_unstemmed | Dynamic Changes in Adiponectin and Resistin Drive Remission of Cardiometabolic Risk Biomarkers in Individuals with Obesity Following Bariatric Surgery |
| title_short | Dynamic Changes in Adiponectin and Resistin Drive Remission of Cardiometabolic Risk Biomarkers in Individuals with Obesity Following Bariatric Surgery |
| title_sort | dynamic changes in adiponectin and resistin drive remission of cardiometabolic risk biomarkers in individuals with obesity following bariatric surgery |
| topic | bariatric surgery obesity management abdominal adiposity cardiometabolic risk factors adiponectin resistin |
| url | https://www.mdpi.com/1424-8247/17/2/215 |
| work_keys_str_mv | AT amandamachadofiorotti dynamicchangesinadiponectinandresistindriveremissionofcardiometabolicriskbiomarkersinindividualswithobesityfollowingbariatricsurgery AT amandacristinaaraujogomes dynamicchangesinadiponectinandresistindriveremissionofcardiometabolicriskbiomarkersinindividualswithobesityfollowingbariatricsurgery AT amandamottabortoli dynamicchangesinadiponectinandresistindriveremissionofcardiometabolicriskbiomarkersinindividualswithobesityfollowingbariatricsurgery AT beatrizbobbiodebrito dynamicchangesinadiponectinandresistindriveremissionofcardiometabolicriskbiomarkersinindividualswithobesityfollowingbariatricsurgery AT karolinizuquinunes dynamicchangesinadiponectinandresistindriveremissionofcardiometabolicriskbiomarkersinindividualswithobesityfollowingbariatricsurgery AT fabianokenjiharaguchi dynamicchangesinadiponectinandresistindriveremissionofcardiometabolicriskbiomarkersinindividualswithobesityfollowingbariatricsurgery AT andressabolsonilopes dynamicchangesinadiponectinandresistindriveremissionofcardiometabolicriskbiomarkersinindividualswithobesityfollowingbariatricsurgery |